These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
138 related articles for article (PubMed ID: 9677373)
1. Functional characteristics of the oxyanion hole in human acetylcholinesterase. Ordentlich A; Barak D; Kronman C; Ariel N; Segall Y; Velan B; Shafferman A J Biol Chem; 1998 Jul; 273(31):19509-17. PubMed ID: 9677373 [TBL] [Abstract][Full Text] [Related]
2. The architecture of human acetylcholinesterase active center probed by interactions with selected organophosphate inhibitors. Ordentlich A; Barak D; Kronman C; Ariel N; Segall Y; Velan B; Shafferman A J Biol Chem; 1996 May; 271(20):11953-62. PubMed ID: 8662593 [TBL] [Abstract][Full Text] [Related]
3. Does "butyrylization" of acetylcholinesterase through substitution of the six divergent aromatic amino acids in the active center gorge generate an enzyme mimic of butyrylcholinesterase? Kaplan D; Ordentlich A; Barak D; Ariel N; Kronman C; Velan B; Shafferman A Biochemistry; 2001 Jun; 40(25):7433-45. PubMed ID: 11412096 [TBL] [Abstract][Full Text] [Related]
4. Exploring the active center of human acetylcholinesterase with stereomers of an organophosphorus inhibitor with two chiral centers. Ordentlich A; Barak D; Kronman C; Benschop HP; De Jong LP; Ariel N; Barak R; Segall Y; Velan B; Shafferman A Biochemistry; 1999 Mar; 38(10):3055-66. PubMed ID: 10074358 [TBL] [Abstract][Full Text] [Related]
5. Accommodation of physostigmine and its analogues by acetylcholinesterase is dominated by hydrophobic interactions. Barak D; Ordentlich A; Stein D; Yu QS; Greig NH; Shafferman A Biochem J; 2009 Jan; 417(1):213-22. PubMed ID: 18729824 [TBL] [Abstract][Full Text] [Related]
6. The role of AChE active site gorge in determining stereoselectivity of charged and noncharged VX enantiomers. Ordentlich A; Barak D; Sod-Moriah G; Kaplan D; Mizrahi D; Segall Y; Kronman C; Karton Y; Lazar A; Marcus D; Velan B; Shafferman A Chem Biol Interact; 2005 Dec; 157-158():191-8. PubMed ID: 16289014 [TBL] [Abstract][Full Text] [Related]
7. Functional requirements for the optimal catalytic configuration of the AChE active center. Shafferman A; Barak D; Kaplan D; Ordentlich A; Kronman C; Velan B Chem Biol Interact; 2005 Dec; 157-158():123-31. PubMed ID: 16256968 [TBL] [Abstract][Full Text] [Related]
8. Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket. Ordentlich A; Barak D; Kronman C; Flashner Y; Leitner M; Segall Y; Ariel N; Cohen S; Velan B; Shafferman A J Biol Chem; 1993 Aug; 268(23):17083-95. PubMed ID: 8349597 [TBL] [Abstract][Full Text] [Related]
9. Is aromaticity essential for trapping the catalytic histidine 447 in human acetylcholinesterase? Kaplan D; Barak D; Ordentlich A; Kronman C; Velan B; Shafferman A Biochemistry; 2004 Mar; 43(11):3129-36. PubMed ID: 15023064 [TBL] [Abstract][Full Text] [Related]
10. Contribution of aromatic moieties of tyrosine 133 and of the anionic subsite tryptophan 86 to catalytic efficiency and allosteric modulation of acetylcholinesterase. Ordentlich A; Barak D; Kronman C; Ariel N; Segall Y; Velan B; Shafferman A J Biol Chem; 1995 Feb; 270(5):2082-91. PubMed ID: 7836436 [TBL] [Abstract][Full Text] [Related]
11. The 'aromatic patch' of three proximal residues in the human acetylcholinesterase active centre allows for versatile interaction modes with inhibitors. Ariel N; Ordentlich A; Barak D; Bino T; Velan B; Shafferman A Biochem J; 1998 Oct; 335 ( Pt 1)(Pt 1):95-102. PubMed ID: 9742217 [TBL] [Abstract][Full Text] [Related]
12. Stereoselectivity toward VX is determined by interactions with residues of the acyl pocket as well as of the peripheral anionic site of AChE. Ordentlich A; Barak D; Sod-Moriah G; Kaplan D; Mizrahi D; Segall Y; Kronman C; Karton Y; Lazar A; Marcus D; Velan B; Shafferman A Biochemistry; 2004 Sep; 43(35):11255-65. PubMed ID: 15366935 [TBL] [Abstract][Full Text] [Related]
13. Lessons from functional analysis of AChE covalent and noncovalent inhibitors for design of AD therapeutic agents. Barak D; Ordentlich A; Kaplan D; Kronman C; Velan B; Shafferman A Chem Biol Interact; 2005 Dec; 157-158():219-26. PubMed ID: 16289124 [TBL] [Abstract][Full Text] [Related]
14. Mechanism of oxime reactivation of acetylcholinesterase analyzed by chirality and mutagenesis. Wong L; Radic Z; Brüggemann RJ; Hosea N; Berman HA; Taylor P Biochemistry; 2000 May; 39(19):5750-7. PubMed ID: 10801325 [TBL] [Abstract][Full Text] [Related]
15. Interactions of oxime reactivators with diethylphosphoryl adducts of human acetylcholinesterase and its mutant derivatives. Grosfeld H; Barak D; Ordentlich A; Velan B; Shafferman A Mol Pharmacol; 1996 Sep; 50(3):639-49. PubMed ID: 8794905 [TBL] [Abstract][Full Text] [Related]
16. Allosteric modulation of acetylcholinesterase activity by peripheral ligands involves a conformational transition of the anionic subsite. Barak D; Ordentlich A; Bromberg A; Kronman C; Marcus D; Lazar A; Ariel N; Velan B; Shafferman A Biochemistry; 1995 Nov; 34(47):15444-52. PubMed ID: 7492545 [TBL] [Abstract][Full Text] [Related]
17. The aromatic "trapping" of the catalytic histidine is essential for efficient catalysis in acetylcholinesterase. Barak D; Kaplan D; Ordentlich A; Ariel N; Velan B; Shafferman A Biochemistry; 2002 Jul; 41(26):8245-52. PubMed ID: 12081473 [TBL] [Abstract][Full Text] [Related]
18. Structure-reactivity relationships for the inhibition mechanism at the second alkyl-chain-binding site of cholesterol esterase and lipase. Lin G; Shieh CT; Ho HC; Chouhwang JY; Lin WY; Lu CP Biochemistry; 1999 Aug; 38(31):9971-81. PubMed ID: 10433704 [TBL] [Abstract][Full Text] [Related]
19. Engineering resistance to 'aging' of phosphylated human acetylcholinesterase. Role of hydrogen bond network in the active center. Ordentlich A; Kronman C; Barak D; Stein D; Ariel N; Marcus D; Velan B; Shafferman A FEBS Lett; 1993 Nov; 334(2):215-20. PubMed ID: 8224249 [TBL] [Abstract][Full Text] [Related]
20. Acetylcholinesterase peripheral anionic site degeneracy conferred by amino acid arrays sharing a common core. Barak D; Kronman C; Ordentlich A; Ariel N; Bromberg A; Marcus D; Lazar A; Velan B; Shafferman A J Biol Chem; 1994 Mar; 269(9):6296-305. PubMed ID: 8119978 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]