These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

280 related articles for article (PubMed ID: 9707499)

  • 1. The roles of CYP3A and CYP2B isoforms in hepatic bioactivation and detoxification of the pyrrolizidine alkaloid senecionine in sheep and hamsters.
    Huan JY; Miranda CL; Buhler DR; Cheeke PR
    Toxicol Appl Pharmacol; 1998 Aug; 151(2):229-35. PubMed ID: 9707499
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The effect of spironolactone treatment on the cytochrome P450-mediated metabolism of the pyrrolizidine alkaloid senecionine by hepatic microsomes from rats and guinea pigs.
    Chung WG; Buhler DR
    Toxicol Appl Pharmacol; 1994 Aug; 127(2):314-9. PubMed ID: 8048076
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid.
    Wang YP; Yan J; Fu PP; Chou MW
    Toxicol Lett; 2005 Mar; 155(3):411-20. PubMed ID: 15649625
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Bioactivation and detoxication of the pyrrolizidine alkaloid senecionine by cytochrome P-450 enzymes in rat liver.
    Williams DE; Reed RL; Kedzierski B; Dannan GA; Guengerich FP; Buhler DR
    Drug Metab Dispos; 1989; 17(4):387-92. PubMed ID: 2571477
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Species differences in the hepatic microsomal enzyme metabolism of the pyrrolizidine alkaloids.
    Huan JY; Miranda CL; Buhler DR; Cheeke PR
    Toxicol Lett; 1998 Oct; 99(2):127-37. PubMed ID: 9817084
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Role of cytochrome P450IIIA4 in the metabolism of the pyrrolizidine alkaloid senecionine in human liver.
    Miranda CL; Reed RL; Guengerich FP; Buhler DR
    Carcinogenesis; 1991 Mar; 12(3):515-9. PubMed ID: 2009596
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Metabolism of phencyclidine by human liver microsomes.
    Laurenzana EM; Owens SM
    Drug Metab Dispos; 1997 May; 25(5):557-63. PubMed ID: 9152594
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Comparison of hepatic in vitro metabolism of the pyrrolizidine alkaloid senecionine in sheep and cattle.
    Duringer JM; Buhler DR; Craig AM
    Am J Vet Res; 2004 Nov; 65(11):1563-72. PubMed ID: 15566096
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Midazolam and triazolam biotransformation in mouse and human liver microsomes: relative contribution of CYP3A and CYP2C isoforms.
    Perloff MD; von Moltke LL; Court MH; Kotegawa T; Shader RI; Greenblatt DJ
    J Pharmacol Exp Ther; 2000 Feb; 292(2):618-28. PubMed ID: 10640299
    [TBL] [Abstract][Full Text] [Related]  

  • 10. In vitro complex formation and inhibition of hepatic cytochrome P450 activity by different macrolides and tiamulin in goats and cattle.
    Zweers-Zeilmaker WM; Van Miert AS; Horbach GJ; Witkamp RF
    Res Vet Sci; 1999 Feb; 66(1):51-5. PubMed ID: 10088712
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Evidence for CYP3A-mediated N-deethylation of amiodarone in human liver microsomal fractions.
    Fabre G; Julian B; Saint-Aubert B; Joyeux H; Berger Y
    Drug Metab Dispos; 1993; 21(6):978-85. PubMed ID: 7905403
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Major factors for the susceptibility of guinea pig to the pyrrolizidine alkaloid jacobine.
    Chung WG; Buhler DR
    Drug Metab Dispos; 1995 Nov; 23(11):1263-7. PubMed ID: 8591728
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A cytochrome P4502B form is the major bioactivation enzyme for the pyrrolizidine alkaloid senecionine in guinea pig.
    Chung WG; Miranda CL; Buhler DR
    Xenobiotica; 1995 Sep; 25(9):929-39. PubMed ID: 8553686
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Effects of antidepressant drugs on the activity of cytochrome P-450 measured by caffeine oxidation in rat liver microsomes.
    Danie WA; Syrek M; Ryłko Z; Wójcikowski J
    Pol J Pharmacol; 2001; 53(4):351-7. PubMed ID: 11990081
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Description of a 96-well plate assay to measure cytochrome P4503A inhibition in human liver microsomes using a selective fluorescent probe.
    Chauret N; Tremblay N; Lackman RL; Gauthier JY; Silva JM; Marois J; Yergey JA; Nicoll-Griffith DA
    Anal Biochem; 1999 Dec; 276(2):215-26. PubMed ID: 10603245
    [TBL] [Abstract][Full Text] [Related]  

  • 16. [Involvement of cytochrome P4503A in the monohydroxylation of ring A of praziquantel in rat liver microsomes].
    Zhang YJ; Quan YZ
    Yao Xue Xue Bao; 1997; 32(1):5-10. PubMed ID: 11243219
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Drug interactions with calcium channel blockers: possible involvement of metabolite-intermediate complexation with CYP3A.
    Ma B; Prueksaritanont T; Lin JH
    Drug Metab Dispos; 2000 Feb; 28(2):125-30. PubMed ID: 10640508
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Diltiazem inhibition of cytochrome P-450 3A activity is due to metabolite intermediate complex formation.
    Jones DR; Gorski JC; Hamman MA; Mayhew BS; Rider S; Hall SD
    J Pharmacol Exp Ther; 1999 Sep; 290(3):1116-25. PubMed ID: 10454485
    [TBL] [Abstract][Full Text] [Related]  

  • 19. CYP2C and CYP2B Mediated Metabolic Activation of Retrorsine in Cyp3a Knockout Mice.
    Pang X; Tang C; Kong F; Chen M; Chen X
    Curr Drug Metab; 2020; 21(13):1040-1051. PubMed ID: 33267758
    [TBL] [Abstract][Full Text] [Related]  

  • 20. In vivo antitumor activity and host toxicity of methoxymorpholinyl doxorubicin: role of cytochrome P450 3A.
    Quintieri L; Rosato A; Napoli E; Sola F; Geroni C; Floreani M; Zanovello P
    Cancer Res; 2000 Jun; 60(12):3232-8. PubMed ID: 10866316
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.