125 related articles for article (PubMed ID: 9855017)
21. Organ specificity of DNA adduct formation by tamoxifen and alpha-hydroxytamoxifen in the rat: implications for understanding the mechanism(s) of tamoxifen carcinogenicity and for human risk assessment.
Phillips DH; Hewer A; Osborne MR; Cole KJ; Churchill C; Arlt VM
Mutagenesis; 2005 Jul; 20(4):297-303. PubMed ID: 15928012
[TBL] [Abstract][Full Text] [Related]
22. Alpha-hydroxylation of tamoxifen and toremifene by human and rat cytochrome P450 3A subfamily enzymes.
Kim SY; Suzuki N; Santosh Laxmi YR; Rieger R; Shibutani S
Chem Res Toxicol; 2003 Sep; 16(9):1138-44. PubMed ID: 12971802
[TBL] [Abstract][Full Text] [Related]
23. Preparation of oligodeoxynucleotides containing a diastereoisomer of alpha-(N(2)-2'-deoxyguanosinyl)tamoxifen by phosphoramidite chemical synthesis.
Santosh Laxmi YR; Suzuki N; Dasaradhi L; Johnson F; Shibutani S
Chem Res Toxicol; 2002 Feb; 15(2):218-25. PubMed ID: 11849048
[TBL] [Abstract][Full Text] [Related]
24. Major inter-species differences in the rates of O-sulphonation and O-glucuronylation of alpha-hydroxytamoxifen in vitro: a metabolic disparity protecting human liver from the formation of tamoxifen-DNA adducts.
Boocock DJ; Maggs JL; Brown K; White IN; Park BK
Carcinogenesis; 2000 Oct; 21(10):1851-8. PubMed ID: 11023543
[TBL] [Abstract][Full Text] [Related]
25. 4-Hydroxytamoxifen gives DNA adducts by chemical activation, but not in rat liver cells.
Osborne MR; Davis W; Hewer AJ; Hardcastle IR; Phillips DH
Chem Res Toxicol; 1999 Feb; 12(2):151-8. PubMed ID: 10027792
[TBL] [Abstract][Full Text] [Related]
26. Identification of three major DNA adducts formed by the carcinogenic air pollutant 3-nitrobenzanthrone in rat lung at the C8 and N2 position of guanine and at the N6 position of adenine.
Arlt VM; Schmeiser HH; Osborne MR; Kawanishi M; Kanno T; Yagi T; Phillips DH; Takamura-Enya T
Int J Cancer; 2006 May; 118(9):2139-46. PubMed ID: 16331602
[TBL] [Abstract][Full Text] [Related]
27. Identification of tamoxifen-DNA adducts formed by alpha-sulfate tamoxifen and alpha-acetoxytamoxifen.
Dasaradhi L; Shibutani S
Chem Res Toxicol; 1997 Feb; 10(2):189-96. PubMed ID: 9049430
[TBL] [Abstract][Full Text] [Related]
28. Reverse geometrical selectivity in glucuronidation and sulfation of cis- and trans-4-hydroxytamoxifens by human liver UDP-glucuronosyltransferases and sulfotransferases.
Nishiyama T; Ogura K; Nakano H; Ohnuma T; Kaku T; Hiratsuka A; Muro K; Watabe T
Biochem Pharmacol; 2002 May; 63(10):1817-30. PubMed ID: 12034366
[TBL] [Abstract][Full Text] [Related]
29. Mechanism of lower genotoxicity of toremifene compared with tamoxifen.
Shibutani S; Ravindernath A; Terashima I; Suzuki N; Laxmi YR; Kanno Y; Suzuki M; Apak TI; Sheng JJ; Duffel MW
Cancer Res; 2001 May; 61(10):3925-31. PubMed ID: 11358807
[TBL] [Abstract][Full Text] [Related]
30. Characterization of the major DNA adducts in the liver of rats chronically exposed to tamoxifen for 18 months.
Firozi PF; Vulimiri SV; Rajaniemi H; Hemminki K; Dragan Y; Pitot HC; DiGiovanni J; Zhu YH; Li D
Chem Biol Interact; 2000 Apr; 126(1):33-43. PubMed ID: 10826652
[TBL] [Abstract][Full Text] [Related]
31. Antioxidant inhibits tamoxifen-DNA adducts in endometrial explant culture.
Sharma M; Shubert DE; Sharma M; Rodabaugh KJ; McGarrigle BP; Vezina CM; Bofinger DP; Olson JR
Biochem Biophys Res Commun; 2003 Jul; 307(1):157-64. PubMed ID: 12849995
[TBL] [Abstract][Full Text] [Related]
32. DNA binding of tamoxifen and its analogues: identification of the tamoxifen-DNA adducts in rat liver.
Rajaniemi H; Koskinen M; Mäntylä E; Hemminki K
Toxicol Lett; 1998 Dec; 102-103():453-7. PubMed ID: 10022295
[TBL] [Abstract][Full Text] [Related]
33. Tamoxifen metabolic activation: comparison of DNA adducts formed by microsomal and chemical activation of tamoxifen and 4-hydroxytamoxifen with DNA adducts formed in vivo.
Moorthy B; Sriram P; Pathak DN; Bodell WJ; Randerath K
Cancer Res; 1996 Jan; 56(1):53-7. PubMed ID: 8548775
[TBL] [Abstract][Full Text] [Related]
34. Idoxifene derivatives are less reactive to DNA than tamoxifen derivatives, both chemically and in human and rat liver cells.
Osborne MR; Hewer A; Davis W; Strain AJ; Keogh A; Hardcastle IR; Phillips DH
Carcinogenesis; 1999 Feb; 20(2):293-7. PubMed ID: 10069467
[TBL] [Abstract][Full Text] [Related]
35. Electrospray ionization-tandem mass spectrometry and 32P-postlabeling analyses of tamoxifen-DNA adducts in humans.
Beland FA; Churchwell MI; Doerge DR; Parkin DR; Malejka-Giganti D; Hewer A; Phillips DH; Carmichael PL; Gamboa da Costa G; Marques MM
J Natl Cancer Inst; 2004 Jul; 96(14):1099-104. PubMed ID: 15265972
[TBL] [Abstract][Full Text] [Related]
36. Genotoxic mechanism of tamoxifen in developing endometrial cancer.
Kim SY; Suzuki N; Laxmi YR; Shibutani S
Drug Metab Rev; 2004 May; 36(2):199-218. PubMed ID: 15237851
[TBL] [Abstract][Full Text] [Related]
37. Microsomal and peroxidase activation of 4-hydroxy-tamoxifen to form DNA adducts: comparison with DNA adducts formed in Sprague-Dawley rats treated with tamoxifen.
Pathak DN; Pongracz K; Bodell WJ
Carcinogenesis; 1995 Jan; 16(1):11-5. PubMed ID: 7834794
[TBL] [Abstract][Full Text] [Related]
38. alpha-Hydroxytamoxifen, a metabolite of tamoxifen with exceptionally high DNA-binding activity in rat hepatocytes.
Phillips DH; Carmichael PL; Hewer A; Cole KJ; Poon GK
Cancer Res; 1994 Nov; 54(21):5518-22. PubMed ID: 7923188
[TBL] [Abstract][Full Text] [Related]
39. Evaluation of tamoxifen and alpha-hydroxytamoxifen 32P-post-labelled DNA adducts by the development of a novel automated on-line solid-phase extraction HPLC method.
Martin EA; Heydon RT; Brown K; Brown JE; Lim CK; White IN; Smith LL
Carcinogenesis; 1998 Jun; 19(6):1061-9. PubMed ID: 9667745
[TBL] [Abstract][Full Text] [Related]
40. Tamoxifen-DNA adducts formed by alpha-acetoxytamoxifen N-oxide.
Umemoto A; Monden Y; Komaki K; Suwa M; Kanno Y; Suzuki M; Lin CX; Ueyama Y; Momen MA; Ravindernath A; Shibutani S
Chem Res Toxicol; 1999 Nov; 12(11):1083-9. PubMed ID: 10563834
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]
