190 related articles for article (PubMed ID: 9651333)
1. Characterization of aggrecan retained and lost from the extracellular matrix of articular cartilage. Involvement of carboxyl-terminal processing in the catabolism of aggrecan.
Ilic MZ; Robinson HC; Handley CJ
J Biol Chem; 1998 Jul; 273(28):17451-8. PubMed ID: 9651333
[TBL] [Abstract][Full Text] [Related]
2. Cathepsin D cleaves aggrecan at unique sites within the interglobular domain and chondroitin sulfate attachment regions that are also cleaved when cartilage is maintained at acid pH.
Handley CJ; Mok MT; Ilic MZ; Adcocks C; Buttle DJ; Robinson HC
Matrix Biol; 2001 Dec; 20(8):543-53. PubMed ID: 11731271
[TBL] [Abstract][Full Text] [Related]
3. Cell-mediated catabolism of aggrecan. Evidence that cleavage at the "aggrecanase" site (Glu373-Ala374) is a primary event in proteolysis of the interglobular domain.
Lark MW; Gordy JT; Weidner JR; Ayala J; Kimura JH; Williams HR; Mumford RA; Flannery CR; Carlson SS; Iwata M
J Biol Chem; 1995 Feb; 270(6):2550-6. PubMed ID: 7852317
[TBL] [Abstract][Full Text] [Related]
4. Mechanism of catabolism of aggrecan by articular cartilage.
Ilic MZ; Handley CJ; Robinson HC; Mok MT
Arch Biochem Biophys; 1992 Apr; 294(1):115-22. PubMed ID: 1550337
[TBL] [Abstract][Full Text] [Related]
5. Catabolism of aggrecan by explant cultures of human articular cartilage in the presence of retinoic acid.
Ilic MZ; Mok MT; Williamson OD; Campbell MA; Hughes CE; Handley CJ
Arch Biochem Biophys; 1995 Sep; 322(1):22-30. PubMed ID: 7574678
[TBL] [Abstract][Full Text] [Related]
6. The interglobular domain of cartilage aggrecan is cleaved by hemorrhagic metalloproteinase HT-d (atrolysin C) at the matrix metalloproteinase and aggrecanase sites.
Tortorella MD; Pratta MA; Fox JW; Arner EC
J Biol Chem; 1998 Mar; 273(10):5846-50. PubMed ID: 9488721
[TBL] [Abstract][Full Text] [Related]
7. Catabolism of aggrecan in cartilage explants. Identification of a major cleavage site within the interglobular domain.
Sandy JD; Neame PJ; Boynton RE; Flannery CR
J Biol Chem; 1991 May; 266(14):8683-5. PubMed ID: 2026585
[TBL] [Abstract][Full Text] [Related]
8. Analysis of the catabolism of aggrecan in cartilage explants by quantitation of peptides from the three globular domains.
Sandy JD; Boynton RE; Flannery CR
J Biol Chem; 1991 May; 266(13):8198-205. PubMed ID: 2022637
[TBL] [Abstract][Full Text] [Related]
9. Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.
Little CB; Flannery CR; Hughes CE; Mort JS; Roughley PJ; Dent C; Caterson B
Biochem J; 1999 Nov; 344 Pt 1(Pt 1):61-8. PubMed ID: 10548534
[TBL] [Abstract][Full Text] [Related]
10. The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain.
Sandy JD; Flannery CR; Neame PJ; Lohmander LS
J Clin Invest; 1992 May; 89(5):1512-6. PubMed ID: 1569188
[TBL] [Abstract][Full Text] [Related]
11. Highly sulfated glycosaminoglycans inhibit aggrecanase degradation of aggrecan by bovine articular cartilage explant cultures.
Munteanu SE; Ilic MZ; Handley CJ
Matrix Biol; 2002 Aug; 21(5):429-40. PubMed ID: 12225808
[TBL] [Abstract][Full Text] [Related]
12. Mature bovine articular cartilage contains abundant aggrecan that is C-terminally truncated at Ala719-Ala720, a site which is readily cleaved by m-calpain.
Oshita H; Sandy JD; Suzuki K; Akaike A; Bai Y; Sasaki T; Shimizu K
Biochem J; 2004 Aug; 382(Pt 1):253-9. PubMed ID: 15175011
[TBL] [Abstract][Full Text] [Related]
13. Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation.
Little CB; Hughes CE; Curtis CL; Janusz MJ; Bohne R; Wang-Weigand S; Taiwo YO; Mitchell PG; Otterness IG; Flannery CR; Caterson B
Matrix Biol; 2002 Apr; 21(3):271-88. PubMed ID: 12009333
[TBL] [Abstract][Full Text] [Related]
14. Cytokine-induced cartilage proteoglycan degradation is mediated by aggrecanase.
Arner EC; Hughes CE; Decicco CP; Caterson B; Tortorella MD
Osteoarthritis Cartilage; 1998 May; 6(3):214-28. PubMed ID: 9682788
[TBL] [Abstract][Full Text] [Related]
15. Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (ADAMTS) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for C-terminal processing in vivo.
Sandy JD; Verscharen C
Biochem J; 2001 Sep; 358(Pt 3):615-26. PubMed ID: 11535123
[TBL] [Abstract][Full Text] [Related]
16. The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis.
Lohmander LS; Neame PJ; Sandy JD
Arthritis Rheum; 1993 Sep; 36(9):1214-22. PubMed ID: 8216415
[TBL] [Abstract][Full Text] [Related]
17. Generation and novel distribution of matrix metalloproteinase-derived aggrecan fragments in porcine cartilage explants.
Fosang AJ; Last K; Stanton H; Weeks DB; Campbell IK; Hardingham TE; Hembry RM
J Biol Chem; 2000 Oct; 275(42):33027-37. PubMed ID: 10882746
[TBL] [Abstract][Full Text] [Related]
18. Characterisation of proteoglycans and their catabolic products in tendon and explant cultures of tendon.
Samiric T; Ilic MZ; Handley CJ
Matrix Biol; 2004 May; 23(2):127-40. PubMed ID: 15246111
[TBL] [Abstract][Full Text] [Related]
19. Aggrecan in bovine tendon.
Vogel KG; Sandy JD; Pogány G; Robbins JR
Matrix Biol; 1994 Mar; 14(2):171-9. PubMed ID: 7520336
[TBL] [Abstract][Full Text] [Related]
20. Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan substrate rAgg1mut at the 'aggrecanase' and the MMP sites. Characterization of MT1-MMP catabolic activities on the interglobular domain of aggrecan.
Büttner FH; Hughes CE; Margerie D; Lichte A; Tschesche H; Caterson B; Bartnik E
Biochem J; 1998 Jul; 333 ( Pt 1)(Pt 1):159-65. PubMed ID: 9639575
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
