506 related articles for article (PubMed ID: 9724534)
1. Kinetic reaction scheme for the dihydrofolate reductase domain of the bifunctional thymidylate synthase-dihydrofolate reductase from Leishmania major.
Liang PH; Anderson KS
Biochemistry; 1998 Sep; 37(35):12206-12. PubMed ID: 9724534
[TBL] [Abstract][Full Text] [Related]
2. Substrate channeling and domain-domain interactions in bifunctional thymidylate synthase-dihydrofolate reductase.
Liang PH; Anderson KS
Biochemistry; 1998 Sep; 37(35):12195-205. PubMed ID: 9724533
[TBL] [Abstract][Full Text] [Related]
3. Probing the role of parasite-specific, distant structural regions on communication and catalysis in the bifunctional thymidylate synthase-dihydrofolate reductase from Plasmodium falciparum.
Dasgupta T; Anderson KS
Biochemistry; 2008 Feb; 47(5):1336-45. PubMed ID: 18189414
[TBL] [Abstract][Full Text] [Related]
4. Functional expression of the dihydrofolate reductase domain of Leishmania major dihydrofolate reductase-thymidylate synthase bifunctional protein.
Yu PL; Zhao J; Yu M; Reid R; Santi DV
Protein Expr Purif; 1996 Aug; 8(1):23-7. PubMed ID: 8812831
[TBL] [Abstract][Full Text] [Related]
5. Structures of dihydrofolate reductase-thymidylate synthase of Trypanosoma cruzi in the folate-free state and in complex with two antifolate drugs, trimetrexate and methotrexate.
Senkovich O; Schormann N; Chattopadhyay D
Acta Crystallogr D Biol Crystallogr; 2009 Jul; 65(Pt 7):704-16. PubMed ID: 19564691
[TBL] [Abstract][Full Text] [Related]
6. Heterologous expression and characterization of the bifunctional dihydrofolate reductase-thymidylate synthase enzyme of Toxoplasma gondii.
Trujillo M; Donald RG; Roos DS; Greene PJ; Santi DV
Biochemistry; 1996 May; 35(20):6366-74. PubMed ID: 8639582
[TBL] [Abstract][Full Text] [Related]
7. Homology modelling of the dihydrofolate reductase-thymidylate synthase bifunctional enzyme of Leishmania major, a potential target for rational drug design in leishmaniasis.
McKie JH
Drug Des Discov; 1994 Jun; 11(4):269-88. PubMed ID: 7727680
[TBL] [Abstract][Full Text] [Related]
8. First three-dimensional structure of Toxoplasma gondii thymidylate synthase-dihydrofolate reductase: insights for catalysis, interdomain interactions, and substrate channeling.
Sharma H; Landau MJ; Vargo MA; Spasov KA; Anderson KS
Biochemistry; 2013 Oct; 52(41):7305-7317. PubMed ID: 24053355
[TBL] [Abstract][Full Text] [Related]
9. Mechanistic characterization of Toxoplasma gondii thymidylate synthase (TS-DHFR)-dihydrofolate reductase. Evidence for a TS intermediate and TS half-sites reactivity.
Johnson EF; Hinz W; Atreya CE; Maley F; Anderson KS
J Biol Chem; 2002 Nov; 277(45):43126-36. PubMed ID: 12192007
[TBL] [Abstract][Full Text] [Related]
10. Structure of and kinetic channelling in bifunctional dihydrofolate reductase-thymidylate synthase.
Knighton DR; Kan CC; Howland E; Janson CA; Hostomska Z; Welsh KM; Matthews DA
Nat Struct Biol; 1994 Mar; 1(3):186-94. PubMed ID: 7656037
[TBL] [Abstract][Full Text] [Related]
11. Disruption of the crossover helix impairs dihydrofolate reductase activity in the bifunctional enzyme TS-DHFR from Cryptosporidium hominis.
Vargo MA; Martucci WE; Anderson KS
Biochem J; 2009 Feb; 417(3):757-64. PubMed ID: 18851711
[TBL] [Abstract][Full Text] [Related]
12. Understanding the molecular mechanism of substrate channeling and domain communication in protozoal bifunctional TS-DHFR.
Anderson KS
Protein Eng Des Sel; 2017 Mar; 30(3):253-261. PubMed ID: 28338744
[TBL] [Abstract][Full Text] [Related]
13. Kinetic characterization of bifunctional thymidylate synthase-dihydrofolate reductase (TS-DHFR) from Cryptosporidium hominis: a paradigm shift for ts activity and channeling behavior.
Atreya CE; Anderson KS
J Biol Chem; 2004 Apr; 279(18):18314-22. PubMed ID: 14966126
[TBL] [Abstract][Full Text] [Related]
14. Nonconserved residues Ala287 and Ser290 of the Cryptosporidium hominis thymidylate synthase domain facilitate its rapid rate of catalysis.
Doan LT; Martucci WE; Vargo MA; Atreya CE; Anderson KS
Biochemistry; 2007 Jul; 46(28):8379-91. PubMed ID: 17580969
[TBL] [Abstract][Full Text] [Related]
15. Subunit complementation of thymidylate synthase in Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase.
Chanama M; Chitnumsub P; Yuthavong Y
Mol Biochem Parasitol; 2005 Jan; 139(1):83-90. PubMed ID: 15610822
[TBL] [Abstract][Full Text] [Related]
16. Probing electrostatic channeling in protozoal bifunctional thymidylate synthase-dihydrofolate reductase using site-directed mutagenesis.
Atreya CE; Johnson EF; Williamson J; Chang SY; Liang PH; Anderson KS
J Biol Chem; 2003 Aug; 278(31):28901-11. PubMed ID: 12754260
[TBL] [Abstract][Full Text] [Related]
17. Electrostatic channeling of substrates between enzyme active sites: comparison of simulation and experiment.
Elcock AH; Huber GA; McCammon JA
Biochemistry; 1997 Dec; 36(51):16049-58. PubMed ID: 9405038
[TBL] [Abstract][Full Text] [Related]
18. Construction of a homodimeric dihydrofolate reductase-thymidylate synthase bifunctional enzyme.
Trujillo M; Duncan R; Santi DV
Protein Eng; 1997 May; 10(5):567-73. PubMed ID: 9215575
[TBL] [Abstract][Full Text] [Related]
19. Evidence for a functional role of the dynamics of glycine-121 of Escherichia coli dihydrofolate reductase obtained from kinetic analysis of a site-directed mutant.
Cameron CE; Benkovic SJ
Biochemistry; 1997 Dec; 36(50):15792-800. PubMed ID: 9398309
[TBL] [Abstract][Full Text] [Related]
20. Substrate channeling between the human dihydrofolate reductase and thymidylate synthase.
Wang N; McCammon JA
Protein Sci; 2016 Jan; 25(1):79-86. PubMed ID: 26096018
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
