113 related articles for article (PubMed ID: 9790669)
1. A 1.4 A crystal structure for the hypoxanthine phosphoribosyltransferase of Trypanosoma cruzi.
Focia PJ; Craig SP; Nieves-Alicea R; Fletterick RJ; Eakin AE
Biochemistry; 1998 Oct; 37(43):15066-75. PubMed ID: 9790669
[TBL] [Abstract][Full Text] [Related]
2. Approaching the transition state in the crystal structure of a phosphoribosyltransferase.
Focia PJ; Craig SP; Eakin AE
Biochemistry; 1998 Dec; 37(49):17120-7. PubMed ID: 9860824
[TBL] [Abstract][Full Text] [Related]
3. Crystal structure of the dimeric phosphoenolpyruvate carboxykinase (PEPCK) from Trypanosoma cruzi at 2 A resolution.
Trapani S; Linss J; Goldenberg S; Fischer H; Craievich AF; Oliva G
J Mol Biol; 2001 Nov; 313(5):1059-72. PubMed ID: 11700062
[TBL] [Abstract][Full Text] [Related]
4. Interactions at the dimer interface influence the relative efficiencies for purine nucleotide synthesis and pyrophosphorolysis in a phosphoribosyltransferase.
Canyuk B; Medrano FJ; Wenck MA; Focia PJ; Eakin AE; Craig SP
J Mol Biol; 2004 Jan; 335(4):905-21. PubMed ID: 14698288
[TBL] [Abstract][Full Text] [Related]
5. Saturation mutagenesis, complement selection, and steady-state kinetic studies illuminate the roles of invariant residues in active site loop I of the hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi.
Butterworth AC; Medrano FJ; Eakin AE; Craig SP
Biochim Biophys Acta; 2004 Jun; 1699(1-2):87-94. PubMed ID: 15158715
[TBL] [Abstract][Full Text] [Related]
6. The structure of Trypanosoma cruzi trypanothione reductase in the oxidized and NADPH reduced state.
Lantwin CB; Schlichting I; Kabsch W; Pai EF; Krauth-Siegel RL
Proteins; 1994 Feb; 18(2):161-73. PubMed ID: 8159665
[TBL] [Abstract][Full Text] [Related]
7. A flexible loop at the dimer interface is a part of the active site of the adjacent monomer of Escherichia coli orotate phosphoribosyltransferase.
Henriksen A; Aghajari N; Jensen KF; Gajhede M
Biochemistry; 1996 Mar; 35(12):3803-9. PubMed ID: 8620002
[TBL] [Abstract][Full Text] [Related]
8. The crystal structure of free human hypoxanthine-guanine phosphoribosyltransferase reveals extensive conformational plasticity throughout the catalytic cycle.
Keough DT; Brereton IM; de Jersey J; Guddat LW
J Mol Biol; 2005 Aug; 351(1):170-81. PubMed ID: 15990111
[TBL] [Abstract][Full Text] [Related]
9. Structures of dihydrofolate reductase-thymidylate synthase of Trypanosoma cruzi in the folate-free state and in complex with two antifolate drugs, trimetrexate and methotrexate.
Senkovich O; Schormann N; Chattopadhyay D
Acta Crystallogr D Biol Crystallogr; 2009 Jul; 65(Pt 7):704-16. PubMed ID: 19564691
[TBL] [Abstract][Full Text] [Related]
10. Analysis of 6-(2,2-Dichloroacetamido)chrysene interaction with the hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi.
Medrano FJ; Wenck MA; Engel JC; Craig SP
J Med Chem; 2003 Jun; 46(12):2548-50. PubMed ID: 12773058
[TBL] [Abstract][Full Text] [Related]
11. The role for an invariant aspartic acid in hypoxanthine phosphoribosyltransferases is examined using saturation mutagenesis, functional analysis, and X-ray crystallography.
Canyuk B; Focia PJ; Eakin AE
Biochemistry; 2001 Mar; 40(9):2754-65. PubMed ID: 11258886
[TBL] [Abstract][Full Text] [Related]
12. Hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi as a target for structure-based inhibitor design: crystallization and inhibition studies with purine analogs.
Eakin AE; Guerra A; Focia PJ; Torres-Martinez J; Craig SP
Antimicrob Agents Chemother; 1997 Aug; 41(8):1686-92. PubMed ID: 9257742
[TBL] [Abstract][Full Text] [Related]
13. Crystal structure of the tryparedoxin peroxidase from the human parasite Trypanosoma cruzi.
PiƱeyro MD; Pizarro JC; Lema F; Pritsch O; Cayota A; Bentley GA; Robello C
J Struct Biol; 2005 Apr; 150(1):11-22. PubMed ID: 15797726
[TBL] [Abstract][Full Text] [Related]
14. Crystal structure of Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyl transferase L160I mutant--insights into inhibitor design.
Chen Q; You D; Liang Y; Su X; Gu X; Luo M; Zheng X
FEBS J; 2007 Sep; 274(17):4408-15. PubMed ID: 17662107
[TBL] [Abstract][Full Text] [Related]
15. Crystal structure of the Trypanosoma cruzi trypanothione reductase.mepacrine complex.
Jacoby EM; Schlichting I; Lantwin CB; Kabsch W; Krauth-Siegel RL
Proteins; 1996 Jan; 24(1):73-80. PubMed ID: 8628734
[TBL] [Abstract][Full Text] [Related]
16. Limited proteolysis of a trypanosomal hypoxanthine phosphoribosyltransferase yields crystals that diffract X-rays to near atomic resolution.
Nieves-Alicea R; Focia PJ; Craig SP; Eakin AE
Biochim Biophys Acta; 1998 Nov; 1388(2):500-5. PubMed ID: 9858784
[TBL] [Abstract][Full Text] [Related]
17. Investigation of the functional role of active site loop II in a hypoxanthine phosphoribosyltransferase.
Lee CC; Medrano FJ; Craig SP; Eakin AE
Biochim Biophys Acta; 2001 Jul; 1537(1):63-70. PubMed ID: 11476964
[TBL] [Abstract][Full Text] [Related]
18. Efficient identification of inhibitors targeting the closed active site conformation of the HPRT from Trypanosoma cruzi.
Freymann DM; Wenck MA; Engel JC; Feng J; Focia PJ; Eakin AE; Craig SP
Chem Biol; 2000 Dec; 7(12):957-68. PubMed ID: 11137818
[TBL] [Abstract][Full Text] [Related]
19. Alternative IMP binding in feedback inhibition of hypoxanthine-guanine phosphoribosyltransferase from Thermoanaerobacter tengcongensis.
Chen Q; Liang Y; Su X; Gu X; Zheng X; Luo M
J Mol Biol; 2005 May; 348(5):1199-210. PubMed ID: 15854655
[TBL] [Abstract][Full Text] [Related]
20. Molecular characterization and overexpression of the hypoxanthine-guanine phosphoribosyltransferase gene from Trypanosoma cruzi.
Allen TE; Ullman B
Mol Biochem Parasitol; 1994 Jun; 65(2):233-45. PubMed ID: 7969265
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]