BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

286 related articles for article (PubMed ID: 9655946)

  • 1. Biosynthesis of 2-aceto-2-hydroxy acids: acetolactate synthases and acetohydroxyacid synthases.
    Chipman D; Barak Z; Schloss JV
    Biochim Biophys Acta; 1998 Jun; 1385(2):401-19. PubMed ID: 9655946
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Many of the functional differences between acetohydroxyacid synthase (AHAS) isozyme I and other AHASs are a result of the rapid formation and breakdown of the covalent acetolactate-thiamin diphosphate adduct in AHAS I.
    Belenky I; Steinmetz A; Vyazmensky M; Barak Z; Tittmann K; Chipman DM
    FEBS J; 2012 Jun; 279(11):1967-79. PubMed ID: 22443469
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Binding and activation of thiamin diphosphate in acetohydroxyacid synthase.
    Bar-Ilan A; Balan V; Tittmann K; Golbik R; Vyazmensky M; Hübner G; Barak Z; Chipman DM
    Biochemistry; 2001 Oct; 40(39):11946-54. PubMed ID: 11570896
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The crystal structures of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate.
    Pang SS; Duggleby RG; Schowen RL; Guddat LW
    J Biol Chem; 2004 Jan; 279(3):2242-53. PubMed ID: 14557277
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Significant catalytic roles for Glu47 and Gln 110 in all four of the C-C bond-making and -breaking steps of the reactions of acetohydroxyacid synthase II.
    Vyazmensky M; Steinmetz A; Meyer D; Golbik R; Barak Z; Tittmann K; Chipman DM
    Biochemistry; 2011 Apr; 50(15):3250-60. PubMed ID: 21370850
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Valine 375 and phenylalanine 109 confer affinity and specificity for pyruvate as donor substrate in acetohydroxy acid synthase isozyme II from Escherichia coli.
    Steinmetz A; Vyazmensky M; Meyer D; Barak ZE; Golbik R; Chipman DM; Tittmann K
    Biochemistry; 2010 Jun; 49(25):5188-99. PubMed ID: 20504042
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Acetohydroxyacid synthase: a target for antimicrobial drug discovery.
    Pue N; Guddat LW
    Curr Pharm Des; 2014; 20(5):740-53. PubMed ID: 23688082
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Homology modeling of the structure of bacterial acetohydroxy acid synthase and examination of the active site by site-directed mutagenesis.
    Ibdah M; Bar-Ilan A; Livnah O; Schloss JV; Barak Z; Chipman DM
    Biochemistry; 1996 Dec; 35(50):16282-91. PubMed ID: 8973202
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Acetohydroxyacid synthases: evolution, structure, and function.
    Liu Y; Li Y; Wang X
    Appl Microbiol Biotechnol; 2016 Oct; 100(20):8633-49. PubMed ID: 27576495
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Acetohydroxyacid synthase isozyme I from Escherichia coli has unique catalytic and regulatory properties.
    Vinogradov V; Vyazmensky M; Engel S; Belenky I; Kaplun A; Kryukov O; Barak Z; Chipman DM
    Biochim Biophys Acta; 2006 Mar; 1760(3):356-63. PubMed ID: 16326011
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Electron transfer in acetohydroxy acid synthase as a side reaction of catalysis. Implications for the reactivity and partitioning of the carbanion/enamine form of (alpha-hydroxyethyl)thiamin diphosphate in a "nonredox" flavoenzyme.
    Tittmann K; Schröder K; Golbik R; McCourt J; Kaplun A; Duggleby RG; Barak Z; Chipman DM; Hübner G
    Biochemistry; 2004 Jul; 43(27):8652-61. PubMed ID: 15236573
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mutagenesis of Escherichia coli acetohydroxyacid synthase isoenzyme II and characterization of three herbicide-insensitive forms.
    Hill CM; Duggleby RG
    Biochem J; 1998 Nov; 335 ( Pt 3)(Pt 3):653-61. PubMed ID: 9794808
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Role of a highly conserved proline-126 in ThDP binding of Mycobacterium tuberculosis acetohydroxyacid synthase.
    Baig IA; Gedi V; Lee SC; Koh SH; Yoon MY
    Enzyme Microb Technol; 2013 Sep; 53(4):243-9. PubMed ID: 23931689
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Crystal structure of yeast acetohydroxyacid synthase: a target for herbicidal inhibitors.
    Pang SS; Duggleby RG; Guddat LW
    J Mol Biol; 2002 Mar; 317(2):249-62. PubMed ID: 11902841
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Allosteric regulation in Acetohydroxyacid Synthases (AHASs)--different structures and kinetic behavior in isozymes in the same organisms.
    Barak Z; Chipman DM
    Arch Biochem Biophys; 2012 Mar; 519(2):167-74. PubMed ID: 22198286
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structure of the regulatory subunit of acetohydroxyacid synthase isozyme III from Escherichia coli.
    Kaplun A; Vyazmensky M; Zherdev Y; Belenky I; Slutzker A; Mendel S; Barak Z; Chipman DM; Shaanan B
    J Mol Biol; 2006 Mar; 357(3):951-63. PubMed ID: 16458324
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mechanisms of bacterial acetohydroxyacid synthase (AHAS) and specific inhibitors of Mycobacterium tuberculosis AHAS as potential drug candidates against tuberculosis.
    Gokhale K; Tilak B
    Curr Drug Targets; 2015; 16(7):689-99. PubMed ID: 25882218
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Characterization of acetohydroxyacid synthase I from Escherichia coli K-12 and identification of its inhibitors.
    Pham NC; Moon JY; Cho JH; Lee SJ; Park JS; Kim DE; Park Y; Yoon MY
    Biosci Biotechnol Biochem; 2010; 74(11):2281-6. PubMed ID: 21071847
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Acetohydroxyacid synthase: a proposed structure for regulatory subunits supported by evidence from mutagenesis.
    Mendel S; Elkayam T; Sella C; Vinogradov V; Vyazmensky M; Chipman DM; Barak Z
    J Mol Biol; 2001 Mar; 307(1):465-77. PubMed ID: 11243831
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Role of a conserved arginine in the mechanism of acetohydroxyacid synthase: catalysis of condensation with a specific ketoacid substrate.
    Engel S; Vyazmensky M; Vinogradov M; Berkovich D; Bar-Ilan A; Qimron U; Rosiansky Y; Barak Z; Chipman DM
    J Biol Chem; 2004 Jun; 279(23):24803-12. PubMed ID: 15044456
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.