BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

451 related articles for article (PubMed ID: 9657685)

  • 1. Effects of changes in three catalytic residues on the relative stabilities of some of the intermediates and transition states in the citrate synthase reaction.
    Kurz LC; Nakra T; Stein R; Plungkhen W; Riley M; Hsu F; Drysdale GR
    Biochemistry; 1998 Jul; 37(27):9724-37. PubMed ID: 9657685
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Ability of single-site mutants of citrate synthase to catalyze proton transfer from the methyl group of dethiaacetyl-coenzyme A, a non-thioester substrate analog.
    Kurz LC; Roble JH; Nakra T; Drysdale GR; Buzan JM; Schwartz B; Drueckhammer DG
    Biochemistry; 1997 Apr; 36(13):3981-90. PubMed ID: 9092828
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Catalytic strategy of citrate synthase: subunit interactions revealed as a consequence of a single amino acid change in the oxaloacetate binding site.
    Kurz LC; Shah S; Frieden C; Nakra T; Stein RE; Drysdale GR; Evans CT; Srere PA
    Biochemistry; 1995 Oct; 34(41):13278-88. PubMed ID: 7577912
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Substrate polarization in enzyme catalysis: QM/MM analysis of the effect of oxaloacetate polarization on acetyl-CoA enolization in citrate synthase.
    van der Kamp MW; Perruccio F; Mulholland AJ
    Proteins; 2007 Nov; 69(3):521-35. PubMed ID: 17623847
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Active site mutants of pig citrate synthase: effects of mutations on the enzyme catalytic and structural properties.
    Evans CT; Kurz LC; Remington SJ; Srere PA
    Biochemistry; 1996 Aug; 35(33):10661-72. PubMed ID: 8718855
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Kinetics and mechanism of the citrate synthase from the thermophilic archaeon Thermoplasma acidophilum.
    Kurz LC; Drysdale G; Riley M; Tomar MA; Chen J; Russell RJ; Danson MJ
    Biochemistry; 2000 Mar; 39(9):2283-96. PubMed ID: 10694395
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Solid state NMR studies of hydrogen bonding in a citrate synthase inhibitor complex.
    Gu Z; Drueckhammer DG; Kurz L; Liu K; Martin DP; McDermott A
    Biochemistry; 1999 Jun; 38(25):8022-31. PubMed ID: 10387046
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Acetyl-CoA enolization in citrate synthase: a quantum mechanical/molecular mechanical (QM/MM) study.
    Mulholland AJ; Richards WG
    Proteins; 1997 Jan; 27(1):9-25. PubMed ID: 9037708
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The thiolase reaction mechanism: the importance of Asn316 and His348 for stabilizing the enolate intermediate of the Claisen condensation.
    Meriläinen G; Poikela V; Kursula P; Wierenga RK
    Biochemistry; 2009 Nov; 48(46):11011-25. PubMed ID: 19842716
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Catalytic strategy of citrate synthase: effects of amino acid changes in the acetyl-CoA binding site on transition-state analog inhibitor complexes.
    Kurz LC; Drysdale GR; Riley MC; Evans CT; Srere PA
    Biochemistry; 1992 Sep; 31(34):7908-14. PubMed ID: 1324723
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Evaluation of 3-hydroxy-3-methylglutaryl-coenzyme A lyase arginine-41 as a catalytic residue: use of acetyldithio-coenzyme A to monitor product enolization.
    Tuinstra RL; Wang CZ; Mitchell GA; Miziorko HM
    Biochemistry; 2004 May; 43(18):5287-95. PubMed ID: 15122894
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Photophysics of tryptophan fluorescence: link with the catalytic strategy of the citrate synthase from Thermoplasma acidophilum.
    Kurz LC; Fite B; Jean J; Park J; Erpelding T; Callis P
    Biochemistry; 2005 Feb; 44(5):1394-413. PubMed ID: 15683225
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Ab initio QM/MM modelling of acetyl-CoA deprotonation in the enzyme citrate synthase.
    van der Kamp MW; Perruccio F; Mulholland AJ
    J Mol Graph Model; 2007 Oct; 26(3):676-90. PubMed ID: 17493853
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Evidence for the interaction of avian 3-hydroxy-3-methylglutaryl-CoA synthase histidine 264 with acetoacetyl-CoA.
    Misra I; Miziorko HM
    Biochemistry; 1996 Jul; 35(29):9610-6. PubMed ID: 8755743
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The partial substrate dethiaacetyl-coenzyme A mimics all critical carbon acid reactions in the condensation half-reaction catalyzed by Thermoplasma acidophilum citrate synthase.
    Kurz LC; Constantine CZ; Jiang H; Kappock TJ
    Biochemistry; 2009 Aug; 48(33):7878-91. PubMed ID: 19645419
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Thermodynamics of ligand binding and catalysis in human liver medium-chain acyl-CoA dehydrogenase: comparative studies involving normal and 3'-dephosphorylated C8-CoAs and wild-type and Asn191 --> Ala (N191A) mutant enzymes.
    Peterson KL; Peterson KM; Srivastava DK
    Biochemistry; 1998 Sep; 37(36):12659-71. PubMed ID: 9730839
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Probing hydrogen-bonding interactions in the active site of medium-chain acyl-CoA dehydrogenase using Raman spectroscopy.
    Wu J; Bell AF; Luo L; Stephens AW; Stankovich MT; Tonge PJ
    Biochemistry; 2003 Oct; 42(40):11846-56. PubMed ID: 14529297
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Proposed mechanism for the condensation reaction of citrate synthase: 1.9-A structure of the ternary complex with oxaloacetate and carboxymethyl coenzyme A.
    Karpusas M; Branchaud B; Remington SJ
    Biochemistry; 1990 Mar; 29(9):2213-9. PubMed ID: 2337600
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Proton uptake accompanies formation of the ternary complex of citrate synthase, oxaloacetate, and the transition-state analog inhibitor, carboxymethyl-CoA. Evidence that a neutral enol is the activated form of acetyl-CoA in the citrate synthase reaction.
    Kurz LC; Shah S; Crane BR; Donald LJ; Duckworth HW; Drysdale GR
    Biochemistry; 1992 Sep; 31(34):7899-907. PubMed ID: 1324722
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The mechanism of citryl-coenzyme A formation catalyzed by citrate synthase.
    Aleksandrov A; Zvereva E; Field M
    J Phys Chem B; 2014 May; 118(17):4505-13. PubMed ID: 24720842
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 23.