BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

208 related articles for article (PubMed ID: 9668088)

  • 1. Acylation of naturally occurring and synthetic 1-deoxysphinganines by ceramide synthase. Formation of N-palmitoyl-aminopentol produces a toxic metabolite of hydrolyzed fumonisin, AP1, and a new category of ceramide synthase inhibitor.
    Humpf HU; Schmelz EM; Meredith FI; Vesper H; Vales TR; Wang E; Menaldino DS; Liotta DC; Merrill AH
    J Biol Chem; 1998 Jul; 273(30):19060-4. PubMed ID: 9668088
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Induction of apoptosis by fumonisin B1 in HT29 cells is mediated by the accumulation of endogenous free sphingoid bases.
    Schmelz EM; Dombrink-Kurtzman MA; Roberts PC; Kozutsumi Y; Kawasaki T; Merrill AH
    Toxicol Appl Pharmacol; 1998 Feb; 148(2):252-60. PubMed ID: 9473533
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Sphingolipid metabolism: roles in signal transduction and disruption by fumonisins.
    Merrill AH; Sullards MC; Wang E; Voss KA; Riley RT
    Environ Health Perspect; 2001 May; 109 Suppl 2(Suppl 2):283-9. PubMed ID: 11359697
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Hydrolyzed fumonisins HFB1 and HFB2 are acylated in vitro and in vivo by ceramide synthase to form cytotoxic N-acyl-metabolites.
    Seiferlein M; Humpf HU; Voss KA; Sullards MC; Allegood JC; Wang E; Merrill AH
    Mol Nutr Food Res; 2007 Sep; 51(9):1120-30. PubMed ID: 17729221
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Mycotoxin-induced elevation of free sphingoid bases in precision-cut rat liver slices: specificity of the response and structure-activity relationships.
    Norred WP; Plattner RD; Dombrink-Kurtzman MA; Meredith FI; Riley RT
    Toxicol Appl Pharmacol; 1997 Nov; 147(1):63-70. PubMed ID: 9356308
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Fumonisins and fumonisin analogs as inhibitors of ceramide synthase and inducers of apoptosis.
    Desai K; Sullards MC; Allegood J; Wang E; Schmelz EM; Hartl M; Humpf HU; Liotta DC; Peng Q; Merrill AH
    Biochim Biophys Acta; 2002 Dec; 1585(2-3):188-92. PubMed ID: 12531553
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Fumonisin-induced tumor necrosis factor-alpha expression in a porcine kidney cell line is independent of sphingoid base accumulation induced by ceramide synthase inhibition.
    He Q; Riley RT; Sharma RP
    Toxicol Appl Pharmacol; 2001 Jul; 174(1):69-77. PubMed ID: 11437650
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inhibition of sphingolipid biosynthesis in rat primary hepatocyte cultures by fumonisin B1 and other structurally related compounds.
    van der Westhuizen L; Shephard GS; Snyman SD; Abel S; Swanevelder S; Gelderblom WC
    Food Chem Toxicol; 1998 Jun; 36(6):497-503. PubMed ID: 9674957
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Instability of N-acetylated fumonisin B1 (FA1) and the impact on inhibition of ceramide synthase in rat liver slices.
    Norred WP; Riley RT; Meredith FI; Poling SM; Plattner RD
    Food Chem Toxicol; 2001 Nov; 39(11):1071-8. PubMed ID: 11527566
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Fumonisin B1 consumption by rats causes reversible, dose-dependent increases in urinary sphinganine and sphingosine.
    Wang E; Riley RT; Meredith FI; Merrill AH
    J Nutr; 1999 Jan; 129(1):214-20. PubMed ID: 9915902
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Disruption of sphingolipid metabolism and stimulation of DNA synthesis by fumonisin B1. A molecular mechanism for carcinogenesis associated with Fusarium moniliforme.
    Schroeder JJ; Crane HM; Xia J; Liotta DC; Merrill AH
    J Biol Chem; 1994 Feb; 269(5):3475-81. PubMed ID: 8106389
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase.
    El Bawab S; Birbes H; Roddy P; Szulc ZM; Bielawska A; Hannun YA
    J Biol Chem; 2001 May; 276(20):16758-66. PubMed ID: 11278489
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Ceramide synthase inhibition by fumonisins: a perfect storm of perturbed sphingolipid metabolism, signaling, and disease.
    Riley RT; Merrill AH
    J Lipid Res; 2019 Jul; 60(7):1183-1189. PubMed ID: 31048407
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Identification of N-acyl-fumonisin B1 as new cytotoxic metabolites of fumonisin mycotoxins.
    Harrer H; Laviad EL; Humpf HU; Futerman AH
    Mol Nutr Food Res; 2013 Mar; 57(3):516-22. PubMed ID: 23281112
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Sphingolipid perturbations as mechanisms for fumonisin carcinogenesis.
    Riley RT; Enongene E; Voss KA; Norred WP; Meredith FI; Sharma RP; Spitsbergen J; Williams DE; Carlson DB; Merrill AH
    Environ Health Perspect; 2001 May; 109 Suppl 2(Suppl 2):301-8. PubMed ID: 11359699
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Sphingoid bases and their phosphates: transient activation and delayed repression of protein kinase C isoforms and their possible involvement in fumonisin B1 cytotoxicity.
    Gopee NV; Sharma RP
    Toxicology; 2003 May; 187(2-3):239-50. PubMed ID: 12699912
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Analysis of fumonisin B1-induced apoptosis.
    Jones C; Ciacci-Zanella JR; Zhang Y; Henderson G; Dickman M
    Environ Health Perspect; 2001 May; 109 Suppl 2(Suppl 2):315-20. PubMed ID: 11359701
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Persistence and reversibility of the elevation in free sphingoid bases induced by fumonisin inhibition of ceramide synthase.
    Enongene EN; Sharma RP; Bhandari N; Miller JD; Meredith FI; Voss KA; Riley RT
    Toxicol Sci; 2002 Jun; 67(2):173-81. PubMed ID: 12011476
    [TBL] [Abstract][Full Text] [Related]  

  • 19. DNA damage in astrocytes exposed to fumonisin B1.
    Galvano F; Campisi A; Russo A; Galvano G; Palumbo M; Renis M; Barcellona ML; Perez-Polo JR; Vanella A
    Neurochem Res; 2002 Apr; 27(4):345-51. PubMed ID: 11958538
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Mechanisms of Fumonisin B1 Toxicity: A Computational Perspective beyond the Ceramide Synthases Inhibition.
    Dellafiora L; Galaverna G; Dall'Asta C
    Chem Res Toxicol; 2018 Nov; 31(11):1203-1212. PubMed ID: 30346146
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.