149 related articles for article (PubMed ID: 9871511)
1. Peptidyl human heart chymase inhibitors. 1. Synthesis and inhibitory activity of difluoromethylene ketone derivatives bearing P' binding subsites.
Eda M; Ashimori A; Akahoshi F; Yoshimura T; Inoue Y; Fukaya C; Nakajima M; Fukuyama H; Imada T; Takai S; Shiota N; Miyazaki M; Nakamura N
Bioorg Med Chem Lett; 1998 Apr; 8(8):913-8. PubMed ID: 9871511
[TBL] [Abstract][Full Text] [Related]
2. Peptidyl human heart chymase inhibitors. 2. Discovery of highly selective difluoromethylene ketone derivatives with Glu at P3 site.
Eda M; Ashimori A; Akahoshi F; Yoshimura T; Inoue Y; Fukaya C; Nakajima M; Fukuyama H; Imada T; Takai S; Shiota N; Miyazaki M; Nakamura N
Bioorg Med Chem Lett; 1998 Apr; 8(8):919-24. PubMed ID: 9871512
[TBL] [Abstract][Full Text] [Related]
3. Substituted 3-(phenylsulfonyl)-1-phenylimidazolidine-2,4-dione derivatives as novel nonpeptide inhibitors of human heart chymase.
Niwata S; Fukami H; Sumida M; Ito A; Kakutani S; Saitoh M; Suzuki K; Imoto M; Shibata H; Imajo S; Kiso Y; Tanaka T; Nakazato H; Ishihara T; Takai S; Yamamoto D; Shiota N; Miyazaki M; Okunishi H; Kinoshita A; Urata H; Arakawa K
J Med Chem; 1997 Jul; 40(14):2156-63. PubMed ID: 9216834
[TBL] [Abstract][Full Text] [Related]
4. Structure-activity relationship studies of chloromethyl ketone derivatives for selective human chymase inhibitors.
Hayashi Y; Iijima K; Katada J; Kiso Y
Bioorg Med Chem Lett; 2000 Feb; 10(3):199-201. PubMed ID: 10698435
[TBL] [Abstract][Full Text] [Related]
5. Non-peptidic inhibitors of human chymase. Synthesis, structure-activity relationships, and pharmacokinetic profiles of a series of 5-amino-6-oxo-1,6-dihydropyrimidine-containing trifluoromethyl ketones.
Akahoshi F; Ashimori A; Yoshimura T; Imada T; Nakajima M; Mitsutomi N; Kuwahara S; Ohtsuka T; Fukaya C; Miyazaki M; Nakamura N
Bioorg Med Chem; 2001 Feb; 9(2):301-15. PubMed ID: 11249123
[TBL] [Abstract][Full Text] [Related]
6. Potent, small-molecule inhibitors of human mast cell tryptase. Antiasthmatic action of a dipeptide-based transition-state analogue containing a benzothiazole ketone.
Costanzo MJ; Yabut SC; Almond HR; Andrade-Gordon P; Corcoran TW; De Garavilla L; Kauffman JA; Abraham WM; Recacha R; Chattopadhyay D; Maryanoff BE
J Med Chem; 2003 Aug; 46(18):3865-76. PubMed ID: 12930148
[TBL] [Abstract][Full Text] [Related]
7. Synthesis and structure-activity relationships of a new class of 1-oxacephem-based human chymase inhibitors.
Aoyama Y; Uenaka M; Konoike T; Iso Y; Nishitani Y; Kanda A; Naya N; Nakajima M
Bioorg Med Chem Lett; 2000 Nov; 10(21):2397-401. PubMed ID: 11078187
[TBL] [Abstract][Full Text] [Related]
8. 1-Oxacephem-based human chymase inhibitors: discovery of stable inhibitors in human plasma.
Aoyama Y; Uenaka M; Konoike T; Iso Y; Nishitani Y; Kanda A; Naya N; Nakajima M
Bioorg Med Chem Lett; 2000 Nov; 10(21):2403-6. PubMed ID: 11078188
[TBL] [Abstract][Full Text] [Related]
9. Potent inactivator of alpha-chymotrypsin: 2,2-dimethyl-3-(N-4-cyanobenzoyl)amino-5-phenyl pentanoic anhydride.
Ito K; Igarashi K; Muramatsu M; Harada T; Hayashi Y; Katada J; Uno I
Biochem Biophys Res Commun; 1997 Nov; 240(3):850-5. PubMed ID: 9398657
[TBL] [Abstract][Full Text] [Related]
10. Design and synthesis of indole and tetrahydroisoquinoline hydantoin derivatives as human chymase inhibitors.
Alagille D; Pfeiffer B; Scalbert E; Ferry G; Boutin JA; Renard P; Viaud-Massuard MC
J Enzyme Inhib Med Chem; 2004 Apr; 19(2):137-43. PubMed ID: 15449728
[TBL] [Abstract][Full Text] [Related]
11. Structure-activity studies of cyclic ketone inhibitors of the serine protease plasmin: design, synthesis, and biological activity.
Xue F; Seto CT
Bioorg Med Chem; 2006 Dec; 14(24):8467-87. PubMed ID: 16971130
[TBL] [Abstract][Full Text] [Related]
12. Synthesis, structure-activity relationships, and pharmacokinetic profiles of nonpeptidic difluoromethylene ketones as novel inhibitors of human chymase.
Akahoshi F; Ashimori A; Sakashita H; Yoshimura T; Eda M; Imada T; Nakajima M; Mitsutomi N; Kuwahara S; Ohtsuka T; Fukaya C; Miyazaki M; Nakamura N
J Med Chem; 2001 Apr; 44(8):1297-304. PubMed ID: 11312928
[TBL] [Abstract][Full Text] [Related]
13. Substituted 3-phenylsulfonylquinazoline-2,4-dione derivatives as novel nonpeptide inhibitors of human heart chymase.
Fukami H; Imajo S; Ito A; Kakutani S; Shibata H; Sumida M; Tanaka T; Niwata S; Saitoh M; Kiso Y; Miyazaki M; Okunishi H; Urata H; Arakawa K
Drug Des Discov; 2000; 17(1):69-84. PubMed ID: 10928450
[TBL] [Abstract][Full Text] [Related]
14. Nonpeptidic chymase inhibitors: design and structure-activity relationships of pyrimidinone derivatives based on the predicted binding mode of a peptidic inhibitor.
Akahoshi F
Curr Pharm Des; 2003; 9(15):1191-9. PubMed ID: 12769746
[TBL] [Abstract][Full Text] [Related]
15. Inhibition of human mast cell chymase by secretory leukocyte proteinase inhibitor: enhancement of the interaction by heparin.
Walter M; Plotnick M; Schechter NM
Arch Biochem Biophys; 1996 Mar; 327(1):81-8. PubMed ID: 8615699
[TBL] [Abstract][Full Text] [Related]
16. Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors.
Ghosh AK; Xi K; Ratia K; Santarsiero BD; Fu W; Harcourt BH; Rota PA; Baker SC; Johnson ME; Mesecar AD
J Med Chem; 2005 Nov; 48(22):6767-71. PubMed ID: 16250632
[TBL] [Abstract][Full Text] [Related]
17. Inhibitors of human heart chymase based on a peptide library.
Bastos M; Maeji NJ; Abeles RH
Proc Natl Acad Sci U S A; 1995 Jul; 92(15):6738-42. PubMed ID: 7624313
[TBL] [Abstract][Full Text] [Related]
18. Synthesis and kinetic studies of diphenyl 1-(N-peptidylamino)alkanephosphonate esters and their biotinylated derivatives as inhibitors of serine proteases and probes for lymphocyte granzymes.
Abuelyaman AS; Jackson DS; Hudig D; Woodard SL; Powers JC
Arch Biochem Biophys; 1997 Aug; 344(2):271-80. PubMed ID: 9264539
[TBL] [Abstract][Full Text] [Related]
19. Inactivation of chymotrypsin and human skin chymase: kinetics of time-dependent inhibition in the presence of substrate.
Johnson LA; Moon KE; Eisenberg M
Biochim Biophys Acta; 1988 Apr; 953(3):269-79. PubMed ID: 2451541
[TBL] [Abstract][Full Text] [Related]
20. Highly efficient and versatile synthesis of libraries of constrained beta-strand mimetics.
Ogbu CO; Qabar MN; Boatman PD; Urban J; Meara JP; Ferguson MD; Tulinsky J; Lum C; Babu S; Blaskovich MA; Nakanishi H; Ruan F; Cao B; Minarik R; Little T; Nelson S; Nguyen M; Gall A; Kahn M
Bioorg Med Chem Lett; 1998 Sep; 8(17):2321-6. PubMed ID: 9873535
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
