These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

160 related articles for article (PubMed ID: 9826650)

  • 1. Structural basis for efficient phosphorylation of 3'-azidothymidine monophosphate by Escherichia coli thymidylate kinase.
    Lavie A; Ostermann N; Brundiers R; Goody RS; Reinstein J; Konrad M; Schlichting I
    Proc Natl Acad Sci U S A; 1998 Nov; 95(24):14045-50. PubMed ID: 9826650
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-thymidyl) pentaphosphate (TP5A) at 2.0 A resolution: implications for catalysis and AZT activation.
    Lavie A; Konrad M; Brundiers R; Goody RS; Schlichting I; Reinstein J
    Biochemistry; 1998 Mar; 37(11):3677-86. PubMed ID: 9521686
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structural basis for the efficient phosphorylation of AZT-MP (3'-azido-3'-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinase.
    Whittingham JL; Carrero-Lerida J; Brannigan JA; Ruiz-Perez LM; Silva AP; Fogg MJ; Wilkinson AJ; Gilbert IH; Wilson KS; González-Pacanowska D
    Biochem J; 2010 May; 428(3):499-509. PubMed ID: 20353400
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Modifying human thymidylate kinase to potentiate azidothymidine activation.
    Brundiers R; Lavie A; Veit T; Reinstein J; Schlichting I; Ostermann N; Goody RS; Konrad M
    J Biol Chem; 1999 Dec; 274(50):35289-92. PubMed ID: 10585390
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Potentiating AZT activation: structures of wild-type and mutant human thymidylate kinase suggest reasons for the mutants' improved kinetics with the HIV prodrug metabolite AZTMP.
    Ostermann N; Lavie A; Padiyar S; Brundiers R; Veit T; Reinstein J; Goody RS; Konrad M; Schlichting I
    J Mol Biol; 2000 Nov; 304(1):43-53. PubMed ID: 11071809
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The crystal structure of Mycobacterium tuberculosis thymidylate kinase in complex with 3'-azidodeoxythymidine monophosphate suggests a mechanism for competitive inhibition.
    Fioravanti E; Adam V; Munier-Lehmann H; Bourgeois D
    Biochemistry; 2005 Jan; 44(1):130-7. PubMed ID: 15628853
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structural requirements for efficient phosphorylation of nucleotide analogs by human thymidylate kinase.
    Lavie A; Konrad M
    Mini Rev Med Chem; 2004 May; 4(4):351-9. PubMed ID: 15134538
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Sugar specificity of bacterial CMP kinases as revealed by crystal structures and mutagenesis of Escherichia coli enzyme.
    Bertrand T; Briozzo P; Assairi L; Ofiteru A; Bucurenci N; Munier-Lehmann H; Golinelli-Pimpaneau B; Bârzu O; Gilles AM
    J Mol Biol; 2002 Feb; 315(5):1099-110. PubMed ID: 11827479
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation.
    Lavie A; Vetter IR; Konrad M; Goody RS; Reinstein J; Schlichting I
    Nat Struct Biol; 1997 Aug; 4(8):601-4. PubMed ID: 9253404
    [No Abstract]   [Full Text] [Related]  

  • 10. Restoration of the antiviral activity of 3'-azido-3'-deoxythymidine (AZT) against AZT-resistant human immunodeficiency virus by delivery of engineered thymidylate kinase to T cells.
    Lavie A; Su Y; Ghassemi M; Novak RM; Caffrey M; Sekulic N; Monnerjahn C; Konrad M; Cook JL
    J Gen Virol; 2008 Jul; 89(Pt 7):1672-1679. PubMed ID: 18559937
    [TBL] [Abstract][Full Text] [Related]  

  • 11. The highly similar TMP kinases of Yersinia pestis and Escherichia coli differ markedly in their AZTMP phosphorylating activity.
    Chenal-Francisque V; Tourneux L; Carniel E; Christova P; Li de la Sierra I; Bârzu O; Gilles AM
    Eur J Biochem; 1999 Oct; 265(1):112-9. PubMed ID: 10491164
    [TBL] [Abstract][Full Text] [Related]  

  • 12. 3'-Azidothymidine in the active site of Escherichia coli thymidine phosphorylase: the peculiarity of the binding on the basis of X-ray study.
    Timofeev V; Abramchik Y; Zhukhlistova N; Muravieva T; Fateev I; Esipov R; Kuranova I
    Acta Crystallogr D Biol Crystallogr; 2014 Apr; 70(Pt 4):1155-65. PubMed ID: 24699659
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Transgenic cardiac-targeted overexpression of human thymidylate kinase.
    Kohler JJ; Hosseini SH; Cucoranu I; Zhelyabovska O; Green E; Ivey K; Abuin A; Fields E; Hoying A; Russ R; Santoianni R; Raper CM; Yang Q; Lavie A; Lewis W
    Lab Invest; 2010 Mar; 90(3):383-90. PubMed ID: 20065942
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mycobacterium tuberculosis thymidylate kinase: structural studies of intermediates along the reaction pathway.
    Fioravanti E; Haouz A; Ursby T; Munier-Lehmann H; Delarue M; Bourgeois D
    J Mol Biol; 2003 Apr; 327(5):1077-92. PubMed ID: 12662932
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Insights into the phosphoryltransfer mechanism of human thymidylate kinase gained from crystal structures of enzyme complexes along the reaction coordinate.
    Ostermann N; Schlichting I; Brundiers R; Konrad M; Reinstein J; Veit T; Goody RS; Lavie A
    Structure; 2000 Jun; 8(6):629-42. PubMed ID: 10873853
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structural and functional analysis of human thymidylate kinase isoforms.
    Hu Frisk J; Pejler G; Eriksson S; Wang L
    Nucleosides Nucleotides Nucleic Acids; 2022; 41(3):321-332. PubMed ID: 34994281
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mechanisms of substrate selectivity for Bacillus anthracis thymidylate kinase.
    Carnrot C; Wang L; Topalis D; Eriksson S
    Protein Sci; 2008 Sep; 17(9):1486-93. PubMed ID: 18523102
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Novel nucleotide analogues as potential substrates for TMPK, a key enzyme in the metabolism of AZT.
    Müller HC; Meier C; Balzarini J; Reinstein J
    Nucleosides Nucleotides Nucleic Acids; 2003; 22(5-8):821-3. PubMed ID: 14565287
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Ethanol decreases the efficiency of phosphorylation of thymidine kinase in a human T-lymphocytic cell line.
    Prakash O; Tang ZY; Zhou P; Peng X; Kolls J; Shellito JE; Nelson S
    Alcohol Clin Exp Res; 2002 Mar; 26(3):295-302. PubMed ID: 11923581
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Thymidylate kinase: an old topic brings new perspectives.
    Cui Q; Shin WS; Luo Y; Tian J; Cui H; Yin D
    Curr Med Chem; 2013; 20(10):1286-305. PubMed ID: 23394555
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.