BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

251 related articles for article (PubMed ID: 9797227)

  • 1. The Epstein-Barr virus thymidine kinase does not phosphorylate ganciclovir or acyclovir and demonstrates a narrow substrate specificity compared to the herpes simplex virus type 1 thymidine kinase.
    Gustafson EA; Chillemi AC; Sage DR; Fingeroth JD
    Antimicrob Agents Chemother; 1998 Nov; 42(11):2923-31. PubMed ID: 9797227
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Human herpesvirus 8 open reading frame 21 is a thymidine and thymidylate kinase of narrow substrate specificity that efficiently phosphorylates zidovudine but not ganciclovir.
    Gustafson EA; Schinazi RF; Fingeroth JD
    J Virol; 2000 Jan; 74(2):684-92. PubMed ID: 10623730
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The Epstein-Barr virus (EBV)-encoded protein kinase, EBV-PK, but not the thymidine kinase (EBV-TK), is required for ganciclovir and acyclovir inhibition of lytic viral production.
    Meng Q; Hagemeier SR; Fingeroth JD; Gershburg E; Pagano JS; Kenney SC
    J Virol; 2010 May; 84(9):4534-42. PubMed ID: 20181711
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Characterization of herpes simplex virus type 1 thymidine kinase mutants engineered for improved ganciclovir or acyclovir activity.
    Kokoris MS; Black ME
    Protein Sci; 2002 Sep; 11(9):2267-72. PubMed ID: 12192082
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Selective abolishment of pyrimidine nucleoside kinase activity of herpes simplex virus type 1 thymidine kinase by mutation of alanine-167 to tyrosine.
    Degrève B; Esnouf R; De Clercq E; Balzarini J
    Mol Pharmacol; 2000 Dec; 58(6):1326-32. PubMed ID: 11093770
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A new acycloguanosine-specific supermutant of herpes simplex virus type 1 thymidine kinase suitable for PET imaging and suicide gene therapy for potential use in patients treated with pyrimidine-based cytotoxic drugs.
    Likar Y; Dobrenkov K; Olszewska M; Vider E; Shenker L; Cai S; Pillarsetty N; Hricak H; Ponomarev V
    J Nucl Med; 2008 May; 49(5):713-20. PubMed ID: 18413388
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Intracellular uptake of thymidine and antiherpetic drugs for thymidine kinase-deficient mutants of herpes simplex virus type 1.
    Bae PK; Kim JH; Kim HS; Chung IK; Paik SG; Lee CK
    Antiviral Res; 2006 Jul; 70(3):93-104. PubMed ID: 16546268
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Substrate specificity and molecular modelling of the feline herpesvirus-1 thymidine kinase.
    Hussein IT; Miguel RN; Tiley LS; Field HJ
    Arch Virol; 2008; 153(3):495-505. PubMed ID: 18196203
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The A167Y mutation converts the herpes simplex virus type 1 thymidine kinase into a guanosine analogue kinase.
    Balzarini J; Liekens S; Esnouf R; De Clercq E
    Biochemistry; 2002 May; 41(20):6517-24. PubMed ID: 12009916
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Conservative mutations of glutamine-125 in herpes simplex virus type 1 thymidine kinase result in a ganciclovir kinase with minimal deoxypyrimidine kinase activities.
    Hinds TA; Compadre C; Hurlburt BK; Drake RR
    Biochemistry; 2000 Apr; 39(14):4105-11. PubMed ID: 10747801
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mutation of Gln125 to Asn selectively abolishes the thymidylate kinase activity of herpes simplex virus type 1 thymidine kinase.
    Degrève B; Esnouf R; De Clercq E; Balzarini J
    Mol Pharmacol; 2001 Feb; 59(2):285-93. PubMed ID: 11160865
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Importance of C-terminus of herpes simplex virus type 1 thymidine kinase for maintaining thymidine kinase and acyclovir-phosphorylation activities.
    Saijo M; Suzutani T; Niikura M; Morikawa S; Kurane I
    J Med Virol; 2002 Mar; 66(3):388-93. PubMed ID: 11793392
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides.
    Focher F; Lossani A; Verri A; Spadari S; Maioli A; Gambino JJ; Wright GE; Eberle R; Black DH; Medveczky P; Medveczky M; Shugar D
    Antimicrob Agents Chemother; 2007 Jun; 51(6):2028-34. PubMed ID: 17438061
    [TBL] [Abstract][Full Text] [Related]  

  • 14. A truncated herpes simplex virus thymidine kinase phosphorylates thymidine and nucleoside analogs and does not cause sterility in transgenic mice.
    Salomon B; Maury S; Loubière L; Caruso M; Onclercq R; Klatzmann D
    Mol Cell Biol; 1995 Oct; 15(10):5322-8. PubMed ID: 7565681
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Induction of Epstein-Barr virus kinases to sensitize tumor cells to nucleoside analogues.
    Moore SM; Cannon JS; Tanhehco YC; Hamzeh FM; Ambinder RF
    Antimicrob Agents Chemother; 2001 Jul; 45(7):2082-91. PubMed ID: 11408227
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mutation of herpesvirus thymidine kinase to generate ganciclovir-specific kinases for use in cancer gene therapies.
    Mercer KE; Ahn CE; Coke A; Compadre CM; Drake RR
    Protein Eng; 2002 Nov; 15(11):903-11. PubMed ID: 12538910
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Interaction of the recombinant herpes simplex virus type 1 thymidine kinase with thymidine and aciclovir: a kinetic study.
    Kussmann-Gerber S; Wurth C; Scapozza L; Pilger BD; Pliska V; Folkers G
    Nucleosides Nucleotides; 1999 Mar; 18(3):311-30. PubMed ID: 10358938
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A designed equine herpes thymidine kinase (EHV4 TK) variant improves ganciclovir-induced cell-killing.
    McSorley T; Ort S; Monnerjahn C; Konrad M
    Biochem Pharmacol; 2014 Feb; 87(3):435-44. PubMed ID: 24316433
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Differential ganciclovir-mediated cell killing by glutamine 125 mutants of herpes simplex virus type 1 thymidine kinase.
    Drake RR; Wilbert TN; Hinds TA; Gilbert KM
    J Biol Chem; 1999 Dec; 274(52):37186-92. PubMed ID: 10601281
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Site-directed mutagenesis of herpes simplex virus type 1 thymidine kinase opposes the importance of amino acid positions 251, 321 and 348 for selective recognition of substrate analogs.
    Michael M; Fetzer J; Folkers G
    Biochem Biophys Res Commun; 1995 Apr; 209(3):966-73. PubMed ID: 7733991
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.