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24. Distribution of mutations in human thymidylate synthase yielding resistance to 5-fluorodeoxyuridine. Kawate H; Landis DM; Loeb LA J Biol Chem; 2002 Sep; 277(39):36304-11. PubMed ID: 12147691 [TBL] [Abstract][Full Text] [Related]
25. The effect of 5-substitution in the pyrimidine ring of dUMP on the interaction with thymidylate synthase: molecular modeling and QSAR. Jarmuła A; Cieplak P; Krygowski TM; Rode W Bioorg Med Chem; 2007 Mar; 15(6):2346-58. PubMed ID: 17275316 [TBL] [Abstract][Full Text] [Related]
26. Properties of bacteriophage T4 thymidylate synthase following mutagenic changes in the active site and folate binding region. LaPat-Polasko L; Maley GF; Maley F Biochemistry; 1990 Oct; 29(41):9561-72. PubMed ID: 2271601 [TBL] [Abstract][Full Text] [Related]
27. Relationship of dUMP and free FdUMP pools to inhibition of thymidylate synthase by 5-fluorouracil. Berger SH; Hakala MT Mol Pharmacol; 1984 Mar; 25(2):303-9. PubMed ID: 6608049 [TBL] [Abstract][Full Text] [Related]
28. Multi-targeted antifolates aimed at avoiding drug resistance form covalent closed inhibitory complexes with human and Escherichia coli thymidylate synthases. Sayre PH; Finer-Moore JS; Fritz TA; Biermann D; Gates SB; MacKellar WC; Patel VF; Stroud RM J Mol Biol; 2001 Nov; 313(4):813-29. PubMed ID: 11697906 [TBL] [Abstract][Full Text] [Related]
29. Tryptophan 80 and leucine 143 are critical for the hydride transfer step of thymidylate synthase by controlling active site access. Fritz TA; Liu L; Finer-Moore JS; Stroud RM Biochemistry; 2002 Jun; 41(22):7021-9. PubMed ID: 12033935 [TBL] [Abstract][Full Text] [Related]
30. Mutation of asparagine 229 to aspartate in thymidylate synthase converts the enzyme to a deoxycytidylate methylase. Liu L; Santi DV Biochemistry; 1992 Jun; 31(22):5100-4. PubMed ID: 1606134 [TBL] [Abstract][Full Text] [Related]
31. Isolation of a covalent steady-state intermediate in glutamate 60 mutants of thymidylate synthase. Huang W; Santi DV J Biol Chem; 1994 Dec; 269(50):31327-9. PubMed ID: 7989294 [TBL] [Abstract][Full Text] [Related]
32. Effect of polyglutamylation of 5,10-methylenetetrahydrofolate on the binding of 5-fluoro-2'-deoxyuridylate to thymidylate synthase purified from a human colon adenocarcinoma xenograft. Radparvar S; Houghton PJ; Houghton JA Biochem Pharmacol; 1989 Jan; 38(2):335-42. PubMed ID: 2914018 [TBL] [Abstract][Full Text] [Related]
33. Substitution at residue 214 of human thymidylate synthase alters nucleotide binding and isomerization of ligand-protein complexes. Steadman DJ; Spencer HT; Dunlap RB; Berger SH Biochemistry; 1999 Apr; 38(17):5582-7. PubMed ID: 10220346 [TBL] [Abstract][Full Text] [Related]
34. A hydroxyl group at residue 216 is essential for catalysis by human thymidylate synthase. Williams AW; Dunlap RB; Berger SH Biochemistry; 1998 May; 37(20):7096-102. PubMed ID: 9585520 [TBL] [Abstract][Full Text] [Related]
35. Mechanisms of innate resistance to thymidylate synthase inhibition after 5-fluorouracil. Spears CP; Gustavsson BG; Berne M; Frösing R; Bernstein L; Hayes AA Cancer Res; 1988 Oct; 48(20):5894-900. PubMed ID: 3167844 [TBL] [Abstract][Full Text] [Related]
36. Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase. Finer-Moore JS; Liu L; Schafmeister CE; Birdsall DL; Mau T; Santi DV; Stroud RM Biochemistry; 1996 Apr; 35(16):5125-36. PubMed ID: 8611496 [TBL] [Abstract][Full Text] [Related]
37. Substitution of glutamine for glutamic acid-58 in Escherichia coli thymidylate synthase results in pronounced decreases in catalytic activity and ligand binding. Zapf JW; Weir MS; Emerick V; Villafranca JE; Dunlap RB Biochemistry; 1993 Sep; 32(36):9274-81. PubMed ID: 8103678 [TBL] [Abstract][Full Text] [Related]
38. Effects of subunit occupancy on partitioning of an intermediate in thymidylate synthase mutants. Variath P; Liu Y; Lee TT; Stroud RM; Santi DV Biochemistry; 2000 Mar; 39(10):2429-35. PubMed ID: 10704192 [TBL] [Abstract][Full Text] [Related]
39. Relative free energies of binding to thymidylate synthase of 2- and/or 4-thio and/or 5-fluoro analogues of dUMP. Jarmuła A; Cieplak P; Leś A; Rode W J Comput Aided Mol Des; 2003 Oct; 17(10):699-710. PubMed ID: 15068368 [TBL] [Abstract][Full Text] [Related]
40. The catalytic mechanism and structure of thymidylate synthase. Carreras CW; Santi DV Annu Rev Biochem; 1995; 64():721-62. PubMed ID: 7574499 [TBL] [Abstract][Full Text] [Related] [Previous] [Next] [New Search]