These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

108 related articles for article (PubMed ID: 9860824)

  • 1. Approaching the transition state in the crystal structure of a phosphoribosyltransferase.
    Focia PJ; Craig SP; Eakin AE
    Biochemistry; 1998 Dec; 37(49):17120-7. PubMed ID: 9860824
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A 1.4 A crystal structure for the hypoxanthine phosphoribosyltransferase of Trypanosoma cruzi.
    Focia PJ; Craig SP; Nieves-Alicea R; Fletterick RJ; Eakin AE
    Biochemistry; 1998 Oct; 37(43):15066-75. PubMed ID: 9790669
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The crystal structure of free human hypoxanthine-guanine phosphoribosyltransferase reveals extensive conformational plasticity throughout the catalytic cycle.
    Keough DT; Brereton IM; de Jersey J; Guddat LW
    J Mol Biol; 2005 Aug; 351(1):170-81. PubMed ID: 15990111
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Crystal structure of the dimeric phosphoenolpyruvate carboxykinase (PEPCK) from Trypanosoma cruzi at 2 A resolution.
    Trapani S; Linss J; Goldenberg S; Fischer H; Craievich AF; Oliva G
    J Mol Biol; 2001 Nov; 313(5):1059-72. PubMed ID: 11700062
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Ternary complex structure of human HGPRTase, PRPP, Mg2+, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding.
    Balendiran GK; Molina JA; Xu Y; Torres-Martinez J; Stevens R; Focia PJ; Eakin AE; Sacchettini JC; Craig SP
    Protein Sci; 1999 May; 8(5):1023-31. PubMed ID: 10338013
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Efficient identification of inhibitors targeting the closed active site conformation of the HPRT from Trypanosoma cruzi.
    Freymann DM; Wenck MA; Engel JC; Feng J; Focia PJ; Eakin AE; Craig SP
    Chem Biol; 2000 Dec; 7(12):957-68. PubMed ID: 11137818
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structural and functional studies of the human phosphoribosyltransferase domain containing protein 1.
    Welin M; Egeblad L; Johansson A; Stenmark P; Wang L; Flodin S; Nyman T; Trésaugues L; Kotenyova T; Johansson I; Eriksson S; Eklund H; Nordlund P
    FEBS J; 2010 Dec; 277(23):4920-30. PubMed ID: 21054786
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Ternary complex formation and induced asymmetry in orotate phosphoribosyltransferase.
    González-Segura L; Witte JF; McClard RW; Hurley TD
    Biochemistry; 2007 Dec; 46(49):14075-86. PubMed ID: 18020427
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Substrate deformation in a hypoxanthine-guanine phosphoribosyltransferase ternary complex: the structural basis for catalysis.
    Héroux A; White EL; Ross LJ; Kuzin AP; Borhani DW
    Structure; 2000 Dec; 8(12):1309-18. PubMed ID: 11188695
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structures of dihydrofolate reductase-thymidylate synthase of Trypanosoma cruzi in the folate-free state and in complex with two antifolate drugs, trimetrexate and methotrexate.
    Senkovich O; Schormann N; Chattopadhyay D
    Acta Crystallogr D Biol Crystallogr; 2009 Jul; 65(Pt 7):704-16. PubMed ID: 19564691
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Crystal structure of a chimera of human and Plasmodium falciparum hypoxanthine guanine phosphoribosyltransferases provides insights into oligomerization.
    Gayathri P; Sujay Subbayya IN; Ashok CS; Selvi TS; Balaram H; Murthy MR
    Proteins; 2008 Dec; 73(4):1010-20. PubMed ID: 18536021
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Crystal structure of Toxoplasma gondii hypoxanthine-guanine phosphoribosyltransferase with XMP, pyrophosphate, and two Mg(2+) ions bound: insights into the catalytic mechanism.
    Héroux A; White EL; Ross LJ; Davis RL; Borhani DW
    Biochemistry; 1999 Nov; 38(44):14495-506. PubMed ID: 10545171
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Saturation mutagenesis, complement selection, and steady-state kinetic studies illuminate the roles of invariant residues in active site loop I of the hypoxanthine phosphoribosyltransferase from Trypanosoma cruzi.
    Butterworth AC; Medrano FJ; Eakin AE; Craig SP
    Biochim Biophys Acta; 2004 Jun; 1699(1-2):87-94. PubMed ID: 15158715
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Crystal structure of the hypoxanthine-guanine-xanthine phosphoribosyltransferase from the protozoan parasite Tritrichomonas foetus.
    Somoza JR; Chin MS; Focia PJ; Wang CC; Fletterick RJ
    Biochemistry; 1996 Jun; 35(22):7032-40. PubMed ID: 8679528
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The 2.0 A structure of malarial purine phosphoribosyltransferase in complex with a transition-state analogue inhibitor.
    Shi W; Li CM; Tyler PC; Furneaux RH; Cahill SM; Girvin ME; Grubmeyer C; Schramm VL; Almo SC
    Biochemistry; 1999 Aug; 38(31):9872-80. PubMed ID: 10433693
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Alternative IMP binding in feedback inhibition of hypoxanthine-guanine phosphoribosyltransferase from Thermoanaerobacter tengcongensis.
    Chen Q; Liang Y; Su X; Gu X; Zheng X; Luo M
    J Mol Biol; 2005 May; 348(5):1199-210. PubMed ID: 15854655
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Unusual substrate specificity of a chimeric hypoxanthine-guanine phosphoribosyltransferase containing segments from the Plasmodium falciparum and human enzymes.
    Sujay Subbayya IN; Sukumaran S; Shivashankar K; Balaram H
    Biochem Biophys Res Commun; 2000 Jun; 272(2):596-602. PubMed ID: 10833458
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Conformational flexibility of PEP mutase.
    Liu S; Lu Z; Han Y; Jia Y; Howard A; Dunaway-Mariano D; Herzberg O
    Biochemistry; 2004 Apr; 43(15):4447-53. PubMed ID: 15078090
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Investigation of the functional role of active site loop II in a hypoxanthine phosphoribosyltransferase.
    Lee CC; Medrano FJ; Craig SP; Eakin AE
    Biochim Biophys Acta; 2001 Jul; 1537(1):63-70. PubMed ID: 11476964
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Crystal structure of the purine nucleoside phosphorylase (PNP) from Cellulomonas sp. and its implication for the mechanism of trimeric PNPs.
    Tebbe J; Bzowska A; Wielgus-Kutrowska B; Schröder W; Kazimierczuk Z; Shugar D; Saenger W; Koellner G
    J Mol Biol; 1999 Dec; 294(5):1239-55. PubMed ID: 10600382
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.