145 related articles for article (PubMed ID: 9876106)
1. Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition. 3. Synthesis and biological activities of oxazolecarboxamide-substituted omega-phenyl-omega-(3-pyridyl)alkenoic acid derivatives and related compounds.
Takeuchi K; Kohn TJ; True TA; Mais DE; Wikel JH; Utterback BG; Wyss VL; Jakubowski JA
J Med Chem; 1998 Dec; 41(27):5362-74. PubMed ID: 9876106
[TBL] [Abstract][Full Text] [Related]
2. Guanidine derivatives as combined thromboxane A2 receptor antagonists and synthase inhibitors.
Soyka R; Guth BD; Weisenberger HM; Luger P; Müller TH
J Med Chem; 1999 Apr; 42(7):1235-49. PubMed ID: 10197967
[TBL] [Abstract][Full Text] [Related]
3. Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition--I. Synthesis, structure-activity relationship, and evaluation of substituted omega-phenyl-omega-(3-pyridyl)alkenoic acids.
Takeuchi K; Happ AM; Mais DE; Layman N; Utterback BG; Wyss VL; Jakubowski JA
Bioorg Med Chem; 1994 Aug; 2(8):743-55. PubMed ID: 7894968
[TBL] [Abstract][Full Text] [Related]
4. Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition. 2. Design, synthesis, and evaluation of a novel series of phenyl oxazole derivatives.
Takeuchi K; Kohn TJ; Mais DE; True TA; Wyss VL; Jakubowski JA
Bioorg Med Chem Lett; 1998 Aug; 8(15):1943-8. PubMed ID: 9873463
[TBL] [Abstract][Full Text] [Related]
5. Thromboxane modulating agents. 3. 1H-imidazol-1-ylalkyl- and 3-pyridinylalkyl-substituted 3-[2-[(arylsulfonyl)amino]ethyl]benzenepropanoic acid derivatives as dual thromboxane synthase inhibitor/thromboxane receptor antagonists.
Dickinson RP; Dack KN; Long CJ; Steele J
J Med Chem; 1997 Oct; 40(21):3442-52. PubMed ID: 9341919
[TBL] [Abstract][Full Text] [Related]
6. In vitro and in vivo pharmacological characterization of BM-613 [N-n-pentyl-N'-[2-(4'-methylphenylamino)-5-nitrobenzenesulfonyl]urea], a novel dual thromboxane synthase inhibitor and thromboxane receptor antagonist.
Hanson J; Rolin S; Reynaud D; Qiao N; Kelley LP; Reid HM; Valentin F; Tippins J; Kinsella BT; Masereel B; Pace-Asciak C; Pirotte B; Dogné JM
J Pharmacol Exp Ther; 2005 Apr; 313(1):293-301. PubMed ID: 15626721
[TBL] [Abstract][Full Text] [Related]
7. Thromboxane synthase inhibitors suppress more effectively the aggregation of thromboxane receptor-desensitized than that of normal platelets: role of adenylylcyclase up-regulation.
Vezza R; Nenci GG; Gresele P
J Pharmacol Exp Ther; 1995 Dec; 275(3):1497-505. PubMed ID: 8531121
[TBL] [Abstract][Full Text] [Related]
8. Antiplatelet effect of a new inhibitor of thromboxane synthase and thromboxane A2 receptors.
Tubaro E; Belogi L; Mezzadri CM
Arzneimittelforschung; 1996 Jan; 46(1):35-41. PubMed ID: 8821515
[TBL] [Abstract][Full Text] [Related]
9. 6,6-Disubstituted Hex-5-enoic acid derivatives as combined thromboxane A2 receptor antagonists and synthetase inhibitors.
Soyka R; Heckel A; Nickl J; Eisert W; Müller TH; Weisenberger H
J Med Chem; 1994 Jan; 37(1):26-39. PubMed ID: 8289199
[TBL] [Abstract][Full Text] [Related]
10. Dual-acting thromboxane receptor antagonist/synthase inhibitors: synthesis and biological properties of [2-substituted-4-(3-pyridyl)-1,3-dioxan-5-yl] alkenoic acids.
Faull AW; Brewster AG; Brown GR; Smithers MJ; Jackson R
J Med Chem; 1995 Feb; 38(4):686-94. PubMed ID: 7861416
[TBL] [Abstract][Full Text] [Related]
11. Dibenzoxepin derivatives: thromboxane A2 synthase inhibition and thromboxane A2 receptor antagonism combined in one molecule.
Ohshima E; Sato H; Obase H; Miki I; Ishii A; Kawakage M; Shirakura S; Karasawa A; Kubo K
J Med Chem; 1993 May; 36(11):1613-8. PubMed ID: 8496929
[TBL] [Abstract][Full Text] [Related]
12. Synthesis of [[(benzenesulfonamido)alkyl]phenyl]alkanoic acid derivatives containing pyridyl or imidazolyl groups and their thromboxane A2 receptor antagonistic and thromboxane A2 synthase inhibitory activities.
Sakurai S; Ogawa N; Suzuki T; Kato K; Ohashi T; Yasuda S; Kato H
Chem Pharm Bull (Tokyo); 1996 Aug; 44(8):1510-20. PubMed ID: 8795270
[TBL] [Abstract][Full Text] [Related]
13. Development of dual-acting benzofurans for thromboxane A2 receptor antagonist and prostacyclin receptor agonist: synthesis, structure-activity relationship, and evaluation of benzofuran derivatives.
Ohno M; Miyamoto M; Hoshi K; Takeda T; Yamada N; Ohtake A
J Med Chem; 2005 Aug; 48(16):5279-94. PubMed ID: 16078846
[TBL] [Abstract][Full Text] [Related]
14. On the bioisosteric potential of diazines: diazine analogues of the combined thromboxane A2 receptor antagonist and synthetase inhibitor Ridogrel.
Heinisch G; Holzer W; Kunz F; Langer T; Lukavsky P; Pechlaner C; Weissenberger H
J Med Chem; 1996 Sep; 39(20):4058-64. PubMed ID: 8831771
[TBL] [Abstract][Full Text] [Related]
15. Pharmacological manipulation of the thromboxane pathway in blood platelets.
Hoet B; Deckmyn H; Arnout J; Vermylen J
Blood Coagul Fibrinolysis; 1990 Jun; 1(2):225-33. PubMed ID: 2130935
[TBL] [Abstract][Full Text] [Related]
16. An antithrombotic agent, NQ301, inhibits thromboxane A2 receptor and synthase activity in rabbit platelets.
Jin YR; Cho MR; Lee KS; Lee JJ; Lim Y; Han XH; Oh KW; Hong JT; Yoo HS; Yun YP
Basic Clin Pharmacol Toxicol; 2005 Sep; 97(3):162-7. PubMed ID: 16128910
[TBL] [Abstract][Full Text] [Related]
17. Interphenylene 7-oxabicyclo[2.2.1]heptane oxazoles. Highly potent, selective, and long-acting thromboxane A2 receptor antagonists.
Misra RN; Brown BR; Sher PM; Patel MM; Hall SE; Han WC; Barrish JC; Kocy O; Harris DN; Goldenberg HJ
J Med Chem; 1993 May; 36(10):1401-17. PubMed ID: 8496908
[TBL] [Abstract][Full Text] [Related]
18. A novel pyridobenzazepinone derivative with long lasting thromboxane synthase inhibition.
Miki I; Kishibayashi N; Takeda M; Suzuki K; Obase H; Ishii A
Arzneimittelforschung; 1995 Oct; 45(10):1066-70. PubMed ID: 8595060
[TBL] [Abstract][Full Text] [Related]
19. Terbogrel, a dual-acting agent for thromboxane receptor antagonism and thromboxane synthase inhibition.
Michaux C; Norberg B; Dogné JM; Durant F; Masereel B; Delarge J; Wouters J
Acta Crystallogr C; 2000 Oct; 56 ( Pt 10)():1265-6. PubMed ID: 11025320
[TBL] [Abstract][Full Text] [Related]
20. Effect of BM-573 [N-terbutyl-N'-[2-(4'-methylphenylamino)-5-nitro-benzenesulfonyl]urea], a dual thromboxane synthase inhibitor and thromboxane receptor antagonist, in a porcine model of acute pulmonary embolism.
Ghuysen A; Lambermont B; Dogné JM; Kolh P; Tchana-Sato V; Morimont P; Magis D; Hanson J; Segers P; D'Orio V
J Pharmacol Exp Ther; 2004 Sep; 310(3):964-72. PubMed ID: 15121765
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]