485 related articles for article (PubMed ID: 9799739)
1. Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.
Haas-Kogan D; Shalev N; Wong M; Mills G; Yount G; Stokoe D
Curr Biol; 1998 Oct; 8(21):1195-8. PubMed ID: 9799739
[TBL] [Abstract][Full Text] [Related]
2. Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth.
Edwards LA; Thiessen B; Dragowska WH; Daynard T; Bally MB; Dedhar S
Oncogene; 2005 May; 24(22):3596-605. PubMed ID: 15782140
[TBL] [Abstract][Full Text] [Related]
3. 5' phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cells.
Taylor V; Wong M; Brandts C; Reilly L; Dean NM; Cowsert LM; Moodie S; Stokoe D
Mol Cell Biol; 2000 Sep; 20(18):6860-71. PubMed ID: 10958682
[TBL] [Abstract][Full Text] [Related]
4. PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas.
Nakamura JL; Karlsson A; Arvold ND; Gottschalk AR; Pieper RO; Stokoe D; Haas-Kogan DA
J Neurooncol; 2005 Feb; 71(3):215-22. PubMed ID: 15735908
[TBL] [Abstract][Full Text] [Related]
5. Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions.
Leslie NR; Bennett D; Gray A; Pass I; Hoang-Xuan K; Downes CP
Biochem J; 2001 Jul; 357(Pt 2):427-35. PubMed ID: 11439092
[TBL] [Abstract][Full Text] [Related]
6. Adenoviral transgene expression of MMAC/PTEN in human glioma cells inhibits Akt activation and induces anoikis.
Davies MA; Lu Y; Sano T; Fang X; Tang P; LaPushin R; Koul D; Bookstein R; Stokoe D; Yung WK; Mills GB; Steck PA
Cancer Res; 1998 Dec; 58(23):5285-90. PubMed ID: 9850049
[TBL] [Abstract][Full Text] [Related]
7. Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway.
Ramaswamy S; Nakamura N; Vazquez F; Batt DB; Perera S; Roberts TM; Sellers WR
Proc Natl Acad Sci U S A; 1999 Mar; 96(5):2110-5. PubMed ID: 10051603
[TBL] [Abstract][Full Text] [Related]
8. A role for the actin cytoskeleton in the hormonal and growth-factor-mediated activation of protein kinase B.
Peyrollier K; Hajduch E; Gray A; Litherland GJ; Prescott AR; Leslie NR; Hundal HS
Biochem J; 2000 Dec; 352 Pt 3(Pt 3):617-22. PubMed ID: 11104665
[TBL] [Abstract][Full Text] [Related]
9. Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors.
Freeburn RW; Wright KL; Burgess SJ; Astoul E; Cantrell DA; Ward SG
J Immunol; 2002 Nov; 169(10):5441-50. PubMed ID: 12421919
[TBL] [Abstract][Full Text] [Related]
10. Genetic alterations and aberrant expression of genes related to the phosphatidyl-inositol-3'-kinase/protein kinase B (Akt) signal transduction pathway in glioblastomas.
Knobbe CB; Reifenberger G
Brain Pathol; 2003 Oct; 13(4):507-18. PubMed ID: 14655756
[TBL] [Abstract][Full Text] [Related]
11. The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells.
Asano T; Yao Y; Zhu J; Li D; Abbruzzese JL; Reddy SA
Oncogene; 2004 Nov; 23(53):8571-80. PubMed ID: 15467756
[TBL] [Abstract][Full Text] [Related]
12. Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB.
Stocker H; Andjelkovic M; Oldham S; Laffargue M; Wymann MP; Hemmings BA; Hafen E
Science; 2002 Mar; 295(5562):2088-91. PubMed ID: 11872800
[TBL] [Abstract][Full Text] [Related]
13. The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway.
Arico S; Petiot A; Bauvy C; Dubbelhuis PF; Meijer AJ; Codogno P; Ogier-Denis E
J Biol Chem; 2001 Sep; 276(38):35243-6. PubMed ID: 11477064
[TBL] [Abstract][Full Text] [Related]
14. Src family protein-tyrosine kinases alter the function of PTEN to regulate phosphatidylinositol 3-kinase/AKT cascades.
Lu Y; Yu Q; Liu JH; Zhang J; Wang H; Koul D; McMurray JS; Fang X; Yung WK; Siminovitch KA; Mills GB
J Biol Chem; 2003 Oct; 278(41):40057-66. PubMed ID: 12869565
[TBL] [Abstract][Full Text] [Related]
15. PTEN gene transfer in human malignant glioma: sensitization to irradiation and CD95L-induced apoptosis.
Wick W; Furnari FB; Naumann U; Cavenee WK; Weller M
Oncogene; 1999 Jul; 18(27):3936-43. PubMed ID: 10435616
[TBL] [Abstract][Full Text] [Related]
16. The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway.
Wu X; Senechal K; Neshat MS; Whang YE; Sawyers CL
Proc Natl Acad Sci U S A; 1998 Dec; 95(26):15587-91. PubMed ID: 9861013
[TBL] [Abstract][Full Text] [Related]
17. PTEN, but not SHIP and SHIP2, suppresses the PI3K/Akt pathway and induces growth inhibition and apoptosis of myeloma cells.
Choi Y; Zhang J; Murga C; Yu H; Koller E; Monia BP; Gutkind JS; Li W
Oncogene; 2002 Aug; 21(34):5289-300. PubMed ID: 12149650
[TBL] [Abstract][Full Text] [Related]
18. Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN.
Stambolic V; Suzuki A; de la Pompa JL; Brothers GM; Mirtsos C; Sasaki T; Ruland J; Penninger JM; Siderovski DP; Mak TW
Cell; 1998 Oct; 95(1):29-39. PubMed ID: 9778245
[TBL] [Abstract][Full Text] [Related]
19. Akt regulates COX-2 mRNA and protein expression in mutated-PTEN human endometrial cancer cells.
St-Germain ME; Gagnon V; Mathieu I; Parent S; Asselin E
Int J Oncol; 2004 May; 24(5):1311-24. PubMed ID: 15067356
[TBL] [Abstract][Full Text] [Related]
20. Regulation of phosphoinositide metabolism, Akt phosphorylation, and glucose transport by PTEN (phosphatase and tensin homolog deleted on chromosome 10) in 3T3-L1 adipocytes.
Ono H; Katagiri H; Funaki M; Anai M; Inukai K; Fukushima Y; Sakoda H; Ogihara T; Onishi Y; Fujishiro M; Kikuchi M; Oka Y; Asano T
Mol Endocrinol; 2001 Aug; 15(8):1411-22. PubMed ID: 11463863
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]