128 related articles for article (PubMed ID: 9839000)
1. Synthesis and in vitro activity of some epimeric 20 alpha-hydroxy, 20-oxime and aziridine pregnene derivatives as inhibitors of human 17 alpha-hydroxylase/C17,20-lyase and 5 alpha-reductase.
Ling YZ; Li JS; Kato K; Liu Y; Wang X; Klus GT; Marat K; Nnane IP; Brodie AM
Bioorg Med Chem; 1998 Oct; 6(10):1683-93. PubMed ID: 9839000
[TBL] [Abstract][Full Text] [Related]
2. Synthesis and evaluation of novel steroidal oxime inhibitors of P450 17 (17 alpha-hydroxylase/C17-20-lyase) and 5 alpha-reductase types 1 and 2.
Hartmann RW; Hector M; Haidar S; Ehmer PB; Reichert W; Jose J
J Med Chem; 2000 Nov; 43(22):4266-77. PubMed ID: 11063622
[TBL] [Abstract][Full Text] [Related]
3. Synthesis and evaluation of 17-aliphatic heterocycle-substituted steroidal inhibitors of 17alpha-hydroxylase/C17-20-lyase (P450 17).
Hartmann RW; Hector M; Wachall BG; Palusczak A; Palzer M; Huch V; Veith M
J Med Chem; 2000 Nov; 43(23):4437-45. PubMed ID: 11087568
[TBL] [Abstract][Full Text] [Related]
4. 20-amino and 20,21-aziridinyl pregnene steroids: development of potent inhibitors of 17 alpha-hydroxylase/C17,20-lyase (P450 17).
Njar VC; Hector M; Hartmann RW
Bioorg Med Chem; 1996 Sep; 4(9):1447-53. PubMed ID: 8894102
[TBL] [Abstract][Full Text] [Related]
5. 17-Imidazolyl, pyrazolyl, and isoxazolyl androstene derivatives. Novel steroidal inhibitors of human cytochrome C17,20-lyase (P450(17 alpha).
Ling YZ; Li JS; Liu Y; Kato K; Klus GT; Brodie A
J Med Chem; 1997 Sep; 40(20):3297-304. PubMed ID: 9379450
[TBL] [Abstract][Full Text] [Related]
6. Inhibition of androgen synthesis by 22-hydroximino-23,24-bisnor-4-cholen-3-one.
Li J; Li Y; Son C; Brodie AM
Prostate; 1995 Mar; 26(3):140-50. PubMed ID: 7534917
[TBL] [Abstract][Full Text] [Related]
7. Novel 17-azolyl steroids, potent inhibitors of human cytochrome 17 alpha-hydroxylase-C17,20-lyase (P450(17) alpha): potential agents for the treatment of prostate cancer.
Njar VC; Kato K; Nnane IP; Grigoryev DN; Long BJ; Brodie AM
J Med Chem; 1998 Mar; 41(6):902-12. PubMed ID: 9526564
[TBL] [Abstract][Full Text] [Related]
8. Synthesis and evaluation of pregnane derivatives as inhibitors of human testicular 17 alpha-hydroxylase/C17,20-lyase.
Li JS; Li Y; Son C; Brodie AM
J Med Chem; 1996 Oct; 39(21):4335-9. PubMed ID: 8863811
[TBL] [Abstract][Full Text] [Related]
9. Effects of some novel inhibitors of C17,20-lyase and 5alpha-reductase in vitro and in vivo and their potential role in the treatment of prostate cancer.
Nnane IP; Kato K; Liu Y; Lu Q; Wang X; Ling YZ; Brodie A
Cancer Res; 1998 Sep; 58(17):3826-32. PubMed ID: 9731491
[TBL] [Abstract][Full Text] [Related]
10. Inhibition of androgen synthesis in human testicular and prostatic microsomes and in male rats by novel steroidal compounds.
Nnane IP; Kato K; Liu Y; Long BJ; Lu Q; Wang X; Ling YZ; Brodie A
Endocrinology; 1999 Jun; 140(6):2891-7. PubMed ID: 10342882
[TBL] [Abstract][Full Text] [Related]
11. 4-pregnene-3-one-20 beta-carboxaldehyde: a potent inhibitor of 17 alpha-hydroxylase/C17,20-lyase and of 5 alpha-reductase.
Li J; Li Y; Son C; Banks P; Brodie A
J Steroid Biochem Mol Biol; 1992 May; 42(3-4):313-20. PubMed ID: 1606043
[TBL] [Abstract][Full Text] [Related]
12. Effects of novel 17alpha-hydroxylase/C17, 20-lyase (P450 17, CYP 17) inhibitors on androgen biosynthesis in vitro and in vivo.
Haidar S; Ehmer PB; Barassin S; Batzl-Hartmann C; Hartmann RW
J Steroid Biochem Mol Biol; 2003 Apr; 84(5):555-62. PubMed ID: 12767280
[TBL] [Abstract][Full Text] [Related]
13. Synthesis of novel oximes of 2-aryl-6-methoxy-3,4-dihydronaphthalene and their evaluation as inhibitors of 17 alpha-hydroxylase-C17,20-lyase (P450 17).
Zhuang Y; Hartmann RW
Arch Pharm (Weinheim); 1998 Jan; 331(1):36-40. PubMed ID: 9507700
[TBL] [Abstract][Full Text] [Related]
14. YM116, 2-(1H-imidazol-4-ylmethyl)-9H-carbazole, decreases adrenal androgen synthesis by inhibiting C17-20 lyase activity in NCI-H295 human adrenocortical carcinoma cells.
Ideyama Y; Kudoh M; Tanimoto K; Susaki Y; Nanya T; Nakahara T; Ishikawa H; Fujikura T; Akaza H; Shikama H
Jpn J Pharmacol; 1999 Feb; 79(2):213-20. PubMed ID: 10202857
[TBL] [Abstract][Full Text] [Related]
15. 3- and 4-pyridylalkyl adamantanecarboxylates: inhibitors of human cytochrome P450(17 alpha) (17 alpha-hydroxylase/C17,20-lyase). Potential nonsteroidal agents for the treatment of prostatic cancer.
Chan FC; Potter GA; Barrie SE; Haynes BP; Rowlands MG; Houghton J; Jarman M
J Med Chem; 1996 Aug; 39(17):3319-23. PubMed ID: 8765515
[TBL] [Abstract][Full Text] [Related]
16. Synthesis of novel 21-trifluoropregnane steroids: inhibitors of 17 alpha-hydroxylase/17,20-lyase (17 alpha-lyase).
Njar VC; Klus GT; Johnson HH; Brodie AM
Steroids; 1997 Jun; 62(6):468-73. PubMed ID: 9185294
[TBL] [Abstract][Full Text] [Related]
17. A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase.
Recanatini M; Bisi A; Cavalli A; Belluti F; Gobbi S; Rampa A; Valenti P; Palzer M; Palusczak A; Hartmann RW
J Med Chem; 2001 Mar; 44(5):672-80. PubMed ID: 11262078
[TBL] [Abstract][Full Text] [Related]
18. Synthesis of Z- and E-1-methyl-2-(1-hydroximinoethyl)-6-methoxy-3,4-dihydronaphthalene and evaluation as inhibitors of 17 alpha-hydroxylase-C17,20-lyase (P450 17).
Zhuang Y; Zapp J; Hartmann RW
Arch Pharm (Weinheim); 1997 Nov; 330(11):359-61. PubMed ID: 9431028
[TBL] [Abstract][Full Text] [Related]
19. Synthesis, 17α-hydroxylase-C
Banday AH; Shameem SA; Banday JA; Ganaie BA
Anticancer Agents Med Chem; 2018; 18(13):1919-1926. PubMed ID: 29697032
[TBL] [Abstract][Full Text] [Related]
20. In vivo and in vitro effect of novel 4,16-pregnadiene-6,20-dione derivatives, as 5alpha-reductase inhibitors.
Bratoeff E; Cabeza M; Pérez-Ornelas V; Recillas S; Heuze I
J Steroid Biochem Mol Biol; 2008 Sep; 111(3-5):275-81. PubMed ID: 18644453
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
