261 related articles for article (PubMed ID: 9822549)
1. Selective tight binding inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase via structure-based drug design.
Aronov AM; Verlinde CL; Hol WG; Gelb MH
J Med Chem; 1998 Nov; 41(24):4790-9. PubMed ID: 9822549
[TBL] [Abstract][Full Text] [Related]
2. Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase.
Aronov AM; Suresh S; Buckner FS; Van Voorhis WC; Verlinde CL; Opperdoes FR; Hol WG; Gelb MH
Proc Natl Acad Sci U S A; 1999 Apr; 96(8):4273-8. PubMed ID: 10200252
[TBL] [Abstract][Full Text] [Related]
3. Conformational changes in Leishmania mexicana glyceraldehyde-3-phosphate dehydrogenase induced by designed inhibitors.
Suresh S; Bressi JC; Kennedy KJ; Verlinde CL; Gelb MH; Hol WG
J Mol Biol; 2001 Jun; 309(2):423-35. PubMed ID: 11371162
[TBL] [Abstract][Full Text] [Related]
4. Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design.
Bressi JC; Verlinde CL; Aronov AM; Shaw ML; Shin SS; Nguyen LN; Suresh S; Buckner FS; Van Voorhis WC; Kuntz ID; Hol WG; Gelb MH
J Med Chem; 2001 Jun; 44(13):2080-93. PubMed ID: 11405646
[TBL] [Abstract][Full Text] [Related]
5. The rational design of trypanocidal drugs: selective inhibition of the glyceraldehyde-3-phosphate dehydrogenase in Trypanosomatidae.
Callens M; Hannaert V
Ann Trop Med Parasitol; 1995 Dec; 89 Suppl 1():23-30. PubMed ID: 8745924
[TBL] [Abstract][Full Text] [Related]
6. Selective inhibition of trypanosomal glyceraldehyde-3-phosphate dehydrogenase by protein structure-based design: toward new drugs for the treatment of sleeping sickness.
Verlinde CL; Callens M; Van Calenbergh S; Van Aerschot A; Herdewijn P; Hannaert V; Michels PA; Opperdoes FR; Hol WG
J Med Chem; 1994 Oct; 37(21):3605-13. PubMed ID: 7932587
[TBL] [Abstract][Full Text] [Related]
7. Adenosine analogues as inhibitors of Trypanosoma brucei phosphoglycerate kinase: elucidation of a novel binding mode for a 2-amino-N(6)-substituted adenosine.
Bressi JC; Choe J; Hough MT; Buckner FS; Van Voorhis WC; Verlinde CL; Hol WG; Gelb MH
J Med Chem; 2000 Nov; 43(22):4135-50. PubMed ID: 11063610
[TBL] [Abstract][Full Text] [Related]
8. Structural considerations for designing adenosine analogs as selective inhibitors of Trichomonas sp. glyceraldehyde-3- phosphate dehydrogenase.
Kundu S; Roy D
In Silico Biol; 2007; 7(6):583-93. PubMed ID: 18467771
[TBL] [Abstract][Full Text] [Related]
9. Synthesis and structure-activity relationships of adenosine analogs as inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase. Modifications at positions 5' and 8.
Aronov AM; Gelb MH
Bioorg Med Chem Lett; 1998 Dec; 8(24):3505-10. PubMed ID: 9934461
[TBL] [Abstract][Full Text] [Related]
10. Structural analysis of human liver glyceraldehyde-3-phosphate dehydrogenase.
Ismail SA; Park HW
Acta Crystallogr D Biol Crystallogr; 2005 Nov; 61(Pt 11):1508-13. PubMed ID: 16239728
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and structure-activity relationships of analogs of 2'-deoxy-2'-(3-methoxybenzamido)adenosine, a selective inhibitor of trypanosomal glycosomal glyceraldehyde-3-phosphate dehydrogenase.
Van Calenbergh S; Verlinde CL; Soenens J; De Bruyn A; Callens M; Blaton NM; Peeters OM; Rozenski J; Hol WG; Herdewijn P
J Med Chem; 1995 Sep; 38(19):3838-49. PubMed ID: 7562915
[TBL] [Abstract][Full Text] [Related]
12. Crystal structure of phosphoglucose isomerase from Trypanosoma brucei complexed with glucose-6-phosphate at 1.6 A resolution.
Arsenieva D; Appavu BL; Mazock GH; Jeffery CJ
Proteins; 2009 Jan; 74(1):72-80. PubMed ID: 18561188
[TBL] [Abstract][Full Text] [Related]
13. (+)-7-Deaza-5'-noraristeromycin as an anti-trypanosomal agent.
Seley KL; Schneller SW; Rattendi D; Bacchi CJ
J Med Chem; 1997 Feb; 40(4):622-4. PubMed ID: 9046353
[TBL] [Abstract][Full Text] [Related]
14. Synthesis of a series of N6-substituted adenosines with activity against trypanosomatid parasites.
Link A; Heidler P; Kaiser M; Brun R
Eur J Med Chem; 2009 Sep; 44(9):3665-71. PubMed ID: 19285758
[TBL] [Abstract][Full Text] [Related]
15. Crystal structure of glycosomal glyceraldehyde-3-phosphate dehydrogenase from Leishmania mexicana: implications for structure-based drug design and a new position for the inorganic phosphate binding site.
Kim H; Feil IK; Verlinde CL; Petra PH; Hol WG
Biochemistry; 1995 Nov; 34(46):14975-86. PubMed ID: 7578111
[TBL] [Abstract][Full Text] [Related]
16. Crystal structure of Leishmania mexicana glycosomal glyceraldehyde-3-phosphate dehydrogenase in a new crystal form confirms the putative physiological active site structure.
Kim H; Hol WG
J Mol Biol; 1998 Apr; 278(1):5-11. PubMed ID: 9571030
[TBL] [Abstract][Full Text] [Related]
17. Evidence for the two phosphate binding sites of an analogue of the thioacyl intermediate for the Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase-catalyzed reaction, from its crystal structure.
Castilho MS; Pavão F; Oliva G; Ladame S; Willson M; Périé J
Biochemistry; 2003 Jun; 42(23):7143-51. PubMed ID: 12795610
[TBL] [Abstract][Full Text] [Related]
18. Discovery of novel Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase inhibitors.
Freitas RF; Prokopczyk IM; Zottis A; Oliva G; Andricopulo AD; Trevisan MT; Vilegas W; Silva MG; Montanari CA
Bioorg Med Chem; 2009 Mar; 17(6):2476-82. PubMed ID: 19254846
[TBL] [Abstract][Full Text] [Related]
19. Structural basis for selective inhibition of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase: molecular docking and 3D QSAR studies.
Guido RV; Oliva G; Montanari CA; Andricopulo AD
J Chem Inf Model; 2008 Apr; 48(4):918-29. PubMed ID: 18303835
[TBL] [Abstract][Full Text] [Related]
20. Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents.
Ohkanda J; Buckner FS; Lockman JW; Yokoyama K; Carrico D; Eastman R; de Luca-Fradley K; Davies W; Croft SL; Van Voorhis WC; Gelb MH; Sebti SM; Hamilton AD
J Med Chem; 2004 Jan; 47(2):432-45. PubMed ID: 14711313
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
