BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

239 related articles for article (PubMed ID: 9765344)

  • 1. Effects of ketoconazole on the intestinal metabolism, transport and oral bioavailability of K02, a novel vinylsulfone peptidomimetic cysteine protease inhibitor and a P450 3A, P-glycoprotein dual substrate, in male Sprague-Dawley rats.
    Zhang Y; Hsieh Y; Izumi T; Lin ET; Benet LZ
    J Pharmacol Exp Ther; 1998 Oct; 287(1):246-52. PubMed ID: 9765344
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Overlapping substrate specificities of cytochrome P450 3A and P-glycoprotein for a novel cysteine protease inhibitor.
    Zhang Y; Guo X; Lin ET; Benet LZ
    Drug Metab Dispos; 1998 Apr; 26(4):360-6. PubMed ID: 9531525
    [TBL] [Abstract][Full Text] [Related]  

  • 3. In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: studies using the rat single-pass intestinal perfusion model.
    Cummins CL; Salphati L; Reid MJ; Benet LZ
    J Pharmacol Exp Ther; 2003 Apr; 305(1):306-14. PubMed ID: 12649383
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Differentiation of intestinal and hepatic cytochrome P450 3A activity with use of midazolam as an in vivo probe: effect of ketoconazole.
    Tsunoda SM; Velez RL; von Moltke LL; Greenblatt DJ
    Clin Pharmacol Ther; 1999 Nov; 66(5):461-71. PubMed ID: 10579473
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Pharmacokinetics and interactions of a novel antagonist of chemokine receptor 5 (CCR5) with ritonavir in rats and monkeys: role of CYP3A and P-glycoprotein.
    Kumar S; Kwei GY; Poon GK; Iliff SA; Wang Y; Chen Q; Franklin RB; Didolkar V; Wang RW; Yamazaki M; Chiu SH; Lin JH; Pearson PG; Baillie TA
    J Pharmacol Exp Ther; 2003 Mar; 304(3):1161-71. PubMed ID: 12604693
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The effects of inhibiting cytochrome P450 3A, p-glycoprotein, and gastric acid secretion on the oral bioavailability of methadone in dogs.
    Kukanich B; Lascelles BD; Aman AM; Mealey KL; Papich MG
    J Vet Pharmacol Ther; 2005 Oct; 28(5):461-6. PubMed ID: 16207309
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Effect of dexamethasone on the intestinal first-pass metabolism of indinavir in rats: evidence of cytochrome P-450 3A [correction of P-450 A] and p-glycoprotein induction .
    Lin JH; Chiba M; Chen IW; Nishime JA; deLuna FA; Yamazaki M; Lin YJ
    Drug Metab Dispos; 1999 Oct; 27(10):1187-93. PubMed ID: 10497146
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Application of semisimultaneous midazolam administration for hepatic and intestinal cytochrome P450 3A phenotyping.
    Lee JI; Chaves-Gnecco D; Amico JA; Kroboth PD; Wilson JW; Frye RF
    Clin Pharmacol Ther; 2002 Dec; 72(6):718-28. PubMed ID: 12496753
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Induction of P-glycoprotein and cytochrome P450 3A by HIV protease inhibitors.
    Huang L; Wring SA; Woolley JL; Brouwer KR; Serabjit-Singh C; Polli JW
    Drug Metab Dispos; 2001 May; 29(5):754-60. PubMed ID: 11302944
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Development of an in vivo preclinical screen model to estimate absorption and first-pass hepatic extraction of xenobiotics. II. Use of ketoconazole to identify P-glycoprotein/CYP3A-limited bioavailability in the monkey.
    Ward KW; Stelman GJ; Morgan JA; Zeigler KS; Azzarano LM; Kehler JR; McSurdy-Freed JE; Proksch JW; Smith BR
    Drug Metab Dispos; 2004 Feb; 32(2):172-7. PubMed ID: 14744938
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Sirolimus oral absorption in rats is increased by ketoconazole but is not affected by D-alpha-tocopheryl poly(ethylene glycol 1000) succinate.
    Wacher VJ; Silverman JA; Wong S; Tran-Tau P; Chan AO; Chai A; Yu XQ; O'Mahony D; Ramtoola Z
    J Pharmacol Exp Ther; 2002 Oct; 303(1):308-13. PubMed ID: 12235265
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The effect of age, sex, and rifampin administration on intestinal and hepatic cytochrome P450 3A activity.
    Gorski JC; Vannaprasaht S; Hamman MA; Ambrosius WT; Bruce MA; Haehner-Daniels B; Hall SD
    Clin Pharmacol Ther; 2003 Sep; 74(3):275-87. PubMed ID: 12966371
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Pharmacokinetic interaction of cytochrome P450 3A-related compounds with rhodamine 123, a P-glycoprotein substrate, in rats pretreated with dexamethasone.
    Yumoto R; Murakami T; Sanemasa M; Nasu R; Nagai J; Takano M
    Drug Metab Dispos; 2001 Feb; 29(2):145-51. PubMed ID: 11159804
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Characterization of P-glycoprotein mediated transport of K02, a novel vinylsulfone peptidomimetic cysteine protease inhibitor, across MDR1-MDCK and Caco-2 cell monolayers.
    Zhang Y; Benet LZ
    Pharm Res; 1998 Oct; 15(10):1520-4. PubMed ID: 9794492
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Decrease in oral bioavailability of ciclosporin by intravenous pulse of methylprednisolone succinate in rats.
    Konishi H; Sumi M; Shibata N; Takada K; Minouchi T; Yamaji A
    J Pharm Pharmacol; 2004 Oct; 56(10):1259-66. PubMed ID: 15482640
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis.
    Kharasch ED; Walker A; Hoffer C; Sheffels P
    Clin Pharmacol Ther; 2004 Nov; 76(5):452-66. PubMed ID: 15536460
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Determination of the enzyme(s) involved in the metabolism of amiodarone in liver and intestine of rat: the contribution of cytochrome P450 3A isoforms.
    Shayeganpour A; El-Kadi AO; Brocks DR
    Drug Metab Dispos; 2006 Jan; 34(1):43-50. PubMed ID: 16204463
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics.
    Wacher VJ; Silverman JA; Zhang Y; Benet LZ
    J Pharm Sci; 1998 Nov; 87(11):1322-30. PubMed ID: 9811484
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Effect of various cytochrome P450 3A and P-glycoprotein modulators on the biliary clearance of bromosulphaphthalein in male wistar rats.
    Machavaram KK; Gundu J; Yamsani MR
    Pharmazie; 2004 Dec; 59(12):957-60. PubMed ID: 15638086
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Inhibitory effect of docosahexaenoic acid (DHA) on the intestinal metabolism of midazolam: in vitro and in vivo studies in rats.
    Hirunpanich V; Murakoso K; Sato H
    Int J Pharm; 2008 Mar; 351(1-2):133-43. PubMed ID: 18082981
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.