BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

129 related articles for article (PubMed ID: 9698077)

  • 21. UCN-01 (7-hydroxystaurosporine) enhances 5-fluorouracil cytotoxicity through down-regulation of thymidylate synthetase messenger RNA.
    Abe S; Kubota T; Otani Y; Furukawa T; Watanabe M; Kumai K; Kitajima M
    Jpn J Cancer Res; 2000 Nov; 91(11):1192-8. PubMed ID: 11092986
    [TBL] [Abstract][Full Text] [Related]  

  • 22. The transfection of thymidylate synthase antisense suppresses oncogenic properties of a human colon cancer cell line and augments the antitumor effect of fluorouracil.
    Matsuoka K; Tsukuda K; Suda M; Kobayashi K; Ota T; Okita A; Watanabe K; Suzuki E; Murakami M; Doihara H; Shimizu N
    Int J Oncol; 2004 Jan; 24(1):217-22. PubMed ID: 14654960
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Intratumoral induction of thymidylate synthase mRNA by 5-FU in colorectal cancer patients: association with survival.
    Tanaka-Nozaki M; Tajiri T; Tanaka N; Furukawa K; Takasaki H; Yoshimura K; Suzuki H; Naito Z; Sugizaki Y; Merk HF; Blömeke B; Kato S
    Oncol Rep; 2003; 10(5):1425-9. PubMed ID: 12883718
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Overexpression of thymidylate synthase mediates desensitization for 5-fluorouracil of tumor cells.
    Saga Y; Suzuki M; Mizukami H; Kohno T; Takei Y; Fukushima M; Ozawa K
    Int J Cancer; 2003 Sep; 106(3):324-6. PubMed ID: 12845668
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Limits to thymidylate synthase and TP53 genes as predictive determinants for fluoropyrimidine sensitivity and further evidence for RNA-based toxicity as a major influence.
    Brody JR; Hucl T; Costantino CL; Eshleman JR; Gallmeier E; Zhu H; van der Heijden MS; Winter JM; Wikiewicz AK; Yeo CJ; Kern SE
    Cancer Res; 2009 Feb; 69(3):984-91. PubMed ID: 19155291
    [TBL] [Abstract][Full Text] [Related]  

  • 26. 5-fluorouracil-based chemotherapy enhances the antitumor activity of a thymidylate synthase-directed polyepitopic peptide vaccine.
    Correale P; Del Vecchio MT; Di Genova G; Savellini GG; La Placa M; Terrosi C; Vestri M; Urso R; Lemonnier F; Aquino A; Bonmassar E; Giorgi G; Francini G; Cusi MG
    J Natl Cancer Inst; 2005 Oct; 97(19):1437-45. PubMed ID: 16204693
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Downstream molecular determinants of response to 5-fluorouracil and antifolate thymidylate synthase inhibitors.
    Van Triest B; Pinedo HM; Giaccone G; Peters GJ
    Ann Oncol; 2000 Apr; 11(4):385-91. PubMed ID: 10847455
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Thymidine kinase, thymidylate synthase, and dihydropyrimidine dehydrogenase profiles of cell lines of the National Cancer Institute's Anticancer Drug Screen.
    Grem JL; Danenberg KD; Behan K; Parr A; Young L; Danenberg PV; Nguyen D; Drake J; Monks A; Allegra CJ
    Clin Cancer Res; 2001 Apr; 7(4):999-1009. PubMed ID: 11309351
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Thymidylate synthetase (TS) genotype and TS/dihydropyrimidine dehydrogenase mRNA level as an indicator in determining chemosensitivity to 5-fluorouracil in advanced gastric carcinoma.
    Toriumi F; Kubota T; Saikawa Y; Yoshida M; Otani Y; Watanabe M; Kumai K; Kitajima M
    Anticancer Res; 2004; 24(4):2455-63. PubMed ID: 15330198
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Comparison of thymidylate synthase (TS) protein up-regulation after exposure to TS inhibitors in normal and tumor cell lines and tissues.
    Welsh SJ; Titley J; Brunton L; Valenti M; Monaghan P; Jackman AL; Aherne GW
    Clin Cancer Res; 2000 Jun; 6(6):2538-46. PubMed ID: 10873110
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Significance of thymidylate synthase activity in renal cell carcinoma.
    Mizutani Y; Wada H; Yoshida O; Fukushima M; Nonomura M; Nakao M; Miki T
    Clin Cancer Res; 2003 Apr; 9(4):1453-60. PubMed ID: 12684419
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Prolonged and enhanced suppression of thymidylate synthase by weekly 24-h infusion of high-dose 5-fluorouracil.
    Yeh KH; Yeh SH; Hsu CH; Wang TM; Ma IF; Cheng AL
    Br J Cancer; 2000 Dec; 83(11):1510-5. PubMed ID: 11076661
    [TBL] [Abstract][Full Text] [Related]  

  • 33. The interaction of thymidylate synthase expression with p53-regulated signaling pathways in tumor cells.
    Longley DB; Latif T; Boyer J; Allen WL; Maxwell PJ; Johnston PG
    Semin Oncol; 2003 Jun; 30(3 Suppl 6):3-9. PubMed ID: 12802789
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Reduction of 5-fluorouracil (5-FU) gastrointestinal (GI) toxicity resulting from the protection of thymidylate synthase (TS) in GI tissue by repeated simultaneous administration of potassium oxonate (Oxo) in rats.
    Yoshisue K; Hironaga K; Yamaguchi S; Yamamoto A; Nagayama S; Kawaguchi Y
    Cancer Chemother Pharmacol; 2000; 46(1):51-6. PubMed ID: 10912578
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Correlations between thymidylate synthase expression and chemosensitivity to 5-fluorouracil, cell proliferation and clinical outcome in head and neck squamous cell carcinoma.
    Yasumatsu R; Nakashima T; Uryu H; Ayada T; Wakasaki T; Kogo R; Masuda M; Fukushima M; Komune S
    Chemotherapy; 2009; 55(1):36-41. PubMed ID: 19023200
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Polymorphism of the thymidylate synthase gene and thymidylate synthase levels in colon cancer cell lines and different tissues of colorectal cancer patients.
    Mauritz R; Beumer IJ; Marsh S; McLeod HL; Smid K; van Groeningen CJ; Pinedo HM; Peters GJ
    Nucleosides Nucleotides Nucleic Acids; 2004 Oct; 23(8-9):1381-4. PubMed ID: 15571263
    [TBL] [Abstract][Full Text] [Related]  

  • 37. The roles of thymidylate synthase and p53 in regulating Fas-mediated apoptosis in response to antimetabolites.
    Longley DB; Allen WL; McDermott U; Wilson TR; Latif T; Boyer J; Lynch M; Johnston PG
    Clin Cancer Res; 2004 May; 10(10):3562-71. PubMed ID: 15161716
    [TBL] [Abstract][Full Text] [Related]  

  • 38. [5-FU sensitivity and thymidylate synthase in gastric cancer].
    Suda Y; Uchida K; Shioya T; Tanaka Y; Kuwashima Y; Yano T
    Gan To Kagaku Ryoho; 1999 Dec; 26(14):2169-73. PubMed ID: 10635300
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Polymorphic tandem repeat sequences of the thymidylate synthase gene correlates with cellular-based sensitivity to fluoropyrimidine antitumor agents.
    Yawata A; Kim SR; Miyajima A; Kubo T; Ishida S; Saito Y; Nakajima Y; Katori N; Matsumoto Y; Fukuoka M; Ohno Y; Ozawa S; Sawada J
    Cancer Chemother Pharmacol; 2005 Nov; 56(5):465-72. PubMed ID: 15918040
    [TBL] [Abstract][Full Text] [Related]  

  • 40. High expression of thymidylate synthase is associated with the drug resistance of gastric carcinoma to high dose 5-fluorouracil-based systemic chemotherapy.
    Yeh KH; Shun CT; Chen CL; Lin JT; Lee WJ; Lee PH; Chen YC; Cheng AL
    Cancer; 1998 May; 82(9):1626-31. PubMed ID: 9576280
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 7.