BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

103 related articles for article (PubMed ID: 9688535)

  • 1. Membrane-type 1 MMP (MMP-14) cleaves at three sites in the aggrecan interglobular domain.
    Fosang AJ; Last K; Fujii Y; Seiki M; Okada Y
    FEBS Lett; 1998 Jul; 430(3):186-90. PubMed ID: 9688535
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan substrate rAgg1mut at the 'aggrecanase' and the MMP sites. Characterization of MT1-MMP catabolic activities on the interglobular domain of aggrecan.
    Büttner FH; Hughes CE; Margerie D; Lichte A; Tschesche H; Caterson B; Bartnik E
    Biochem J; 1998 Jul; 333 ( Pt 1)(Pt 1):159-65. PubMed ID: 9639575
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Development of a cleavage-site-specific monoclonal antibody for detecting metalloproteinase-derived aggrecan fragments: detection of fragments in human synovial fluids.
    Fosang AJ; Last K; Gardiner P; Jackson DC; Brown L
    Biochem J; 1995 Aug; 310 ( Pt 1)(Pt 1):337-43. PubMed ID: 7544117
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B.
    Fosang AJ; Neame PJ; Last K; Hardingham TE; Murphy G; Hamilton JA
    J Biol Chem; 1992 Sep; 267(27):19470-4. PubMed ID: 1326552
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Mutations in the interglobular domain of aggrecan alter matrix metalloproteinase and aggrecanase cleavage patterns. Evidence that matrix metalloproteinase cleavage interferes with aggrecanase activity.
    Mercuri FA; Maciewicz RA; Tart J; Last K; Fosang AJ
    J Biol Chem; 2000 Oct; 275(42):33038-45. PubMed ID: 11032846
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan.
    Fosang AJ; Last K; Neame PJ; Murphy G; Knäuper V; Tschesche H; Hughes CE; Caterson B; Hardingham TE
    Biochem J; 1994 Dec; 304 ( Pt 2)(Pt 2):347-51. PubMed ID: 7998967
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Quantification of a matrix metalloproteinase-generated aggrecan G1 fragment using monospecific anti-peptide serum.
    Lark MW; Williams H; Hoernner LA; Weidner J; Ayala JM; Harper CF; Christen A; Olszewski J; Konteatis Z; Webber R
    Biochem J; 1995 Apr; 307 ( Pt 1)(Pt 1):245-52. PubMed ID: 7717983
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The interglobular domain of cartilage aggrecan is cleaved by hemorrhagic metalloproteinase HT-d (atrolysin C) at the matrix metalloproteinase and aggrecanase sites.
    Tortorella MD; Pratta MA; Fox JW; Arner EC
    J Biol Chem; 1998 Mar; 273(10):5846-50. PubMed ID: 9488721
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP).
    Stracke JO; Fosang AJ; Last K; Mercuri FA; Pendás AM; Llano E; Perris R; Di Cesare PE; Murphy G; Knäuper V
    FEBS Lett; 2000 Jul; 478(1-2):52-6. PubMed ID: 10922468
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Truncation of the amino-terminus of the recombinant aggrecan rAgg1mut leads to reduced cleavage at the aggrecanase site. Efficient aggrecanase catabolism may depend on multiple substrate interactions.
    Hörber C; Büttner FH; Kern C; Schmiedeknecht G; Bartnik E
    Matrix Biol; 2000 Nov; 19(6):533-43. PubMed ID: 11068207
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent.
    Fosang AJ; Last K; Maciewicz RA
    J Clin Invest; 1996 Nov; 98(10):2292-9. PubMed ID: 8941646
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4).
    Tortorella MD; Pratta M; Liu RQ; Austin J; Ross OH; Abbaszade I; Burn T; Arner E
    J Biol Chem; 2000 Jun; 275(24):18566-73. PubMed ID: 10751421
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Recombinant human aggrecan G1-G2 exhibits native binding properties and substrate specificity for matrix metalloproteinases and aggrecanase.
    Mercuri FA; Doege KJ; Arner EC; Pratta MA; Last K; Fosang AJ
    J Biol Chem; 1999 Nov; 274(45):32387-95. PubMed ID: 10542281
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain.
    Fosang AJ; Last K; Knäuper V; Neame PJ; Murphy G; Hardingham TE; Tschesche H; Hamilton JA
    Biochem J; 1993 Oct; 295 ( Pt 1)(Pt 1):273-6. PubMed ID: 8216228
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Degradation of cartilage aggrecan by collagenase-3 (MMP-13).
    Fosang AJ; Last K; Knäuper V; Murphy G; Neame PJ
    FEBS Lett; 1996 Feb; 380(1-2):17-20. PubMed ID: 8603731
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro.
    Hughes CE; Caterson B; Fosang AJ; Roughley PJ; Mort JS
    Biochem J; 1995 Feb; 305 ( Pt 3)(Pt 3):799-804. PubMed ID: 7531436
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Membrane-type matrix metalloproteinases 1 and 2 exhibit broad-spectrum proteolytic capacities comparable to many matrix metalloproteinases.
    d'Ortho MP; Will H; Atkinson S; Butler G; Messent A; Gavrilovic J; Smith B; Timpl R; Zardi L; Murphy G
    Eur J Biochem; 1997 Dec; 250(3):751-7. PubMed ID: 9461298
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.
    Little CB; Flannery CR; Hughes CE; Mort JS; Roughley PJ; Dent C; Caterson B
    Biochem J; 1999 Nov; 344 Pt 1(Pt 1):61-8. PubMed ID: 10548534
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Generation and novel distribution of matrix metalloproteinase-derived aggrecan fragments in porcine cartilage explants.
    Fosang AJ; Last K; Stanton H; Weeks DB; Campbell IK; Hardingham TE; Hembry RM
    J Biol Chem; 2000 Oct; 275(42):33027-37. PubMed ID: 10882746
    [TBL] [Abstract][Full Text] [Related]  

  • 20. ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan.
    Kuno K; Okada Y; Kawashima H; Nakamura H; Miyasaka M; Ohno H; Matsushima K
    FEBS Lett; 2000 Aug; 478(3):241-5. PubMed ID: 10930576
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.