These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
132 related articles for article (PubMed ID: 9784101)
1. Quantitative structure-activity relationships of 2, 4-diamino-5-(2-X-benzyl)pyrimidines versus bacterial and avian dihydrofolate reductase. Selassie CD; Gan WX; Kallander LS; Klein TE J Med Chem; 1998 Oct; 41(22):4261-72. PubMed ID: 9784101 [TBL] [Abstract][Full Text] [Related]
2. On the optimization of hydrophobic and hydrophilic substituent interactions of 2,4-diamino-5-(substituted-benzyl)pyrimidines with dihydrofolate reductase. Selassie CD; Li RL; Poe M; Hansch C J Med Chem; 1991 Jan; 34(1):46-54. PubMed ID: 1899453 [TBL] [Abstract][Full Text] [Related]
3. Crystallography, quantitative structure-activity relationships, and molecular graphics in a comparative analysis of the inhibition of dihydrofolate reductase from chicken liver and Lactobacillus casei by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazine s. Hansch C; Hathaway BA; Guo ZR; Selassie CD; Dietrich SW; Blaney JM; Langridge R; Volz KW; Kaufman BT J Med Chem; 1984 Feb; 27(2):129-43. PubMed ID: 6420569 [TBL] [Abstract][Full Text] [Related]
4. On the structure selectivity problem in drug design. A comparative study of benzylpyrimidine inhibition of vertebrate and bacterial dihydrofolate reductase via molecular graphics and quantitative structure-activity relationships. Selassie CD; Fang ZX; Li RL; Hansch C; Debnath G; Klein TE; Langridge R; Kaufman BT J Med Chem; 1989 Aug; 32(8):1895-905. PubMed ID: 2502631 [TBL] [Abstract][Full Text] [Related]
5. Comparison of the inhibition of Escherichia coli and Lactobacillus casei dihydrofolate reductase by 2,4-diamino-5-(substituted-benzyl)pyrimidines: quantitative structure-activity relationships, X-ray crystallography, and computer graphics in structure-activity analysis. Hansch C; Li R; Blaney JM; Langridge R J Med Chem; 1982 Jul; 25(7):777-84. PubMed ID: 6809941 [TBL] [Abstract][Full Text] [Related]
6. Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis. Wyatt EE; Galloway WR; Thomas GL; Welch M; Loiseleur O; Plowright AT; Spring DR Chem Commun (Camb); 2008 Oct; (40):4962-4. PubMed ID: 18931753 [TBL] [Abstract][Full Text] [Related]
7. Selective Pneumocystis carinii dihydrofolate reductase inhibitors: design, synthesis, and biological evaluation of new 2,4-diamino-5-substituted-furo[2,3-d]pyrimidines. Gangjee A; Guo X; Queener SF; Cody V; Galitsky N; Luft JR; Pangborn W J Med Chem; 1998 Apr; 41(8):1263-71. PubMed ID: 9548816 [TBL] [Abstract][Full Text] [Related]
8. Novel dihydrofolate reductase inhibitors. Structure-based versus diversity-based library design and high-throughput synthesis and screening. Wyss PC; Gerber P; Hartman PG; Hubschwerlen C; Locher H; Marty HP; Stahl M J Med Chem; 2003 Jun; 46(12):2304-12. PubMed ID: 12773035 [TBL] [Abstract][Full Text] [Related]
9. The charge state of substrates and inhibitors when bound to Lactobacillus casei dihydrofolate reductase [proceedings]. Hood K; Roberts GC Biochem Soc Trans; 1977; 5(3):771-2. PubMed ID: 20381 [No Abstract] [Full Text] [Related]
10. Inhibition of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductases by 2,4-diamino-5-[2-methoxy-5-(omega-carboxyalkyloxy)benzyl]pyrimidines: marked improvement in potency relative to trimethoprim and species selectivity relative to piritrexim. Rosowsky A; Forsch RA; Queener SF J Med Chem; 2002 Jan; 45(1):233-41. PubMed ID: 11754594 [TBL] [Abstract][Full Text] [Related]
11. New 2,4-diamino-5-(2',5'-substituted benzyl)pyrimidines as potential drugs against opportunistic infections of AIDS and other immune disorders. Synthesis and species-dependent antifolate activity. Rosowsky A; Forsch RA; Sibley CH; Inderlied CB; Queener SF J Med Chem; 2004 Mar; 47(6):1475-86. PubMed ID: 14998335 [TBL] [Abstract][Full Text] [Related]
12. Structure-based design and synthesis of lipophilic 2,4-diamino-6-substituted quinazolines and their evaluation as inhibitors of dihydrofolate reductases and potential antitumor agents. Gangjee A; Vidwans AP; Vasudevan A; Queener SF; Kisliuk RL; Cody V; Li R; Galitsky N; Luft JR; Pangborn W J Med Chem; 1998 Aug; 41(18):3426-34. PubMed ID: 9719595 [TBL] [Abstract][Full Text] [Related]
13. Design, synthesis, and X-ray crystal structure of a potent dual inhibitor of thymidylate synthase and dihydrofolate reductase as an antitumor agent. Gangjee A; Yu J; McGuire JJ; Cody V; Galitsky N; Kisliuk RL; Queener SF J Med Chem; 2000 Oct; 43(21):3837-51. PubMed ID: 11052789 [TBL] [Abstract][Full Text] [Related]
14. Synthesis and biological activity of substituted 2,4-diaminopyrimidines that inhibit Bacillus anthracis. Nammalwar B; Bunce RA; Berlin KD; Bourne CR; Bourne PC; Barrow EW; Barrow WW Eur J Med Chem; 2012 Aug; 54():387-96. PubMed ID: 22703705 [TBL] [Abstract][Full Text] [Related]
15. Nonclassical 2,4-diamino-5-aryl-6-ethylpyrimidine antifolates: activity as inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents. Robson C; Meek MA; Grunwaldt JD; Lambert PA; Queener SF; Schmidt D; Griffin RJ J Med Chem; 1997 Sep; 40(19):3040-8. PubMed ID: 9301666 [TBL] [Abstract][Full Text] [Related]
17. Reduction of oxidised folates by dihydrofolate reductase from methotrexate-resistant Lactobacillus casei. McIntyre LJ; Harding NG Biochim Biophys Acta; 1977 Jun; 482(2):261-71. PubMed ID: 18181 [TBL] [Abstract][Full Text] [Related]
18. Targeting species specific amino acid residues: Design, synthesis and biological evaluation of 6-substituted pyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors and potential anti-opportunistic infection agents. Shah K; Lin X; Queener SF; Cody V; Pace J; Gangjee A Bioorg Med Chem; 2018 May; 26(9):2640-2650. PubMed ID: 29691153 [TBL] [Abstract][Full Text] [Related]
19. Synthesis and biological activities of tricyclic conformationally restricted tetrahydropyrido annulated furo[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases. Gangjee A; Elzein E; Queener SF; McGuire JJ J Med Chem; 1998 Apr; 41(9):1409-16. PubMed ID: 9554874 [TBL] [Abstract][Full Text] [Related]
20. Further studies on 2,4-diamino-5-(2',5'-disubstituted benzyl)pyrimidines as potent and selective inhibitors of dihydrofolate reductases from three major opportunistic pathogens of AIDS. Rosowsky A; Forsch RA; Queener SF J Med Chem; 2003 Apr; 46(9):1726-36. PubMed ID: 12699390 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]