BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

133 related articles for article (PubMed ID: 9873607)

  • 1. The de novo design and synthesis of cyclic urea inhibitors of factor Xa: initial SAR studies.
    Galemmo RA; Maduskuie TP; Dominguez C; Rossi KA; Knabb RM; Wexler RR; Stouten PF
    Bioorg Med Chem Lett; 1998 Oct; 8(19):2705-10. PubMed ID: 9873607
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The de novo design and synthesis of cyclic urea inhibitors of factor Xa: optimization of the S4 ligand.
    Galemmo RA; Wells BL; Rossi KA; Alexander RS; Dominguez C; Maduskuie TP; Stouten PF; Wright MR; Aungst BJ; Wong PC; Knabb RM; Wexler RR
    Bioorg Med Chem Lett; 2000 Feb; 10(3):301-4. PubMed ID: 10698459
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Solid-phase optimisation of achiral amidinobenzyl indoles as potent and selective factor Xa inhibitors.
    Heinelt U; Herok S; Matter H; Wildgoose P
    Bioorg Med Chem Lett; 2001 Jan; 11(2):227-30. PubMed ID: 11206465
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, synthesis, and SAR of monobenzamidines and aminoisoquinolines as factor Xa inhibitors.
    Zhang P; Zuckett JF; Woolfrey J; Tran K; Huang B; Wong P; Sinha U; Park G; Reed A; Malinowski J; Hollenbach S; Scarborough RM; Zhu BY
    Bioorg Med Chem Lett; 2002 Jun; 12(12):1657-61. PubMed ID: 12039584
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Rational design and synthesis of novel, potent bis-phenylamidine carboxylate factor Xa inhibitors.
    Maduskuie TP; McNamara KJ; Ru Y; Knabb RM; Stouten PF
    J Med Chem; 1998 Jan; 41(1):53-62. PubMed ID: 9438022
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design, synthesis, and SAR of amino acid derivatives as factor Xa inhibitors.
    Su T; Wu Y; Doughan B; Jia ZJ; Woolfrey J; Huang B; Wong P; Park G; Sinha U; Scarborough RM; Zhu BY
    Bioorg Med Chem Lett; 2001 Nov; 11(22):2947-50. PubMed ID: 11677132
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design, synthesis, and structure-activity relationships of substituted piperazinone-based transition state factor Xa inhibitors.
    Su T; Yang H; Volkots D; Woolfrey J; Dam S; Wong P; Sinha U; Scarborough RM; Zhu BY
    Bioorg Med Chem Lett; 2003 Feb; 13(4):729-32. PubMed ID: 12639568
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Nonbenzamidine tetrazole derivatives as factor Xa inhibitors.
    Quan ML; Ellis CD; He MY; Liauw AY; Woerner FJ; Alexander RS; Knabb RM; Lam PY; Luettgen JM; Wong PC; Wright MR; Wexler RR
    Bioorg Med Chem Lett; 2003 Feb; 13(3):369-73. PubMed ID: 12565931
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Aminoisoquinolines: design and synthesis of an orally active benzamidine isostere for the inhibition of factor XA.
    Choi-Sledeski YM; Becker MR; Green DM; Davis R; Ewing WR; Mason HJ; Ly C; Spada A; Liang G; Cheney D; Barton J; Chu V; Brown K; Colussi D; Bentley R; Leadley R; Dunwiddie C; Pauls HW
    Bioorg Med Chem Lett; 1999 Sep; 9(17):2539-44. PubMed ID: 10498204
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Arylsulfonamidopiperidone derivatives as a novel class of factor Xa inhibitors.
    Shi Y; O'Connor SP; Sitkoff D; Zhang J; Shi M; Bisaha SN; Wang Y; Li C; Ruan Z; Lawrence RM; Klei HE; Kish K; Liu EC; Seiler SM; Schweizer L; Steinbacher TE; Schumacher WA; Robl JA; Macor JE; Atwal KS; Stein PD
    Bioorg Med Chem Lett; 2011 Dec; 21(24):7516-21. PubMed ID: 22041058
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Design and quantitative structure-activity relationship of 3-amidinobenzyl-1H-indole-2-carboxamides as potent, nonchiral, and selective inhibitors of blood coagulation factor Xa.
    Matter H; Defossa E; Heinelt U; Blohm PM; Schneider D; Müller A; Herok S; Schreuder H; Liesum A; Brachvogel V; Lönze P; Walser A; Al-Obeidi F; Wildgoose P
    J Med Chem; 2002 Jun; 45(13):2749-69. PubMed ID: 12061878
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Preparation of 1-(3-aminobenzo[d]isoxazol-5-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective, and efficacious inhibitors of coagulation factor Xa.
    Li YL; Fevig JM; Cacciola J; Buriak J; Rossi KA; Jona J; Knabb RM; Luettgen JM; Wong PC; Bai SA; Wexler RR; Lam PY
    Bioorg Med Chem Lett; 2006 Oct; 16(19):5176-82. PubMed ID: 16870435
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Halothiophene benzimidazoles as P1 surrogates of inhibitors of blood coagulation factor Xa.
    Mederski WW; Dorsch D; Anzali S; Gleitz J; Cezanne B; Tsaklakidis C
    Bioorg Med Chem Lett; 2004 Jul; 14(14):3763-9. PubMed ID: 15203158
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Novel, potent and selective chimeric FXa inhibitors featuring hydrophobic P1-ketoamide moieties.
    Semple JE; Levy OE; Minami NK; Owens TD; Siev DV
    Bioorg Med Chem Lett; 2000 Oct; 10(20):2305-9. PubMed ID: 11055344
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Design, synthesis, and biological activity of non-basic compounds as factor Xa inhibitors: SAR study of S1 and aryl binding sites.
    Komoriya S; Haginoya N; Kobayashi S; Nagata T; Mochizuki A; Suzuki M; Yoshino T; Horino H; Nagahara T; Suzuki M; Isobe Y; Furugoori T
    Bioorg Med Chem; 2005 Jun; 13(12):3927-54. PubMed ID: 15911309
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Amido-(propyl and allyl)-hydroxybenzamidines: development of achiral inhibitors of factor Xa.
    Gong Y; Pauls HW; Spada AP; Czekaj M; Liang G; Chu V; Colussi DJ; Brown KD; Gao J
    Bioorg Med Chem Lett; 2000 Feb; 10(3):217-21. PubMed ID: 10698439
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core.
    Fevig JM; Pinto DJ; Han Q; Quan ML; Pruitt JR; Jacobson IC; Galemmo RA; Wang S; Orwat MJ; Bostrom LL; Knabb RM; Wong PC; Lam PYS ; Wexler RR
    Bioorg Med Chem Lett; 2001 Mar; 11(5):641-5. PubMed ID: 11266160
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Design, synthesis and SAR of novel ethylenediamine and phenylenediamine derivatives as factor Xa inhibitors.
    Yoshikawa K; Yoshino T; Yokomizo Y; Uoto K; Naito H; Kawakami K; Mochizuki A; Nagata T; Suzuki M; Kanno H; Takemura M; Ohta T
    Bioorg Med Chem Lett; 2011 Apr; 21(7):2133-40. PubMed ID: 21345673
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design and synthesis of glycolic and mandelic acid derivatives as factor Xa inhibitors.
    Su T; Wu Y; Doughan B; Kane-Maguire K; Marlowe CK; Kanter JP; Woolfrey J; Huang B; Wong P; Sinha U; Park G; Malinowski J; Hollenbach S; Scarborough RM; Zhu BY
    Bioorg Med Chem Lett; 2001 Sep; 11(17):2279-82. PubMed ID: 11527714
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Design and synthesis of factor Xa inhibitors and their prodrugs.
    Song Y; Clizbe L; Bhakta C; Teng W; Wong P; Huang B; Tran K; Sinha U; Park G; Reed A; Scarborough RM; Zhu BY
    Bioorg Med Chem Lett; 2003 Jan; 13(2):297-300. PubMed ID: 12482444
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.