206 related articles for article (PubMed ID: 9666482)
1. Stable association of presenilin derivatives and absence of presenilin interactions with APP.
Thinakaran G; Regard JB; Bouton CM; Harris CL; Price DL; Borchelt DR; Sisodia SS
Neurobiol Dis; 1998 Apr; 4(6):438-53. PubMed ID: 9666482
[TBL] [Abstract][Full Text] [Related]
2. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
Xia W; Zhang J; Ostaszewski BL; Kimberly WT; Seubert P; Koo EH; Shen J; Selkoe DJ
Biochemistry; 1998 Nov; 37(47):16465-71. PubMed ID: 9843412
[TBL] [Abstract][Full Text] [Related]
3. Mapping the APP/presenilin (PS) binding domains: the hydrophilic N-terminus of PS2 is sufficient for interaction with APP and can displace APP/PS1 interaction.
Pradier L; Carpentier N; Delalonde L; Clavel N; Bock MD; Buée L; Mercken L; Tocqué B; Czech C
Neurobiol Dis; 1999 Feb; 6(1):43-55. PubMed ID: 10078972
[TBL] [Abstract][Full Text] [Related]
4. Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue.
Podlisny MB; Citron M; Amarante P; Sherrington R; Xia W; Zhang J; Diehl T; Levesque G; Fraser P; Haass C; Koo EH; Seubert P; St George-Hyslop P; Teplow DB; Selkoe DJ
Neurobiol Dis; 1997; 3(4):325-37. PubMed ID: 9173929
[TBL] [Abstract][Full Text] [Related]
5. Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.
Walker ES; Martinez M; Brunkan AL; Goate A
J Neurochem; 2005 Jan; 92(2):294-301. PubMed ID: 15663477
[TBL] [Abstract][Full Text] [Related]
6. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
[TBL] [Abstract][Full Text] [Related]
7. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
Li YM; Xu M; Lai MT; Huang Q; Castro JL; DiMuzio-Mower J; Harrison T; Lellis C; Nadin A; Neduvelil JG; Register RB; Sardana MK; Shearman MS; Smith AL; Shi XP; Yin KC; Shafer JA; Gardell SJ
Nature; 2000 Jun; 405(6787):689-94. PubMed ID: 10864326
[TBL] [Abstract][Full Text] [Related]
8. Presenilin 2 expression in neuronal cells: induction during differentiation of embryonic carcinoma cells.
Culvenor JG; Evin G; Cooney MA; Wardan H; Sharples RA; Maher F; Reed G; Diehlmann A; Weidemann A; Beyreuther K; Masters CL
Exp Cell Res; 2000 Mar; 255(2):192-206. PubMed ID: 10694435
[TBL] [Abstract][Full Text] [Related]
9. Presenilins are not required for A beta 42 production in the early secretory pathway.
Wilson CA; Doms RW; Zheng H; Lee VM
Nat Neurosci; 2002 Sep; 5(9):849-55. PubMed ID: 12145638
[TBL] [Abstract][Full Text] [Related]
10. Presenilin dependence of phospholipase C and protein kinase C signaling.
Dehvari N; Cedazo-Minguez A; Isacsson O; Nilsson T; Winblad B; Karlström H; Benedikz E; Cowburn RF
J Neurochem; 2007 Aug; 102(3):848-57. PubMed ID: 17437536
[TBL] [Abstract][Full Text] [Related]
11. Presenilin-1-mediated retention of APP derivatives in early biosynthetic compartments.
Réchards M; Xia W; Oorschot V; van Dijk S; Annaert W; Selkoe DJ; Klumperman J
Traffic; 2006 Mar; 7(3):354-64. PubMed ID: 16497228
[TBL] [Abstract][Full Text] [Related]
12. Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.
Shimojo M; Sahara N; Murayama M; Ichinose H; Takashima A
Neurosci Res; 2007 Mar; 57(3):446-53. PubMed ID: 17210196
[TBL] [Abstract][Full Text] [Related]
13. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
Xia W; Ostaszewski BL; Kimberly WT; Rahmati T; Moore CL; Wolfe MS; Selkoe DJ
Neurobiol Dis; 2000 Dec; 7(6 Pt B):673-81. PubMed ID: 11114265
[TBL] [Abstract][Full Text] [Related]
14. Presenilin 1 binds to amyloid precursor protein directly.
Waragai M; Imafuku I; Takeuchi S; Kanazawa I; Oyama F; Udagawa Y; Kawabata M; Okazawa H
Biochem Biophys Res Commun; 1997 Oct; 239(2):480-2. PubMed ID: 9344855
[TBL] [Abstract][Full Text] [Related]
15. Determination of a cleavage site of presenilin 2 protein in stably transfected SH-SY5Y human neuroblastoma cell lines.
Shirotani K; Takahashi K; Ozawa K; Kunishita T; Tabira T
Biochem Biophys Res Commun; 1997 Nov; 240(3):728-31. PubMed ID: 9398634
[TBL] [Abstract][Full Text] [Related]
16. Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation.
Crystal AS; Morais VA; Fortna RR; Carlin D; Pierson TC; Wilson CA; Lee VM; Doms RW
Biochemistry; 2004 Mar; 43(12):3555-63. PubMed ID: 15035625
[TBL] [Abstract][Full Text] [Related]
17. Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.
Citron M; Eckman CB; Diehl TS; Corcoran C; Ostaszewski BL; Xia W; Levesque G; St George Hyslop P; Younkin SG; Selkoe DJ
Neurobiol Dis; 1998 Aug; 5(2):107-16. PubMed ID: 9746908
[TBL] [Abstract][Full Text] [Related]
18. Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice.
Tournoy J; Bossuyt X; Snellinx A; Regent M; Garmyn M; Serneels L; Saftig P; Craessaerts K; De Strooper B; Hartmann D
Hum Mol Genet; 2004 Jul; 13(13):1321-31. PubMed ID: 15128703
[TBL] [Abstract][Full Text] [Related]
19. gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity.
Strömberg K; Hansson EM; Laudon H; Bergstedt S; Näslund J; Lundkvist J; Lendahl U
J Neurochem; 2005 Nov; 95(3):880-90. PubMed ID: 16135086
[TBL] [Abstract][Full Text] [Related]
20. C-terminal maturation fragments of presenilin 1 and 2 control secretion of APP alpha and A beta by human cells and are degraded by proteasome.
da Costa CA; Ancolio K; Checler F
Mol Med; 1999 Mar; 5(3):160-8. PubMed ID: 10404513
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
