289 related articles for article (PubMed ID: 9703322)
21. Identification and functional analysis of mutations in the hepatocyte nuclear factor-1alpha gene in anti-islet autoantibody-negative Japanese patients with type 1 diabetes.
Kawasaki E; Sera Y; Yamakawa K; Abe T; Ozaki M; Uotani S; Ohtsu N; Takino H; Yamasaki H; Yamaguchi Y; Matsuura N; Eguchi K
J Clin Endocrinol Metab; 2000 Jan; 85(1):331-5. PubMed ID: 10634407
[TBL] [Abstract][Full Text] [Related]
22. Evidence for haploinsufficiency of the human HNF1alpha gene revealed by functional characterization of MODY3-associated mutations.
Thomas H; Badenberg B; Bulman M; Lemm I; Lausen J; Kind L; Roosen S; Ellard S; Hattersley AT; Ryffel GU
Biol Chem; 2002 Nov; 383(11):1691-700. PubMed ID: 12530534
[TBL] [Abstract][Full Text] [Related]
23. HNF-1alpha and endodermal transcription factors cooperatively activate Fabpl: MODY3 mutations abrogate cooperativity.
Divine JK; McCaul SP; Simon TC
Am J Physiol Gastrointest Liver Physiol; 2003 Jul; 285(1):G62-72. PubMed ID: 12646418
[TBL] [Abstract][Full Text] [Related]
24. Identification of mutations in the hepatocyte nuclear factor (HNF)-1 alpha gene in Japanese subjects with IDDM.
Yamada S; Nishigori H; Onda H; Utsugi T; Yanagawa T; Maruyama T; Onigata K; Nagashima K; Nagai R; Morikawa A; Takeuchi T; Takeda J
Diabetes; 1997 Oct; 46(10):1643-7. PubMed ID: 9313763
[TBL] [Abstract][Full Text] [Related]
25. Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism.
Shih DQ; Screenan S; Munoz KN; Philipson L; Pontoglio M; Yaniv M; Polonsky KS; Stoffel M
Diabetes; 2001 Nov; 50(11):2472-80. PubMed ID: 11679424
[TBL] [Abstract][Full Text] [Related]
26. beta-cell genes and diabetes: molecular and clinical characterization of mutations in transcription factors.
Frayling TM; Evans JC; Bulman MP; Pearson E; Allen L; Owen K; Bingham C; Hannemann M; Shepherd M; Ellard S; Hattersley AT
Diabetes; 2001 Feb; 50 Suppl 1():S94-100. PubMed ID: 11272211
[TBL] [Abstract][Full Text] [Related]
27. Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line.
Wang H; Maechler P; Hagenfeldt KA; Wollheim CB
EMBO J; 1998 Nov; 17(22):6701-13. PubMed ID: 9822613
[TBL] [Abstract][Full Text] [Related]
28. High-resolution structure of the HNF-1alpha dimerization domain.
Rose RB; Endrizzi JA; Cronk JD; Holton J; Alber T
Biochemistry; 2000 Dec; 39(49):15062-70. PubMed ID: 11106484
[TBL] [Abstract][Full Text] [Related]
29. Hepatocyte nuclear factor-1alpha inhibits insulin promoter factor 1-dependent transactivation of the human insulin gene.
Yamakawa K; Yamasaki H; Ozaki M; Yamauchi MD; Fujita N; Abe T; Miyazoe H; Sera Y; Uotani S; Kawasaki E; Takino H; Yamaguchi Y; Eguchi K
Endocr Res; 2001; 27(1-2):63-74. PubMed ID: 11428722
[TBL] [Abstract][Full Text] [Related]
30. Identification of seven novel nucleotide variants in the hepatocyte nuclear factor-1alpha (TCF1) promoter region in MODY patients.
Godart F; Bellanné-Chantelot C; Clauin S; Gragnoli C; Abderrahmani A; Blanché H; Boutin P; Chèvre JC; Froguel P; Bailleul B
Hum Mutat; 2000; 15(2):173-80. PubMed ID: 10649494
[TBL] [Abstract][Full Text] [Related]
31. Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell function.
Hansen SK; Párrizas M; Jensen ML; Pruhova S; Ek J; Boj SF; Johansen A; Maestro MA; Rivera F; Eiberg H; Andel M; Lebl J; Pedersen O; Ferrer J; Hansen T
J Clin Invest; 2002 Sep; 110(6):827-33. PubMed ID: 12235114
[TBL] [Abstract][Full Text] [Related]
32. The dimerization domain of HNF-1alpha: structure and plasticity of an intertwined four-helix bundle with application to diabetes mellitus.
Narayana N; Hua Q; Weiss MA
J Mol Biol; 2001 Jul; 310(3):635-58. PubMed ID: 11439029
[TBL] [Abstract][Full Text] [Related]
33. Three new mutations in the hepatocyte nuclear factor-1alpha gene in Japanese subjects with diabetes mellitus: clinical features and functional characterization.
Yoshiuchi I; Yamagata K; Yang Q; Iwahashi H; Okita K; Yamamoto K; Oue T; Imagawa A; Hamaguchi T; Yamasaki T; Horikawa Y; Satoh T; Nakajima H; Miyazaki J; Higashiyama S; Miyagawa J; Namba M; Hanafusa T; Matsuzawa Y
Diabetologia; 1999 May; 42(5):621-6. PubMed ID: 10333057
[TBL] [Abstract][Full Text] [Related]
34. Expression profile of MODY3/HNF-1alpha protein in the developing mouse pancreas.
Nammo T; Yamagata K; Hamaoka R; Zhu Q; Akiyama TE; Gonzalez FJ; Miyagawa J; Matsuzawa Y
Diabetologia; 2002 Aug; 45(8):1142-53. PubMed ID: 12189445
[TBL] [Abstract][Full Text] [Related]
35. A rapid screening method for hepatocyte nuclear factor 1 alpha frameshift mutations; prevalence in maturity-onset diabetes of the young and late-onset non-insulin dependent diabetes.
Frayling TM; Bulman MP; Appleton M; Hattersley AT; Ellard S
Hum Genet; 1997 Dec; 101(3):351-4. PubMed ID: 9439666
[TBL] [Abstract][Full Text] [Related]
36. Novel MODY3 mutations in the hepatocyte nuclear factor-1alpha gene: evidence for a hyperexcitability of pancreatic beta-cells to intravenous secretagogues in a glucose-tolerant carrier of a P447L mutation.
Hansen T; Eiberg H; Rouard M; Vaxillaire M; Møller AM; Rasmussen SK; Fridberg M; Urhammer SA; Holst JJ; Almind K; Echwald SM; Hansen L; Bell GI; Pedersen O
Diabetes; 1997 Apr; 46(4):726-30. PubMed ID: 9075819
[TBL] [Abstract][Full Text] [Related]
37. Role of the hepatocyte nuclear factor-1beta (HNF-1beta) C-terminal domain in Pkhd1 (ARPKD) gene transcription and renal cystogenesis.
Hiesberger T; Shao X; Gourley E; Reimann A; Pontoglio M; Igarashi P
J Biol Chem; 2005 Mar; 280(11):10578-86. PubMed ID: 15647252
[TBL] [Abstract][Full Text] [Related]
38. Proposed mechanism for a novel insertion/deletion frameshift mutation (I414G415ATCG-->CCA) in the hepatocyte nuclear factor 1 alpha (HNF-1 alpha) gene which causes maturity-onset diabetes of the young (MODY).
Ellard S; Bulman MP; Frayling TM; Shepherd M; Hattersley AT
Hum Mutat; 2000 Sep; 16(3):273. PubMed ID: 10980542
[TBL] [Abstract][Full Text] [Related]
39. Messenger RNA transcripts of the hepatocyte nuclear factor-1alpha gene containing premature termination codons are subject to nonsense-mediated decay.
Harries LW; Hattersley AT; Ellard S
Diabetes; 2004 Feb; 53(2):500-4. PubMed ID: 14747304
[TBL] [Abstract][Full Text] [Related]
40. Molecular targets of a human HNF1 alpha mutation responsible for pancreatic beta-cell dysfunction.
Wang H; Antinozzi PA; Hagenfeldt KA; Maechler P; Wollheim CB
EMBO J; 2000 Aug; 19(16):4257-64. PubMed ID: 10944108
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
