255 related articles for article (PubMed ID: 9746908)
1. Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein.
Citron M; Eckman CB; Diehl TS; Corcoran C; Ostaszewski BL; Xia W; Levesque G; St George Hyslop P; Younkin SG; Selkoe DJ
Neurobiol Dis; 1998 Aug; 5(2):107-16. PubMed ID: 9746908
[TBL] [Abstract][Full Text] [Related]
2. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
Xia W; Zhang J; Ostaszewski BL; Kimberly WT; Seubert P; Koo EH; Shen J; Selkoe DJ
Biochemistry; 1998 Nov; 37(47):16465-71. PubMed ID: 9843412
[TBL] [Abstract][Full Text] [Related]
3. Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment.
Wiley JC; Hudson M; Kanning KC; Schecterson LC; Bothwell M
J Neurochem; 2005 Sep; 94(5):1189-201. PubMed ID: 15992373
[TBL] [Abstract][Full Text] [Related]
4. Decreased Abeta secretion by cells expressing familial Alzheimer's disease-linked mutant presenilin 1.
Shimojo M; Sahara N; Murayama M; Ichinose H; Takashima A
Neurosci Res; 2007 Mar; 57(3):446-53. PubMed ID: 17210196
[TBL] [Abstract][Full Text] [Related]
5. APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1.
Jankowsky JL; Slunt HH; Gonzales V; Jenkins NA; Copeland NG; Borchelt DR
Neurobiol Aging; 2004 Aug; 25(7):885-92. PubMed ID: 15212842
[TBL] [Abstract][Full Text] [Related]
6. FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.
Xia W; Ostaszewski BL; Kimberly WT; Rahmati T; Moore CL; Wolfe MS; Selkoe DJ
Neurobiol Dis; 2000 Dec; 7(6 Pt B):673-81. PubMed ID: 11114265
[TBL] [Abstract][Full Text] [Related]
7. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms.
Bentahir M; Nyabi O; Verhamme J; Tolia A; Horré K; Wiltfang J; Esselmann H; De Strooper B
J Neurochem; 2006 Feb; 96(3):732-42. PubMed ID: 16405513
[TBL] [Abstract][Full Text] [Related]
8. Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid beta-protein 42 in Chinese hamster ovary cells.
Qi Y; Morishima-Kawashima M; Sato T; Mitsumori R; Ihara Y
Biochemistry; 2003 Feb; 42(4):1042-52. PubMed ID: 12549925
[TBL] [Abstract][Full Text] [Related]
9. Down-regulation amyloid beta-protein 42 production by interfering with transcript of presenilin 1 gene with siRNA.
Luo HM; Deng H; Xiao F; Gao Q; Weng W; Zhang PF; Li XG
Acta Pharmacol Sin; 2004 Dec; 25(12):1613-8. PubMed ID: 15569405
[TBL] [Abstract][Full Text] [Related]
10. Baculoviruses expressing the human familial Alzheimer's disease presenilin 1 mutation lacking exon 9 increase levels of an amyloid beta-like protein in Sf9 cells.
Verdile G; Groth D; Mathews PM; St George-Hyslop P; Fraser PE; Ramabhadran TV; Kwok JB; Schofield PR; Carter T; Gandy S; Martins RN
Mol Psychiatry; 2004 Jun; 9(6):594-602. PubMed ID: 14993906
[TBL] [Abstract][Full Text] [Related]
11. Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.
Walker ES; Martinez M; Brunkan AL; Goate A
J Neurochem; 2005 Jan; 92(2):294-301. PubMed ID: 15663477
[TBL] [Abstract][Full Text] [Related]
12. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein.
De Strooper B; Saftig P; Craessaerts K; Vanderstichele H; Guhde G; Annaert W; Von Figura K; Van Leuven F
Nature; 1998 Jan; 391(6665):387-90. PubMed ID: 9450754
[TBL] [Abstract][Full Text] [Related]
13. Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue.
Podlisny MB; Citron M; Amarante P; Sherrington R; Xia W; Zhang J; Diehl T; Levesque G; Fraser P; Haass C; Koo EH; Seubert P; St George-Hyslop P; Teplow DB; Selkoe DJ
Neurobiol Dis; 1997; 3(4):325-37. PubMed ID: 9173929
[TBL] [Abstract][Full Text] [Related]
14. Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications for Alzheimer's disease.
Mohmmad Abdul H; Sultana R; Keller JN; St Clair DK; Markesbery WR; Butterfield DA
J Neurochem; 2006 Mar; 96(5):1322-35. PubMed ID: 16478525
[TBL] [Abstract][Full Text] [Related]
15. Increase in presenilin 1 (PS1) levels in senescence-accelerated mice (SAMP8) may indirectly impair memory by affecting amyloid precursor protein (APP) processing.
Kumar VB; Franko M; Banks WA; Kasinadhuni P; Farr SA; Vyas K; Choudhuri V; Morley JE
J Exp Biol; 2009 Feb; 212(Pt 4):494-8. PubMed ID: 19181896
[TBL] [Abstract][Full Text] [Related]
16. Presenilins are not required for A beta 42 production in the early secretory pathway.
Wilson CA; Doms RW; Zheng H; Lee VM
Nat Neurosci; 2002 Sep; 5(9):849-55. PubMed ID: 12145638
[TBL] [Abstract][Full Text] [Related]
17. Neuropathology of mice carrying mutant APP(swe) and/or PS1(M146L) transgenes: alterations in the p75(NTR) cholinergic basal forebrain septohippocampal pathway.
Jaffar S; Counts SE; Ma SY; Dadko E; Gordon MN; Morgan D; Mufson EJ
Exp Neurol; 2001 Aug; 170(2):227-43. PubMed ID: 11476589
[TBL] [Abstract][Full Text] [Related]
18. Alzheimer's disease. Molecular consequences of presenilin-1 mutation.
Gandy S; Naslund J; Nordstedt C
Nature; 2001 Jun; 411(6838):654-6. PubMed ID: 11395757
[TBL] [Abstract][Full Text] [Related]
19. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1.
Li YM; Xu M; Lai MT; Huang Q; Castro JL; DiMuzio-Mower J; Harrison T; Lellis C; Nadin A; Neduvelil JG; Register RB; Sardana MK; Shearman MS; Smith AL; Shi XP; Yin KC; Shafer JA; Gardell SJ
Nature; 2000 Jun; 405(6787):689-94. PubMed ID: 10864326
[TBL] [Abstract][Full Text] [Related]
20. The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice.
Wen PH; Hof PR; Chen X; Gluck K; Austin G; Younkin SG; Younkin LH; DeGasperi R; Gama Sosa MA; Robakis NK; Haroutunian V; Elder GA
Exp Neurol; 2004 Aug; 188(2):224-37. PubMed ID: 15246822
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
