These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

170 related articles for article (PubMed ID: 9776318)

  • 1. Structural and functional comparison of agents interfering with dihydroorotate, succinate and NADH oxidation of rat liver mitochondria.
    Jöckel J; Wendt B; Löffler M
    Biochem Pharmacol; 1998 Oct; 56(8):1053-60. PubMed ID: 9776318
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Species-related inhibition of human and rat dihydroorotate dehydrogenase by immunosuppressive isoxazol and cinchoninic acid derivatives.
    Knecht W; Löffler M
    Biochem Pharmacol; 1998 Nov; 56(9):1259-64. PubMed ID: 9802339
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Catalytic enzyme histochemistry and biochemical analysis of dihydroorotate dehydrogenase/oxidase and succinate dehydrogenase in mammalian tissues, cells and mitochondria.
    Löffler M; Becker C; Wegerle E; Schuster G
    Histochem Cell Biol; 1996 Feb; 105(2):119-28. PubMed ID: 8852433
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid.
    Knecht W; Henseling J; Löffler M
    Chem Biol Interact; 2000 Jan; 124(1):61-76. PubMed ID: 10658902
    [TBL] [Abstract][Full Text] [Related]  

  • 5. In vitro and in Vivo inhibition of immunoglobulin secretion by the immunosuppressive compound HR325 is reversed by exogenous uridine.
    Thomson TA; Spinella-Jaegle S; Francesconi E; Meakin C; Millet S; Flao KL; Hidden H; Ruuth E
    Scand J Immunol; 2002 Jul; 56(1):35-42. PubMed ID: 12100469
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Inhibition of dihydroorotate dehydrogenase by the immunosuppressive agent leflunomide.
    Greene S; Watanabe K; Braatz-Trulson J; Lou L
    Biochem Pharmacol; 1995 Sep; 50(6):861-7. PubMed ID: 7575649
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Recombinant expression of N-terminal truncated mutants of the membrane bound mouse, rat and human flavoenzyme dihydroorotate dehydrogenase. A versatile tool to rate inhibitor effects?
    Ullrich A; Knecht W; Fries M; Löffler M
    Eur J Biochem; 2001 Mar; 268(6):1861-8. PubMed ID: 11248707
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Dihydroorotate dehydrogenase is a high affinity binding protein for A77 1726 and mediator of a range of biological effects of the immunomodulatory compound.
    Williamson RA; Yea CM; Robson PA; Curnock AP; Gadher S; Hambleton AB; Woodward K; Bruneau JM; Hambleton P; Moss D; Thomson TA; Spinella-Jaegle S; Morand P; Courtin O; Sautés C; Westwood R; Hercend T; Kuo EA; Ruuth E
    J Biol Chem; 1995 Sep; 270(38):22467-72. PubMed ID: 7673235
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Redoxal as a new lead structure for dihydroorotate dehydrogenase inhibitors: a kinetic study of the inhibition mechanism.
    Knecht W; Löffler M
    FEBS Lett; 2000 Feb; 467(1):27-30. PubMed ID: 10664450
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Multiple inhibitor analysis of the brequinar and leflunomide binding sites on human dihydroorotate dehydrogenase.
    McLean JE; Neidhardt EA; Grossman TH; Hedstrom L
    Biochemistry; 2001 Feb; 40(7):2194-200. PubMed ID: 11329288
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Functional expression of a fragment of human dihydroorotate dehydrogenase by means of the baculovirus expression vector system, and kinetic investigation of the purified recombinant enzyme.
    Knecht W; Bergjohann U; Gonski S; Kirschbaum B; Löffler M
    Eur J Biochem; 1996 Aug; 240(1):292-301. PubMed ID: 8925840
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Rat dihydroorotate dehydrogenase: isolation of the recombinant enzyme from mitochondria of insect cells.
    Knecht W; Altekruse D; Rotgeri A; Gonski S; Löffler M
    Protein Expr Purif; 1997 Jun; 10(1):89-99. PubMed ID: 9179295
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Inhibition of dihydroorotate dehydrogenase activity by brequinar sodium.
    Chen SF; Perrella FW; Behrens DL; Papp LM
    Cancer Res; 1992 Jul; 52(13):3521-7. PubMed ID: 1617622
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Inhibition of stimulated Jurkat cell adenosine 3',5'-cyclic monophosphate synthesis by the immunomodulatory compound HR325.
    Curnock AP; Thomson TA; Westwood R; Kuo EA; Williamson RA; Yea CM; Ruuthb E
    Biochem Pharmacol; 2001 Jan; 61(2):227-35. PubMed ID: 11163337
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase.
    Davis JP; Cain GA; Pitts WJ; Magolda RL; Copeland RA
    Biochemistry; 1996 Jan; 35(4):1270-3. PubMed ID: 8573583
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Inhibition of canine distemper virus replication by blocking pyrimidine nucleotide synthesis with A77 1726, the active metabolite of the anti-inflammatory drug leflunomide.
    Li Y; Yi L; Cheng S; Wang Y; Wang J; Sun J; Zhang Q; Xu X
    J Gen Virol; 2021 Mar; 102(3):. PubMed ID: 33416466
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Differential susceptibility of dihydroorotate dehydrogenase/oxidase to Brequinar Sodium (NSC 368 390) in vitro.
    Lakaschus G; Löffler M
    Biochem Pharmacol; 1992 Mar; 43(5):1025-30. PubMed ID: 1313236
    [TBL] [Abstract][Full Text] [Related]  

  • 18. New inhibitors of dihydroorotate dehydrogenase (DHODH) based on the 4-hydroxy-1,2,5-oxadiazol-3-yl (hydroxyfurazanyl) scaffold.
    Lolli ML; Giorgis M; Tosco P; Foti A; Fruttero R; Gasco A
    Eur J Med Chem; 2012 Mar; 49():102-9. PubMed ID: 22245049
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Synthesis, structure-activity relationships, and pharmacokinetic properties of dihydroorotate dehydrogenase inhibitors: 2-cyano-3-cyclopropyl-3-hydroxy-N-[3'-methyl-4'-(trifluoromethyl)phenyl ] propenamide and related compounds.
    Kuo EA; Hambleton PT; Kay DP; Evans PL; Matharu SS; Little E; McDowall N; Jones CB; Hedgecock CJ; Yea CM; Chan AW; Hairsine PW; Ager IR; Tully WR; Williamson RA; Westwood R
    J Med Chem; 1996 Nov; 39(23):4608-21. PubMed ID: 8917650
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Expression, purification, and characterization of histidine-tagged rat and human flavoenzyme dihydroorotate dehydrogenase.
    Bader B; Knecht W; Fries M; Löffler M
    Protein Expr Purif; 1998 Aug; 13(3):414-22. PubMed ID: 9693067
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.