BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

204 related articles for article (PubMed ID: 9733489)

  • 1. Synthesis and antitumor activity of 4-aminomethylthioxanthenone and 5-aminomethylbenzothiopyranoindazole derivatives.
    Perni RB; Wentland MP; Huang JI; Powles RG; Aldous S; Klingbeil KM; Peverly AD; Robinson RG; Corbett TH; Jones JL; Mattes KC; Rake JB; Coughlin SA
    J Med Chem; 1998 Sep; 41(19):3645-54. PubMed ID: 9733489
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Substitution at the F-ring N-imide of the indolocarbazole antitumor drug NB-506 increases the cytotoxicity, DNA binding, and topoisomerase I inhibition activities.
    Bailly C; Qu X; Chaires JB; Colson P; Houssier C; Ohkubo M; Nishimura S; Yoshinari T
    J Med Chem; 1999 Jul; 42(15):2927-35. PubMed ID: 10425102
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Antitumor agents. 194. Synthesis and biological evaluations of 4-beta-mono-, -di-, and -trisubstituted aniline-4'-O-demethyl-podophyllotoxin and related compounds with improved pharmacological profiles.
    Zhu XK; Guan J; Tachibana Y; Bastow KF; Cho SJ; Cheng HH; Cheng YC; Gurwith M; Lee KH
    J Med Chem; 1999 Jul; 42(13):2441-6. PubMed ID: 10395485
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Cytotoxic and DNA binding properties of aminoalkyl derivatives of di- and triazaphenanthrenes.
    Argiropoulos G; Bates MR; Cherubim P; Deady LW; Ganakas AM; Baguley BC; Denny WA
    Anticancer Drug Des; 1992 Aug; 7(4):285-96. PubMed ID: 1510798
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structure-activity relationships for substituted bis(acridine-4-carboxamides): a new class of anticancer agents.
    Gamage SA; Spicer JA; Atwell GJ; Finlay GJ; Baguley BC; Denny WA
    J Med Chem; 1999 Jul; 42(13):2383-93. PubMed ID: 10395479
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synthesis of mono- and bisdihydrodipyridopyrazines and assessment of their DNA binding and cytotoxic properties.
    Blanchard S; Rodriguez I; Tardy C; Baldeyrou B; Bailly C; Colson P; Houssier C; Léonce S; Kraus-Berthier L; Pfeiffer B; Renard P; Pierré A; Caubère P; Guillaumet G
    J Med Chem; 2004 Feb; 47(4):978-87. PubMed ID: 14761199
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and antitumor evaluation of 2,5-disubstituted-indazolo[4, 3-gh]isoquinolin-6(2H)-ones (9-aza-anthrapyrazoles).
    Krapcho AP; Menta E; Oliva A; Di Domenico R; Fiocchi L; Maresch ME; Gallagher CE; Hacker MP; Beggiolin G; Giuliani FC; Pezzoni G; Spinelli S
    J Med Chem; 1998 Dec; 41(27):5429-44. PubMed ID: 9876113
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group.
    Anizon F; Belin L; Moreau P; Sancelme M; Voldoire A; Prudhomme M; Ollier M; Sevère D; Riou JF; Bailly C; Fabbro D; Meyer T
    J Med Chem; 1997 Oct; 40(21):3456-65. PubMed ID: 9341921
    [TBL] [Abstract][Full Text] [Related]  

  • 9. 5,7-Disubstituted analogues of the mixed topoisomerase I/II poison N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (DACA): DNA binding and patterns of cytotoxicity.
    Spicer JA; Finlay GJ; Baguley BC; Velea L; Graves DE; Denny WA
    Anticancer Drug Des; 1999 Feb; 14(1):37-45. PubMed ID: 10363026
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis and biological evaluation of amino-substituted benzo[f]pyrido[4,3-b] and pyrido[3,4-b]quinoxalines: a new class of antineoplastic agents.
    Nguyen CH; Fan E; Riou JF; Bissery MC; Vrignaud P; Lavelle F; Bisagni E
    Anticancer Drug Des; 1995 Jun; 10(4):277-97. PubMed ID: 7786395
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Novel tetra-acridine derivatives as dual inhibitors of topoisomerase II and the human proteasome.
    Vispé S; Vandenberghe I; Robin M; Annereau JP; Créancier L; Pique V; Galy JP; Kruczynski A; Barret JM; Bailly C
    Biochem Pharmacol; 2007 Jun; 73(12):1863-72. PubMed ID: 17391647
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design, synthesis, and biological evaluation of a series of fluoroquinoanthroxazines with contrasting dual mechanisms of action against topoisomerase II and G-quadruplexes.
    Kim MY; Duan W; Gleason-Guzman M; Hurley LH
    J Med Chem; 2003 Feb; 46(4):571-83. PubMed ID: 12570378
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design and synthesis of modified quinolones as antitumoral acridones.
    Tabarrini O; Cecchetti V; Fravolini A; Nocentini G; Barzi A; Sabatini S; Miao H; Sissi C
    J Med Chem; 1999 Jun; 42(12):2136-44. PubMed ID: 10377219
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structure-activity relationships for acridine-substituted analogues of the mixed topoisomerase I/II inhibitor N-[2-(dimethylamino)ethyl]acridine-4-carboxamide.
    Spicer JA; Gamage SA; Atwell GJ; Finlay GJ; Baguley BC; Denny WA
    J Med Chem; 1997 Jun; 40(12):1919-29. PubMed ID: 9191970
    [TBL] [Abstract][Full Text] [Related]  

  • 15. 4-Hydroxymethyl-3-aminoacridine derivatives as a new family of anticancer agents.
    Charmantray F; Demeunynck M; Carrez D; Croisy A; Lansiaux A; Bailly C; Colson P
    J Med Chem; 2003 Mar; 46(6):967-77. PubMed ID: 12620073
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Design of new topoisomerase II inhibitors based upon a quinobenzoxazine self-assembly model.
    Zeng Q; Kwok Y; Kerwin SM; Mangold G; Hurley LH
    J Med Chem; 1998 Oct; 41(22):4273-8. PubMed ID: 9784102
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and biological activity of sulfonamide derivatives of epipodophyllotoxin.
    Guianvarc'h D; Duca M; Boukarim C; Kraus-Berthier L; Léonce S; Pierré A; Pfeiffer B; Renard P; Arimondo PB; Monneret C; Dauzonne D
    J Med Chem; 2004 Apr; 47(9):2365-74. PubMed ID: 15084135
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Methoxy- and methyl-, methoxy-5,6,11-trimethyl-6H-indolo [2,3-b]quinolinium derivatives as novel cytotoxic agents and DNA topoisomerase II inhibitors.
    Kaczmarek L; Peczyńska-Czoch W; Opolski A; Wietrzyk J; Marcinkowska E; Boratyński J; Osiadacz J
    Anticancer Res; 1998; 18(4C):3133-8. PubMed ID: 9713522
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis and antitumor properties of N-[2-(dimethylamino)ethyl]carboxamide derivatives of fused tetracyclic quinolines and quinoxalines: a new class of putative topoisomerase inhibitors.
    Deady LW; Kaye AJ; Finlay GJ; Baguley BC; Denny WA
    J Med Chem; 1997 Jun; 40(13):2040-6. PubMed ID: 9207945
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Antitumor agents. Part 230: C4'-esters of GL-331 as cytotoxic agents and DNA topoisomerase II inhibitors.
    Han S; Xiao Z; Bastow KF; Lee KH
    Bioorg Med Chem Lett; 2004 Jun; 14(11):2979-82. PubMed ID: 15125972
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.