BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

134 related articles for article (PubMed ID: 9816221)

  • 1. Polyglutamylation of the dihydrofolate reductase inhibitor gamma-methylene-10-deazaaminopterin is not essential for antitumor activity.
    Cao S; Abraham A; Nair MG; Pati R; Galivan JH; Hausheer FH; Rustum YM
    Clin Cancer Res; 1996 Apr; 2(4):707-12. PubMed ID: 9816221
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Final results of a phase I and pharmacokinetic study of gamma-methylene-10-deazaaminopterin (MDAM) administered intravenously daily for five consecutive days in patients with solid tumors.
    Johansen M; Zukowski T; Hoff PM; Newman RA; Ni D; Hutto T; Abbruzzeese J; Berghorn E; Hausheer F; Madden T
    Cancer Chemother Pharmacol; 2004 May; 53(5):370-6. PubMed ID: 15060739
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Cytotoxicity, uptake, polyglutamate formation, and antileukemic effects of 8-deaza analogues of methotrexate and aminopterin in mice.
    Kuehl M; Brixner DI; Broom AD; Avery TL; Blakley RL
    Cancer Res; 1988 Mar; 48(6):1481-8. PubMed ID: 2449950
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A new analogue of 10-deazaaminopterin with markedly enhanced curative effects against human tumor xenografts in mice.
    Sirotnak FM; DeGraw JI; Colwell WT; Piper JR
    Cancer Chemother Pharmacol; 1998; 42(4):313-8. PubMed ID: 9744777
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Folate analogues. 34. Synthesis and antitumor activity of non-polyglutamylatable inhibitors of dihydrofolate reductase.
    Abraham A; McGuire JJ; Galivan J; Nimec Z; Kisliuk RL; Gaumont Y; Nair MG
    J Med Chem; 1991 Jan; 34(1):222-7. PubMed ID: 1992121
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Antitumor activity of ZD1694 (tomudex) against human head and neck cancer in nude mouse models: role of dosing schedule and plasma thymidine.
    Cao S; McGuire JJ; Rustum YM
    Clin Cancer Res; 1999 Jul; 5(7):1925-34. PubMed ID: 10430100
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Markedly improved efficacy of edatrexate compared to methotrexate in a high-dose regimen with leucovorin rescue against metastatic murine solid tumors.
    Sirotnak FM; Otter GM; Schmid FA
    Cancer Res; 1993 Feb; 53(3):587-91. PubMed ID: 8425192
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Mechanisms of sensitivity and natural resistance to antifolates in a methylcholanthrene-induced rat sarcoma.
    Li WW; Lin JT; Schweitzer BI; Bertino JR
    Mol Pharmacol; 1991 Nov; 40(5):854-8. PubMed ID: 1719370
    [TBL] [Abstract][Full Text] [Related]  

  • 9. 10-Ethyl-10-deaza-aminopterin: structural design and biochemical, pharmacologic, and antitumor properties.
    Sirotnak FM; Schmid FA; Samuels LL; DeGraw JI
    NCI Monogr; 1987; (5):127-31. PubMed ID: 2448650
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Interaction of polyglutamyl derivatives of methotrexate, 10-deazaaminopterin, and dihydrofolate with dihydrofolate reductase.
    Kumar P; Kisliuk RL; Gaumont Y; Nair MG; Baugh CM; Kaufman BT
    Cancer Res; 1986 Oct; 46(10):5020-3. PubMed ID: 2428470
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Syntheses and antifolate activity of 5-methyl-5-deaza analogues of aminopterin, methotrexate, folic acid, and N10-methylfolic acid.
    Piper JR; McCaleb GS; Montgomery JA; Kisliuk RL; Gaumont Y; Sirotnak FM
    J Med Chem; 1986 Jun; 29(6):1080-7. PubMed ID: 2423690
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Similar differential for total polyglutamylation and cytotoxicity among various folate analogues in human and murine tumor cells in vitro.
    Samuels LL; Moccio DM; Sirotnak FM
    Cancer Res; 1985 Apr; 45(4):1488-95. PubMed ID: 3978616
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Novel high-performance liquid chromatographic assay using fluorescence detection for the quantitation of plasma gamma-methylene-10-deazaaminopterin and its major metabolite, 7-hydroxy-gamma-methylene-10-deazaaminopterin, in patients with solid cancers in a phase I trial.
    Su H; Chen TL; Hausheer FH; Rowinsky EK
    J Chromatogr B Biomed Sci Appl; 1997 Aug; 695(2):401-8. PubMed ID: 9300877
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Phase I and pharmacokinetic study of 10-propargyl-10-deazaaminopterin, a new antifolate.
    Krug LM; Ng KK; Kris MG; Miller VA; Tong W; Heelan RT; Leon L; Leung D; Kelly J; Grant SC; Sirotnak FM
    Clin Cancer Res; 2000 Sep; 6(9):3493-8. PubMed ID: 10999734
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Pralatrexate, a dihydrofolate reductase inhibitor for the potential treatment of several malignancies.
    Molina JR
    IDrugs; 2008 Jul; 11(7):508-21. PubMed ID: 18600598
    [TBL] [Abstract][Full Text] [Related]  

  • 16. CEP-7055: a novel, orally active pan inhibitor of vascular endothelial growth factor receptor tyrosine kinases with potent antiangiogenic activity and antitumor efficacy in preclinical models.
    Ruggeri B; Singh J; Gingrich D; Angeles T; Albom M; Yang S; Chang H; Robinson C; Hunter K; Dobrzanski P; Jones-Bolin S; Pritchard S; Aimone L; Klein-Szanto A; Herbert JM; Bono F; Schaeffer P; Casellas P; Bourie B; Pili R; Isaacs J; Ator M; Hudkins R; Vaught J; Mallamo J; Dionne C
    Cancer Res; 2003 Sep; 63(18):5978-91. PubMed ID: 14522925
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Dynamics of antifolate transport via the reduced folate carrier and the membrane folate receptor in murine leukaemia cells in vitro and in vivo.
    Mauritz R; Peters GJ; Kathmann I; Teshale H; Noordhuis P; Comijn EM; Pinedo HM; Jansen G
    Cancer Chemother Pharmacol; 2008 Nov; 62(6):937-48. PubMed ID: 18283461
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and biological evaluation of poly-gamma-glutamyl metabolites of 10-deazaaminopterin and 10-ethyl-10-deazaaminopterin.
    Nair MG; Nanavati NT; Kumar P; Gaumont Y; Kisliuk RL
    J Med Chem; 1988 Jan; 31(1):181-5. PubMed ID: 2447278
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Analysis of "early" thymidine/inosine protection as an adjunct to methotrexate therapy.
    Eleff M; Franks PE; Wampler GL; Collins JM; Goldman ID
    Cancer Treat Rep; 1985; 69(7-8):867-74. PubMed ID: 2410122
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Enhanced polyglutamylation of aminopterin relative to methotrexate in the Ehrlich ascites tumor cell in vitro.
    Matherly LH; Voss MK; Anderson LA; Fry DW; Goldman ID
    Cancer Res; 1985 Mar; 45(3):1073-8. PubMed ID: 2578870
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.