BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

149 related articles for article (PubMed ID: 9749368)

  • 1. Dihydrofolate reductase: a potential drug target in trypanosomes and leishmania.
    Zuccotto F; Martin AC; Laskowski RA; Thornton JM; Gilbert IH
    J Comput Aided Mol Des; 1998 May; 12(3):241-57. PubMed ID: 9749368
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Design, synthesis, and evaluation of inhibitors of trypanosomal and leishmanial dihydrofolate reductase.
    Chowdhury SF; Villamor VB; Guerrero RH; Leal I; Brun R; Croft SL; Goodman JM; Maes L; Ruiz-Perez LM; Pacanowska DG; Gilbert IH
    J Med Chem; 1999 Oct; 42(21):4300-12. PubMed ID: 10543874
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and testing of 5-benzyl-2,4-diaminopyrimidines as potential inhibitors of leishmanial and trypanosomal dihydrofolate reductase.
    Chowdhury SF; Guerrero RH; Brun R; Ruiz-Perez LM; Pacanowska DG; Gilbert IH
    J Enzyme Inhib Med Chem; 2002 Oct; 17(5):293-302. PubMed ID: 12683746
    [TBL] [Abstract][Full Text] [Related]  

  • 4. 2,4-Diaminopyrimidines as inhibitors of Leishmanial and Trypanosomal dihydrofolate reductase.
    Pez D; Leal I; Zuccotto F; Boussard C; Brun R; Croft SL; Yardley V; Ruiz Perez LM; Gonzalez Pacanowska D; Gilbert IH
    Bioorg Med Chem; 2003 Nov; 11(22):4693-711. PubMed ID: 14556785
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Homology modelling of the dihydrofolate reductase-thymidylate synthase bifunctional enzyme of Leishmania major, a potential target for rational drug design in leishmaniasis.
    McKie JH
    Drug Des Discov; 1994 Jun; 11(4):269-88. PubMed ID: 7727680
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The structure-based design and synthesis of selective inhibitors of Trypanosoma cruzi dihydrofolate reductase.
    Zuccotto F; Brun R; Gonzalez Pacanowska D; Ruiz Perez LM; Gilbert IH
    Bioorg Med Chem Lett; 1999 May; 9(10):1463-8. PubMed ID: 10360757
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibitors of dihydrofolate reductase in Leishmania and trypanosomes.
    Gilbert IH
    Biochim Biophys Acta; 2002 Jul; 1587(2-3):249-57. PubMed ID: 12084467
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase.
    Zuccotto F; Zvelebil M; Brun R; Chowdhury SF; Di Lucrezia R; Leal I; Maes L; Ruiz-Perez LM; Gonzalez Pacanowska D; Gilbert IH
    Eur J Med Chem; 2001 May; 36(5):395-405. PubMed ID: 11451529
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structures of dihydrofolate reductase-thymidylate synthase of Trypanosoma cruzi in the folate-free state and in complex with two antifolate drugs, trimetrexate and methotrexate.
    Senkovich O; Schormann N; Chattopadhyay D
    Acta Crystallogr D Biol Crystallogr; 2009 Jul; 65(Pt 7):704-16. PubMed ID: 19564691
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Trypanosomal dihydrofolate reductase reveals natural antifolate resistance.
    Vanichtanankul J; Taweechai S; Yuvaniyama J; Vilaivan T; Chitnumsub P; Kamchonwongpaisan S; Yuthavong Y
    ACS Chem Biol; 2011 Sep; 6(9):905-11. PubMed ID: 21650210
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Trypanosoma brucei dihydrofolate reductase-thymidylate synthase: gene isolation and expression and characterization of the enzyme.
    Gamarro F; Yu PL; Zhao J; Edman U; Greene PJ; Santi D
    Mol Biochem Parasitol; 1995 Jun; 72(1-2):11-22. PubMed ID: 8538681
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Interactions of 5-deazapteridine derivatives with Mycobacterium tuberculosis and with human dihydrofolate reductases.
    da Cunha EF; de Castro Ramalho T; Bicca de Alencastro R; Maia ER
    J Biomol Struct Dyn; 2004 Oct; 22(2):119-30. PubMed ID: 15317473
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure of and kinetic channelling in bifunctional dihydrofolate reductase-thymidylate synthase.
    Knighton DR; Kan CC; Howland E; Janson CA; Hostomska Z; Welsh KM; Matthews DA
    Nat Struct Biol; 1994 Mar; 1(3):186-94. PubMed ID: 7656037
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Design, synthesis and evaluation of 2,4-diaminoquinazolines as inhibitors of trypanosomal and leishmanial dihydrofolate reductase.
    Khabnadideh S; Pez D; Musso A; Brun R; Pérez LM; González-Pacanowska D; Gilbert IH
    Bioorg Med Chem; 2005 Apr; 13(7):2637-49. PubMed ID: 15755663
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Synthesis and characterization of potent inhibitors of Trypanosoma cruzi dihydrofolate reductase.
    Schormann N; Velu SE; Murugesan S; Senkovich O; Walker K; Chenna BC; Shinkre B; Desai A; Chattopadhyay D
    Bioorg Med Chem; 2010 Jun; 18(11):4056-66. PubMed ID: 20452776
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structure-based approach to pharmacophore identification, in silico screening, and three-dimensional quantitative structure-activity relationship studies for inhibitors of Trypanosoma cruzi dihydrofolate reductase function.
    Schormann N; Senkovich O; Walker K; Wright DL; Anderson AC; Rosowsky A; Ananthan S; Shinkre B; Velu S; Chattopadhyay D
    Proteins; 2008 Dec; 73(4):889-901. PubMed ID: 18536013
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Homology modeling of T. cruzi and L. major NADH-dependent fumarate reductases: ligand docking, molecular dynamics validation, and insights on their binding modes.
    Merlino A; Vieites M; Gambino D; Coitiño EL
    J Mol Graph Model; 2014 Mar; 48():47-59. PubMed ID: 24370672
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Sequence variation in the dihydrofolate reductase-thymidylate synthase (DHFR-TS) and trypanothione reductase (TR) genes of Trypanosoma cruzi.
    Machado CA; Ayala FJ
    Mol Biochem Parasitol; 2002 Apr; 121(1):33-47. PubMed ID: 11985861
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Sesquiterpene Lactones with Dual Inhibitory Activity against the
    Possart K; Herrmann FC; Jose J; Costi MP; Schmidt TJ
    Molecules; 2021 Dec; 27(1):. PubMed ID: 35011381
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate.
    Dawson A; Gibellini F; Sienkiewicz N; Tulloch LB; Fyfe PK; McLuskey K; Fairlamb AH; Hunter WN
    Mol Microbiol; 2006 Sep; 61(6):1457-68. PubMed ID: 16968221
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.