217 related articles for article (PubMed ID: 9651152)
1. Inhibition of human neutrophil elastase. 4. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of P2-modified, orally active peptidyl pentafluoroethyl ketones.
Cregge RJ; Durham SL; Farr RA; Gallion SL; Hare CM; Hoffman RV; Janusz MJ; Kim HO; Koehl JR; Mehdi S; Metz WA; Peet NP; Pelton JT; Schreuder HA; Sunder S; Tardif C
J Med Chem; 1998 Jul; 41(14):2461-80. PubMed ID: 9651152
[TBL] [Abstract][Full Text] [Related]
2. Nonpeptidic inhibitors of human leukocyte elastase. 3. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of orally active 3-amino-6-phenylpyridin-2-one trifluoromethyl ketones.
Bernstein PR; Andisik D; Bradley PK; Bryant CB; Ceccarelli C; Damewood JR; Earley R; Edwards PD; Feeney S; Gomes BC
J Med Chem; 1994 Sep; 37(20):3313-26. PubMed ID: 7932559
[TBL] [Abstract][Full Text] [Related]
3. The crystal structure of the complex of non-peptidic inhibitor of human neutrophil elastase ONO-6818 and porcine pancreatic elastase.
Odagaki Y; Ohmoto K; Matsuoka S; Hamanaka N; Nakai H; Toda M; Katsuya Y
Bioorg Med Chem; 2001 Mar; 9(3):647-51. PubMed ID: 11310599
[TBL] [Abstract][Full Text] [Related]
4. Inhibition of human neutrophil elastase with peptidyl electrophilic ketones. 2. Orally active PG-Val-Pro-Val pentafluoroethyl ketones.
Angelastro MR; Baugh LE; Bey P; Burkhart JP; Chen TM; Durham SL; Hare CM; Huber EW; Janusz MJ; Koehl JR
J Med Chem; 1994 Dec; 37(26):4538-53. PubMed ID: 7799404
[TBL] [Abstract][Full Text] [Related]
5. Crystal structure of an elastase-specific inhibitor elafin complexed with porcine pancreatic elastase determined at 1.9 A resolution.
Tsunemi M; Matsuura Y; Sakakibara S; Katsube Y
Biochemistry; 1996 Sep; 35(36):11570-6. PubMed ID: 8794736
[TBL] [Abstract][Full Text] [Related]
6. Inhibition of human leukocyte elastase (HLE) by N-substituted peptidyl trifluoromethyl ketones.
Skiles JW; Fuchs V; Miao C; Sorcek R; Grozinger KG; Mauldin SC; Vitous J; Mui PW; Jacober S; Chow G
J Med Chem; 1992 Feb; 35(4):641-62. PubMed ID: 1542092
[TBL] [Abstract][Full Text] [Related]
7. Pharmacology of N-[4-(4-morpholinylcarbonyl)benzoyl]-L-valyl-N- [3,3,4,4,4-pentafluoro-1-(1-methylethyl)-2-oxobutyl]-L-prolinamide (MDL 101,146): a potent orally active inhibitor of human neutrophil elastase.
Durham SL; Hare CM; Angelastro MR; Burkhart JP; Koehl JR; Marquart AL; Mehdi S; Peet NP; Janusz MJ
J Pharmacol Exp Ther; 1994 Jul; 270(1):185-91. PubMed ID: 8035315
[TBL] [Abstract][Full Text] [Related]
8. Nonpeptidic inhibitors of human neutrophil elastase. 7. Design, synthesis, and in vitro activity of a series of pyridopyrimidine trifluoromethyl ketones.
Edwards PD; Andisik DW; Strimpler AM; Gomes B; Tuthill PA
J Med Chem; 1996 Mar; 39(5):1112-24. PubMed ID: 8676347
[TBL] [Abstract][Full Text] [Related]
9. Nonpeptidic inhibitors of human leukocyte elastase. 5. Design, synthesis, and X-ray crystallography of a series of orally active 5-aminopyrimidin-6-one-containing trifluoromethyl ketones.
Veale CA; Bernstein PR; Bryant C; Ceccarelli C; Damewood JR; Earley R; Feeney SW; Gomes B; Kosmider BJ; Steelman GB
J Med Chem; 1995 Jan; 38(1):98-108. PubMed ID: 7837246
[TBL] [Abstract][Full Text] [Related]
10. Non-peptidic inhibitors of human leukocyte elastase. 4. Design, synthesis, and in vitro and in vivo activity of a series of beta-carbolinone-containing trifluoromethyl ketones.
Veale CA; Damewood JR; Steelman GB; Bryant C; Gomes B; Williams J
J Med Chem; 1995 Jan; 38(1):86-97. PubMed ID: 7837244
[TBL] [Abstract][Full Text] [Related]
11. N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases.
Santana AB; Lucas SD; Gonçalves LM; Correia HF; Cardote TA; Guedes RC; Iley J; Moreira R
Bioorg Med Chem Lett; 2012 Jun; 22(12):3993-7. PubMed ID: 22595175
[TBL] [Abstract][Full Text] [Related]
12. Orally active trifluoromethyl ketone inhibitors of human leukocyte elastase.
Veale CA; Bernstein PR; Bohnert CM; Brown FJ; Bryant C; Damewood JR; Earley R; Feeney SW; Edwards PD; Gomes B; Hulsizer JM; Kosmider BJ; Krell RD; Moore G; Salcedo TW; Shaw A; Silberstein DS; Steelman GB; Stein M; Strimpler A; Thomas RM; Vacek EP; Williams JC; Wolanin DJ; Woolson S
J Med Chem; 1997 Sep; 40(20):3173-81. PubMed ID: 9379436
[TBL] [Abstract][Full Text] [Related]
13. Synthesis of peptidyl fluoromethyl ketones and peptidyl alpha-keto esters as inhibitors of porcine pancreatic elastase, human neutrophil elastase, and rat and human neutrophil cathepsin G.
Peet NP; Burkhart JP; Angelastro MR; Giroux EL; Mehdi S; Bey P; Kolb M; Neises B; Schirlin D
J Med Chem; 1990 Jan; 33(1):394-407. PubMed ID: 2296031
[TBL] [Abstract][Full Text] [Related]
14. Non-peptidic inhibitors of human leukocyte elastase. 1. The design and synthesis of pyridone-containing inhibitors.
Warner P; Green RC; Gomes B; Strimpler AM
J Med Chem; 1994 Sep; 37(19):3090-9. PubMed ID: 7932532
[TBL] [Abstract][Full Text] [Related]
15. Pharmacological evaluation of selected, orally active, peptidyl inhibitors of human neutrophil elastase.
Janusz MJ; Durham SL; Hare CM; Geary JL; Mandagere AK; Poole JC; Thompson TN; Xu D; Anagelastro MR; Burkhart JP
J Pharmacol Exp Ther; 1995 Dec; 275(3):1233-8. PubMed ID: 8531086
[TBL] [Abstract][Full Text] [Related]
16. Novel potent hepatitis C virus NS3 serine protease inhibitors derived from proline-based macrocycles.
Chen KX; Njoroge FG; Arasappan A; Venkatraman S; Vibulbhan B; Yang W; Parekh TN; Pichardo J; Prongay A; Cheng KC; Butkiewicz N; Yao N; Madison V; Girijavallabhan V
J Med Chem; 2006 Feb; 49(3):995-1005. PubMed ID: 16451065
[TBL] [Abstract][Full Text] [Related]
17. Highly potent and selective peptide-based inhibitors of the hepatitis C virus serine protease: towards smaller inhibitors.
Llinàs-Brunet M; Bailey M; Fazal G; Ghiro E; Gorys V; Goulet S; Halmos T; Maurice R; Poirier M; Poupart MA; Rancourt J; Thibeault D; Wernic D; Lamarre D
Bioorg Med Chem Lett; 2000 Oct; 10(20):2267-70. PubMed ID: 11055335
[TBL] [Abstract][Full Text] [Related]
18. Stereoselective synthesis of peptidyl trifluoromethyl alcohols and ketones: inhibitory potency against human leucocyte elastase, cathepsin G, porcine pancreatic elastase and HIV-1 protease.
Amour A; Reboud-Ravaux M; de Rosny E; Abouabdellah A; Bégue JP; Bonnet-Delpon D; Le Gall M
J Pharm Pharmacol; 1998 Jun; 50(6):593-600. PubMed ID: 9680068
[TBL] [Abstract][Full Text] [Related]
19. Biochemical and pharmacological characterization of ICI 186,756: a novel, potent, and selective inhibitor of human neutrophil elastase.
Williams JC; Stein RL; Strimpler AM; Reaves B; Krell RD
Exp Lung Res; 1991; 17(4):725-41. PubMed ID: 1935833
[TBL] [Abstract][Full Text] [Related]
20. Proline-based macrocyclic inhibitors of the hepatitis C virus: stereoselective synthesis and biological activity.
Chen KX; Njoroge FG; Vibulbhan B; Prongay A; Pichardo J; Madison V; Buevich A; Chan TM
Angew Chem Int Ed Engl; 2005 Nov; 44(43):7024-8. PubMed ID: 16211639
[No Abstract] [Full Text] [Related]
[Next] [New Search]
