185 related articles for article (PubMed ID: 9694871)
1. Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.
Tomita T; Tokuhiro S; Hashimoto T; Aiba K; Saido TC; Maruyama K; Iwatsubo T
J Biol Chem; 1998 Aug; 273(33):21153-60. PubMed ID: 9694871
[TBL] [Abstract][Full Text] [Related]
2. C terminus of presenilin is required for overproduction of amyloidogenic Abeta42 through stabilization and endoproteolysis of presenilin.
Tomita T; Takikawa R; Koyama A; Morohashi Y; Takasugi N; Saido TC; Maruyama K; Iwatsubo T
J Neurosci; 1999 Dec; 19(24):10627-34. PubMed ID: 10594046
[TBL] [Abstract][Full Text] [Related]
3. Subcellular compartment and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2.
Iwata H; Tomita T; Maruyama K; Iwatsubo T
J Biol Chem; 2001 Jun; 276(24):21678-85. PubMed ID: 11283011
[TBL] [Abstract][Full Text] [Related]
4. The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue.
Tomita T; Maruyama K; Saido TC; Kume H; Shinozaki K; Tokuhiro S; Capell A; Walter J; Grünberg J; Haass C; Iwatsubo T; Obata K
Proc Natl Acad Sci U S A; 1997 Mar; 94(5):2025-30. PubMed ID: 9050898
[TBL] [Abstract][Full Text] [Related]
5. The nonconserved hydrophilic loop domain of presenilin (PS) is not required for PS endoproteolysis or enhanced abeta 42 production mediated by familial early onset Alzheimer's disease-linked PS variants.
Saura CA; Tomita T; Soriano S; Takahashi M; Leem JY; Honda T; Koo EH; Iwatsubo T; Thinakaran G
J Biol Chem; 2000 Jun; 275(22):17136-42. PubMed ID: 10748144
[TBL] [Abstract][Full Text] [Related]
6. Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins.
Xia W; Zhang J; Kholodenko D; Citron M; Podlisny MB; Teplow DB; Haass C; Seubert P; Koo EH; Selkoe DJ
J Biol Chem; 1997 Mar; 272(12):7977-82. PubMed ID: 9065468
[TBL] [Abstract][Full Text] [Related]
7. Enhanced generation of intracellular Abeta42 amyloid peptide by mutation of presenilins PS1 and PS2.
Takeda K; Araki W; Tabira T
Eur J Neurosci; 2004 Jan; 19(2):258-264. PubMed ID: 14725619
[TBL] [Abstract][Full Text] [Related]
8. The influence of endoproteolytic processing of familial Alzheimer's disease presenilin 2 on abeta42 amyloid peptide formation.
Jacobsen H; Reinhardt D; Brockhaus M; Bur D; Kocyba C; Kurt H; Grim MG; Baumeister R; Loetscher H
J Biol Chem; 1999 Dec; 274(49):35233-9. PubMed ID: 10575009
[TBL] [Abstract][Full Text] [Related]
9. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
Xia W; Zhang J; Ostaszewski BL; Kimberly WT; Seubert P; Koo EH; Shen J; Selkoe DJ
Biochemistry; 1998 Nov; 37(47):16465-71. PubMed ID: 9843412
[TBL] [Abstract][Full Text] [Related]
10. Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain.
Oyama F; Sawamura N; Kobayashi K; Morishima-Kawashima M; Kuramochi T; Ito M; Tomita T; Maruyama K; Saido TC; Iwatsubo T; Capell A; Walter J; Grünberg J; Ueyama Y; Haass C; Ihara Y
J Neurochem; 1998 Jul; 71(1):313-22. PubMed ID: 9648880
[TBL] [Abstract][Full Text] [Related]
11. Enhancement of amyloid beta 42 secretion by 28 different presenilin 1 mutations of familial Alzheimer's disease.
Murayama O; Tomita T; Nihonmatsu N; Murayama M; Sun X; Honda T; Iwatsubo T; Takashima A
Neurosci Lett; 1999 Apr; 265(1):61-3. PubMed ID: 10327206
[TBL] [Abstract][Full Text] [Related]
12. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice.
Citron M; Westaway D; Xia W; Carlson G; Diehl T; Levesque G; Johnson-Wood K; Lee M; Seubert P; Davis A; Kholodenko D; Motter R; Sherrington R; Perry B; Yao H; Strome R; Lieberburg I; Rommens J; Kim S; Schenk D; Fraser P; St George Hyslop P; Selkoe DJ
Nat Med; 1997 Jan; 3(1):67-72. PubMed ID: 8986743
[TBL] [Abstract][Full Text] [Related]
13. A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling.
Steiner H; Duff K; Capell A; Romig H; Grim MG; Lincoln S; Hardy J; Yu X; Picciano M; Fechteler K; Citron M; Kopan R; Pesold B; Keck S; Baader M; Tomita T; Iwatsubo T; Baumeister R; Haass C
J Biol Chem; 1999 Oct; 274(40):28669-73. PubMed ID: 10497236
[TBL] [Abstract][Full Text] [Related]
14. Cytotoxic mechanisms by M239V presenilin 2, a little-analyzed Alzheimer's disease-causative mutant.
Abe Y; Hashimoto Y; Tomita Y; Terashita K; Aiso S; Tajima H; Niikura T; Matsuoka M; Nishimoto I
J Neurosci Res; 2004 Aug; 77(4):583-95. PubMed ID: 15264228
[TBL] [Abstract][Full Text] [Related]
15. Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
Mastrangelo P; Mathews PM; Chishti MA; Schmidt SD; Gu Y; Yang J; Mazzella MJ; Coomaraswamy J; Horne P; Strome B; Pelly H; Levesque G; Ebeling C; Jiang Y; Nixon RA; Rozmahel R; Fraser PE; St George-Hyslop P; Carlson GA; Westaway D
Proc Natl Acad Sci U S A; 2005 Jun; 102(25):8972-7. PubMed ID: 15951428
[TBL] [Abstract][Full Text] [Related]
16. Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis.
Leimer U; Lun K; Romig H; Walter J; Grünberg J; Brand M; Haass C
Biochemistry; 1999 Oct; 38(41):13602-9. PubMed ID: 10521267
[TBL] [Abstract][Full Text] [Related]
17. A pathogenic presenilin-1 deletion causes abberrant Abeta 42 production in the absence of congophilic amyloid plaques.
Steiner H; Revesz T; Neumann M; Romig H; Grim MG; Pesold B; Kretzschmar HA; Hardy J; Holton JL; Baumeister R; Houlden H; Haass C
J Biol Chem; 2001 Mar; 276(10):7233-9. PubMed ID: 11084029
[TBL] [Abstract][Full Text] [Related]
18. Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.
Steiner H; Capell A; Leimer U; Haass C
Eur Arch Psychiatry Clin Neurosci; 1999; 249(6):266-70. PubMed ID: 10653281
[TBL] [Abstract][Full Text] [Related]
19. Truncated presenilin 2 derived from differentially spliced mRNA does not affect the ratio of amyloid beta-peptide 1-42/1-40.
Grünberg J; Walter J; Eckman C; Capell A; Schindzielorz A; Younkin S; Mehta N; Hardy J; Haass C
Neuroreport; 1998 Oct; 9(14):3293-9. PubMed ID: 9831466
[TBL] [Abstract][Full Text] [Related]
20. Abeta42, presenilins, and Alzheimer's disease.
Iwatsubo T
Neurobiol Aging; 1998; 19(1 Suppl):S11-3. PubMed ID: 9562460
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]