101 related articles for article (PubMed ID: 9635875)
1. The metabolic activation of tamoxifen and alpha-hydroxytamoxifen to DNA-binding species in rat hepatocytes proceeds via sulphation.
Davis W; Venitt S; Phillips DH
Carcinogenesis; 1998 May; 19(5):861-6. PubMed ID: 9635875
[TBL] [Abstract][Full Text] [Related]
2. Activation of tamoxifen and its metabolite alpha-hydroxytamoxifen to DNA-binding products: comparisons between human, rat and mouse hepatocytes.
Phillips DH; Carmichael PL; Hewer A; Cole KJ; Hardcastle IR; Poon GK; Keogh A; Strain AJ
Carcinogenesis; 1996 Jan; 17(1):89-94. PubMed ID: 8565142
[TBL] [Abstract][Full Text] [Related]
3. N-demethylation accompanies alpha-hydroxylation in the metabolic activation of tamoxifen in rat liver cells.
Phillips DH; Hewer A; Horton MN; Cole KJ; Carmichael PL; Davis W; Osborne MR
Carcinogenesis; 1999 Oct; 20(10):2003-9. PubMed ID: 10506117
[TBL] [Abstract][Full Text] [Related]
4. alpha-Hydroxytamoxifen, a metabolite of tamoxifen with exceptionally high DNA-binding activity in rat hepatocytes.
Phillips DH; Carmichael PL; Hewer A; Cole KJ; Poon GK
Cancer Res; 1994 Nov; 54(21):5518-22. PubMed ID: 7923188
[TBL] [Abstract][Full Text] [Related]
5. 4-Hydroxytamoxifen gives DNA adducts by chemical activation, but not in rat liver cells.
Osborne MR; Davis W; Hewer AJ; Hardcastle IR; Phillips DH
Chem Res Toxicol; 1999 Feb; 12(2):151-8. PubMed ID: 10027792
[TBL] [Abstract][Full Text] [Related]
6. Sex differences in the activation of tamoxifen to DNA binding species in rat liver in vivo and in rat hepatocytes in vitro: role of sulfotransferase induction.
Davis W; Hewer A; Rajkowski KM; Meinl W; Glatt H; Phillips DH
Cancer Res; 2000 Jun; 60(11):2887-91. PubMed ID: 10850433
[TBL] [Abstract][Full Text] [Related]
7. Major inter-species differences in the rates of O-sulphonation and O-glucuronylation of alpha-hydroxytamoxifen in vitro: a metabolic disparity protecting human liver from the formation of tamoxifen-DNA adducts.
Boocock DJ; Maggs JL; Brown K; White IN; Park BK
Carcinogenesis; 2000 Oct; 21(10):1851-8. PubMed ID: 11023543
[TBL] [Abstract][Full Text] [Related]
8. Organ specificity of DNA adduct formation by tamoxifen and alpha-hydroxytamoxifen in the rat: implications for understanding the mechanism(s) of tamoxifen carcinogenicity and for human risk assessment.
Phillips DH; Hewer A; Osborne MR; Cole KJ; Churchill C; Arlt VM
Mutagenesis; 2005 Jul; 20(4):297-303. PubMed ID: 15928012
[TBL] [Abstract][Full Text] [Related]
9. Determination of DNA damage in F344 rats induced by geometric isomers of tamoxifen and analogues.
Brown K; Brown JE; Martin EA; Smith LL; White IN
Chem Res Toxicol; 1998 May; 11(5):527-34. PubMed ID: 9585484
[TBL] [Abstract][Full Text] [Related]
10. Alpha-hydroxytamoxifen, a genotoxic metabolite of tamoxifen in the rat: identification and quantification in vivo and in vitro.
Boocock DJ; Maggs JL; White IN; Park BK
Carcinogenesis; 1999 Jan; 20(1):153-60. PubMed ID: 9934863
[TBL] [Abstract][Full Text] [Related]
11. DNA adduct formation and mutant induction in Sprague-Dawley rats treated with tamoxifen and its derivatives.
Gamboa da Costa G; McDaniel-Hamilton LP; Heflich RH; Marques MM; Beland FA
Carcinogenesis; 2001 Aug; 22(8):1307-15. PubMed ID: 11470763
[TBL] [Abstract][Full Text] [Related]
12. Tamoxifen: evidence by 32P-postlabeling and use of metabolic inhibitors for two distinct pathways leading to mouse hepatic DNA adduct formation and identification of 4-hydroxytamoxifen as a proximate metabolite.
Randerath K; Moorthy B; Mabon N; Sriram P
Carcinogenesis; 1994 Oct; 15(10):2087-94. PubMed ID: 7955037
[TBL] [Abstract][Full Text] [Related]
13. Tamoxifen metabolic activation: comparison of DNA adducts formed by microsomal and chemical activation of tamoxifen and 4-hydroxytamoxifen with DNA adducts formed in vivo.
Moorthy B; Sriram P; Pathak DN; Bodell WJ; Randerath K
Cancer Res; 1996 Jan; 56(1):53-7. PubMed ID: 8548775
[TBL] [Abstract][Full Text] [Related]
14. Comparison of the DNA adducts formed by tamoxifen and 4-hydroxytamoxifen in vivo.
Beland FA; McDaniel LP; Marques MM
Carcinogenesis; 1999 Mar; 20(3):471-7. PubMed ID: 10190564
[TBL] [Abstract][Full Text] [Related]
15. Evaluation of tamoxifen and alpha-hydroxytamoxifen 32P-post-labelled DNA adducts by the development of a novel automated on-line solid-phase extraction HPLC method.
Martin EA; Heydon RT; Brown K; Brown JE; Lim CK; White IN; Smith LL
Carcinogenesis; 1998 Jun; 19(6):1061-9. PubMed ID: 9667745
[TBL] [Abstract][Full Text] [Related]
16. Idoxifene derivatives are less reactive to DNA than tamoxifen derivatives, both chemically and in human and rat liver cells.
Osborne MR; Hewer A; Davis W; Strain AJ; Keogh A; Hardcastle IR; Phillips DH
Carcinogenesis; 1999 Feb; 20(2):293-7. PubMed ID: 10069467
[TBL] [Abstract][Full Text] [Related]
17. Reduced genotoxicity of [D5-ethyl]-tamoxifen implicates alpha-hydroxylation of the ethyl group as a major pathway of tamoxifen activation to a liver carcinogen.
Phillips DH; Potter GA; Horton MN; Hewer A; Crofton-Sleigh C; Jarman M; Venitt S
Carcinogenesis; 1994 Aug; 15(8):1487-92. PubMed ID: 8055624
[TBL] [Abstract][Full Text] [Related]
18. Rat, but not human, sulfotransferase activates a tamoxifen metabolite to produce DNA adducts and gene mutations in bacteria and mammalian cells in culture.
Glatt H; Davis W; Meinl W; Hermersdörfer H; Venitt S; Phillips DH
Carcinogenesis; 1998 Oct; 19(10):1709-13. PubMed ID: 9806149
[TBL] [Abstract][Full Text] [Related]
19. Short-term dosing of alpha-hydroxytamoxifen results in DNA damage but does not lead to liver tumours in female Wistar/Han rats.
White IN; Carthew P; Davies R; Styles J; Brown K; Brown JE; Smith LL; Martin EA
Carcinogenesis; 2001 Apr; 22(4):553-7. PubMed ID: 11285188
[TBL] [Abstract][Full Text] [Related]
20. Formation of tamoxifen-DNA adducts via O-sulfonation, not O-acetylation, of alpha-hydroxytamoxifen in rat and human livers.
Kim SY; Laxmi YR; Suzuki N; Ogura K; Watabe T; Duffel MW; Shibutani S
Drug Metab Dispos; 2005 Nov; 33(11):1673-8. PubMed ID: 16099924
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
