BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

313 related articles for article (PubMed ID: 9692955)

  • 1. Cryocrystallography and microspectrophotometry of a mutant (alpha D60N) tryptophan synthase alpha 2 beta 2 complex reveals allosteric roles of alpha Asp60.
    Rhee S; Miles EW; Mozzarelli A; Davies DR
    Biochemistry; 1998 Jul; 37(30):10653-9. PubMed ID: 9692955
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Crystal structures of a mutant (betaK87T) tryptophan synthase alpha2beta2 complex with ligands bound to the active sites of the alpha- and beta-subunits reveal ligand-induced conformational changes.
    Rhee S; Parris KD; Hyde CC; Ahmed SA; Miles EW; Davies DR
    Biochemistry; 1997 Jun; 36(25):7664-80. PubMed ID: 9201907
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Affinities of phosphorylated substrates for the E. coli tryptophan synthase alpha-subunit: roles of Ser-235 and helix-8' dipole.
    Sarker KD; Hardman JK
    Proteins; 1995 Feb; 21(2):130-9. PubMed ID: 7777488
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Loop closure and intersubunit communication in tryptophan synthase.
    Schneider TR; Gerhardt E; Lee M; Liang PH; Anderson KS; Schlichting I
    Biochemistry; 1998 Apr; 37(16):5394-406. PubMed ID: 9548921
    [TBL] [Abstract][Full Text] [Related]  

  • 5. BetaQ114N and betaT110V mutations reveal a critically important role of the substrate alpha-carboxylate site in the reaction specificity of tryptophan synthase.
    Blumenstein L; Domratcheva T; Niks D; Ngo H; Seidel R; Dunn MF; Schlichting I
    Biochemistry; 2007 Dec; 46(49):14100-16. PubMed ID: 18004874
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Allosteric regulation of substrate channeling in tryptophan synthase: modulation of the L-serine reaction in stage I of the beta-reaction by alpha-site ligands.
    Ngo H; Kimmich N; Harris R; Niks D; Blumenstein L; Kulik V; Barends TR; Schlichting I; Dunn MF
    Biochemistry; 2007 Jul; 46(26):7740-53. PubMed ID: 17559232
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Cooperative fluctuations and subunit communication in tryptophan synthase.
    Bahar I; Jernigan RL
    Biochemistry; 1999 Mar; 38(12):3478-90. PubMed ID: 10090734
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Conformational changes in the alpha-subunit coupled to binding of the beta 2-subunit of tryptophan synthase from Escherichia coli: crystal structure of the tryptophan synthase alpha-subunit alone.
    Nishio K; Morimoto Y; Ishizuka M; Ogasahara K; Tsukihara T; Yutani K
    Biochemistry; 2005 Feb; 44(4):1184-92. PubMed ID: 15667212
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Circular dichroism studies of the coenzyme environment in the active sites of mutant forms of the beta-subunit in the tryptophan synthase alpha 2 beta 2 complex.
    Kayastha AM; Sawa Y; Nagata S; Kanzaki H; Miles EW
    Indian J Biochem Biophys; 1991; 28(5-6):352-7. PubMed ID: 1812066
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Allosteric regulation of tryptophan synthase channeling: the internal aldimine probed by trans-3-indole-3'-acrylate binding.
    Casino P; Niks D; Ngo H; Pan P; Brzovic P; Blumenstein L; Barends TR; Schlichting I; Dunn MF
    Biochemistry; 2007 Jul; 46(26):7728-39. PubMed ID: 17559231
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mutations in the contact region between the alpha and beta subunits of tryptophan synthase alter subunit interaction and intersubunit communication.
    Rowlett R; Yang LH; Ahmed SA; McPhie P; Jhee KH; Miles EW
    Biochemistry; 1998 Mar; 37(9):2961-8. PubMed ID: 9485448
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Allosteric communication in the tryptophan synthase bienzyme complex: roles of the beta-subunit aspartate 305-arginine 141 salt bridge.
    Ferrari D; Niks D; Yang LH; Miles EW; Dunn MF
    Biochemistry; 2003 Jul; 42(25):7807-18. PubMed ID: 12820890
    [TBL] [Abstract][Full Text] [Related]  

  • 13. beta-Site covalent reactions trigger transitions between open and closed conformations of the tryptophan synthase bienzyme complex.
    Pan P; Dunn MF
    Biochemistry; 1996 Apr; 35(15):5002-13. PubMed ID: 8664293
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Guanidine hydrochloride exerts dual effects on the tryptophan synthase alpha 2 beta 2 complex as a cation activator and as a modulator of the active site conformation.
    Fan YX; McPhie P; Miles EW
    Biochemistry; 1999 Jun; 38(24):7881-90. PubMed ID: 10387029
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Tryptophan synthase mutations that alter cofactor chemistry lead to mechanism-based inactivation.
    Jhee KH; McPhie P; Ro HS; Miles EW
    Biochemistry; 1998 Oct; 37(41):14591-604. PubMed ID: 9772188
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mechanisms of monovalent cation action in enzyme catalysis: the first stage of the tryptophan synthase beta-reaction.
    Woehl E; Dunn MF
    Biochemistry; 1999 Jun; 38(22):7118-30. PubMed ID: 10353822
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Allosteric regulation of tryptophan synthase: effects of pH, temperature, and alpha-subunit ligands on the equilibrium distribution of pyridoxal 5'-phosphate-L-serine intermediates.
    Peracchi A; Bettati S; Mozzarelli A; Rossi GL; Miles EW; Dunn MF
    Biochemistry; 1996 Feb; 35(6):1872-80. PubMed ID: 8639669
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Role of aspartate-133 and histidine-458 in the mechanism of tryptophan indole-lyase from Proteus vulgaris.
    Demidkina TV; Zakomirdina LN; Kulikova VV; Dementieva IS; Faleev NG; Ronda L; Mozzarelli A; Gollnick PD; Phillips RS
    Biochemistry; 2003 Sep; 42(38):11161-9. PubMed ID: 14503866
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Conformational Changes in the tryptophan synthase from a hyperthermophile upon alpha2beta2 complex formation: crystal structure of the complex.
    Lee SJ; Ogasahara K; Ma J; Nishio K; Ishida M; Yamagata Y; Tsukihara T; Yutani K
    Biochemistry; 2005 Aug; 44(34):11417-27. PubMed ID: 16114878
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structures of wild-type and P28L/Y173F tryptophan synthase alpha-subunits from Escherichia coli.
    Jeong MS; Jeong JK; Lim WK; Jang SB
    Biochem Biophys Res Commun; 2004 Oct; 323(4):1257-64. PubMed ID: 15451433
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.