330 related articles for article (PubMed ID: 9822613)
1. Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line.
Wang H; Maechler P; Hagenfeldt KA; Wollheim CB
EMBO J; 1998 Nov; 17(22):6701-13. PubMed ID: 9822613
[TBL] [Abstract][Full Text] [Related]
2. Human insulin gene is a target gene of hepatocyte nuclear factor-1alpha (HNF-1alpha) and HNF-1beta.
Okita K; Yang Q; Yamagata K; Hangenfeldt KA; Miyagawa J; Kajimoto Y; Nakajima H; Namba M; Wollheim CB; Hanafusa T; Matsuzawa Y
Biochem Biophys Res Commun; 1999 Sep; 263(2):566-9. PubMed ID: 10491332
[TBL] [Abstract][Full Text] [Related]
3. A low renal threshold for glucose in diabetic patients with a mutation in the hepatocyte nuclear factor-1alpha (HNF-1alpha) gene.
Menzel R; Kaisaki PJ; Rjasanowski I; Heinke P; Kerner W; Menzel S
Diabet Med; 1998 Oct; 15(10):816-20. PubMed ID: 9796880
[TBL] [Abstract][Full Text] [Related]
4. Structure/function studies of hepatocyte nuclear factor-1alpha, a diabetes-associated transcription factor.
Yang Q; Yamagata K; Yamamoto K; Miyagawa J; Takeda J; Iwasaki N; Iwahashi H; Yoshiuchi I; Namba M; Miyazaki J; Hanafusa T; Matsuzawa Y
Biochem Biophys Res Commun; 1999 Dec; 266(1):196-202. PubMed ID: 10581189
[TBL] [Abstract][Full Text] [Related]
5. Regulation of human insulin, IGF-I, and multidrug resistance protein 2 promoter activity by hepatocyte nuclear factor (HNF)-1beta and HNF-1alpha and the abnormality of HNF-1beta mutants.
Kitanaka S; Sato U; Igarashi T
J Endocrinol; 2007 Jan; 192(1):141-7. PubMed ID: 17210751
[TBL] [Abstract][Full Text] [Related]
6. MODY associated with two novel hepatocyte nuclear factor-1alpha loss-of-function mutations (P112L and Q466X).
Bjørkhaug L; Ye H; Horikawa Y; Søvik O; Molven A; Njølstad PR
Biochem Biophys Res Commun; 2000 Dec; 279(3):792-8. PubMed ID: 11162430
[TBL] [Abstract][Full Text] [Related]
7. Molecular targets of a human HNF1 alpha mutation responsible for pancreatic beta-cell dysfunction.
Wang H; Antinozzi PA; Hagenfeldt KA; Maechler P; Wollheim CB
EMBO J; 2000 Aug; 19(16):4257-64. PubMed ID: 10944108
[TBL] [Abstract][Full Text] [Related]
8. Identification of seven novel nucleotide variants in the hepatocyte nuclear factor-1alpha (TCF1) promoter region in MODY patients.
Godart F; Bellanné-Chantelot C; Clauin S; Gragnoli C; Abderrahmani A; Blanché H; Boutin P; Chèvre JC; Froguel P; Bailleul B
Hum Mutat; 2000; 15(2):173-80. PubMed ID: 10649494
[TBL] [Abstract][Full Text] [Related]
9. Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3).
Yamagata K; Oda N; Kaisaki PJ; Menzel S; Furuta H; Vaxillaire M; Southam L; Cox RD; Lathrop GM; Boriraj VV; Chen X; Cox NJ; Oda Y; Yano H; Le Beau MM; Yamada S; Nishigori H; Takeda J; Fajans SS; Hattersley AT; Iwasaki N; Hansen T; Pedersen O; Polonsky KS; Bell GI
Nature; 1996 Dec; 384(6608):455-8. PubMed ID: 8945470
[TBL] [Abstract][Full Text] [Related]
10. Hepatocyte nuclear factor-1alpha modulates pancreatic beta-cell growth by regulating the expression of insulin-like growth factor-1 in INS-1 cells.
Yang Q; Yamagata K; Fukui K; Cao Y; Nammo T; Iwahashi H; Wang H; Matsumura I; Hanafusa T; Bucala R; Wollheim CB; Miyagawa J; Matsuzawa Y
Diabetes; 2002 Jun; 51(6):1785-92. PubMed ID: 12031966
[TBL] [Abstract][Full Text] [Related]
11. Effect of mutations in HNF-1alpha and HNF-1beta on the transcriptional regulation of human sucrase-isomaltase in Caco-2 cells.
Gu N; Suzuki N; Takeda J; Adachi T; Tsujimoto G; Aoki N; Ishihara A; Tsuda K; Yasuda K
Biochem Biophys Res Commun; 2004 Dec; 325(1):308-13. PubMed ID: 15522234
[TBL] [Abstract][Full Text] [Related]
12. Cloning and characterization of the human beta2-glycoprotein I (beta2-GPI) gene promoter: roles of the atypical TATA box and hepatic nuclear factor-1alpha in regulating beta2-GPI promoter activity.
Wang HH; Chiang AN
Biochem J; 2004 Jun; 380(Pt 2):455-63. PubMed ID: 14984368
[TBL] [Abstract][Full Text] [Related]
13. A novel dominant-negative mutation of the hepatocyte nuclear factor-1alpha gene in Japanese early-onset type 2 diabetes.
Tanaka S; Kobayashi T; Tomura H; Okubo M; Nakanishi K; Takeda J; Murase T
Horm Metab Res; 2000 Sep; 32(9):373-7. PubMed ID: 11014387
[TBL] [Abstract][Full Text] [Related]
14. Expression profile of MODY3/HNF-1alpha protein in the developing mouse pancreas.
Nammo T; Yamagata K; Hamaoka R; Zhu Q; Akiyama TE; Gonzalez FJ; Miyagawa J; Matsuzawa Y
Diabetologia; 2002 Aug; 45(8):1142-53. PubMed ID: 12189445
[TBL] [Abstract][Full Text] [Related]
15. Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism.
Shih DQ; Screenan S; Munoz KN; Philipson L; Pontoglio M; Yaniv M; Polonsky KS; Stoffel M
Diabetes; 2001 Nov; 50(11):2472-80. PubMed ID: 11679424
[TBL] [Abstract][Full Text] [Related]
16. Growth hormone regulates the expression of hepatocyte nuclear factor-3 gamma and other liver-enriched transcription factors in the bovine liver.
Eleswarapu S; Jiang H
J Endocrinol; 2005 Jan; 184(1):95-105. PubMed ID: 15642787
[TBL] [Abstract][Full Text] [Related]
17. Abnormal splicing of hepatocyte nuclear factor 1 alpha in maturity-onset diabetes of the young.
Bulman MP; Harries LW; Hansen T; Shepherd M; Kelly WF; Hattersley AT; Ellard S
Diabetologia; 2002 Oct; 45(10):1463-7. PubMed ID: 12378390
[TBL] [Abstract][Full Text] [Related]
18. Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets.
Pongratz RL; Kibbey RG; Kirkpatrick CL; Zhao X; Pontoglio M; Yaniv M; Wollheim CB; Shulman GI; Cline GW
J Biol Chem; 2009 Jun; 284(25):16808-16821. PubMed ID: 19376774
[TBL] [Abstract][Full Text] [Related]
19. Structural basis of dimerization, coactivator recognition and MODY3 mutations in HNF-1alpha.
Rose RB; Bayle JH; Endrizzi JA; Cronk JD; Crabtree GR; Alber T
Nat Struct Biol; 2000 Sep; 7(9):744-8. PubMed ID: 10966642
[TBL] [Abstract][Full Text] [Related]
20. Identification of a new mutation in the hepatocyte nuclear factor-1alpha gene in a Polish family with early-onset type 2 diabetes mellitus.
Malecki MT; Klupa T; Frey J; Cyganek K; Galicka-Stankowska D; Wanic K; Sieradzki J
Diabetes Nutr Metab; 2001 Oct; 14(5):288-91. PubMed ID: 11806470
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]