340 related articles for article (PubMed ID: 9876114)
1. Structural and functional analyses of benzamidine-based inhibitors in complex with trypsin: implications for the inhibition of factor Xa, tPA, and urokinase.
Renatus M; Bode W; Huber R; Stürzebecher J; Stubbs MT
J Med Chem; 1998 Dec; 41(27):5445-56. PubMed ID: 9876114
[TBL] [Abstract][Full Text] [Related]
2. Urethanyl-3-amidinophenylalanine derivatives as inhibitors of factor Xa. X-ray crystal structure of a trypsin/inhibitor complex and modeling studies.
Sperl S; Bergner A; Stürzebecher J; Magdolen V; Bode W; Moroder L
Biol Chem; 2000 Apr; 381(4):321-9. PubMed ID: 10839461
[TBL] [Abstract][Full Text] [Related]
3. A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
Katz BA; Elrod K; Luong C; Rice MJ; Mackman RL; Sprengeler PA; Spencer J; Hataye J; Janc J; Link J; Litvak J; Rai R; Rice K; Sideris S; Verner E; Young W
J Mol Biol; 2001 Apr; 307(5):1451-86. PubMed ID: 11292354
[TBL] [Abstract][Full Text] [Related]
4. In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.
Costanzo MJ; Almond HR; Hecker LR; Schott MR; Yabut SC; Zhang HC; Andrade-Gordon P; Corcoran TW; Giardino EC; Kauffman JA; Lewis JM; de Garavilla L; Haertlein BJ; Maryanoff BE
J Med Chem; 2005 Mar; 48(6):1984-2008. PubMed ID: 15771442
[TBL] [Abstract][Full Text] [Related]
5. Understanding binding selectivity toward trypsin and factor Xa: the role of aromatic interactions.
Di Fenza A; Heine A; Koert U; Klebe G
ChemMedChem; 2007 Mar; 2(3):297-308. PubMed ID: 17191291
[TBL] [Abstract][Full Text] [Related]
6. X-ray crystallographic analyses of complexes between bovine beta-trypsin and Schiff base copper(II) or iron(III) chelates.
Toyota E; Ng KK; Sekizaki H; Itoh K; Tanizawa K; James MN
J Mol Biol; 2001 Jan; 305(3):471-9. PubMed ID: 11152605
[TBL] [Abstract][Full Text] [Related]
7. Design of benzamidine-type inhibitors of factor Xa.
Gabriel B; Stubbs MT; Bergner A; Hauptmann J; Bode W; Stürzebecher J; Moroder L
J Med Chem; 1998 Oct; 41(22):4240-50. PubMed ID: 9784099
[TBL] [Abstract][Full Text] [Related]
8. Inhibition of bovine beta-trypsin, human alpha-thrombin and porcine pancreatic beta-kallikrein-B by benzamidine and its bis-, tris- and tetra-derivatives: thermodynamic and molecular modeling study.
Menegatti E; Ferroni R; Nastruzzi C; Bortolotti F; Scalia S; Amiconi G; Bolognesi M; Coletta M; Onesti S; Fruttero R
Farmaco; 1991 Nov; 46(11):1297-310. PubMed ID: 1811616
[TBL] [Abstract][Full Text] [Related]
9. The second Kunitz domain of human tissue factor pathway inhibitor: cloning, structure determination and interaction with factor Xa.
Burgering MJ; Orbons LP; van der Doelen A; Mulders J; Theunissen HJ; Grootenhuis PD; Bode W; Huber R; Stubbs MT
J Mol Biol; 1997 Jun; 269(3):395-407. PubMed ID: 9199408
[TBL] [Abstract][Full Text] [Related]
10. 3D-QSAR CoMFA studies on trypsin-like serine protease inhibitors: a comparative selectivity analysis.
Bhongade BA; Gouripur VV; Gadad AK
Bioorg Med Chem; 2005 Apr; 13(8):2773-82. PubMed ID: 15781388
[TBL] [Abstract][Full Text] [Related]
11. Molecular basis of specific inhibition of urokinase plasminogen activator by amiloride.
Jankun J; Skrzypczak-Jankun E
Cancer Biochem Biophys; 1999 Jul; 17(1-2):109-23. PubMed ID: 10738907
[TBL] [Abstract][Full Text] [Related]
12. Design, synthesis, and activity of 2,6-diphenoxypyridine-derived factor Xa inhibitors.
Phillips G; Davey DD; Eagen KA; Koovakkat SK; Liang A; Ng HP; Pinkerton M; Trinh L; Whitlow M; Beatty AM; Morrissey MM
J Med Chem; 1999 May; 42(10):1749-56. PubMed ID: 10346927
[TBL] [Abstract][Full Text] [Related]
13. The cowpox virus serpin SPI-3 complexes with and inhibits urokinase-type and tissue-type plasminogen activators and plasmin.
Turner PC; Baquero MT; Yuan S; Thoennes SR; Moyer RW
Virology; 2000 Jul; 272(2):267-80. PubMed ID: 10873770
[TBL] [Abstract][Full Text] [Related]
14. Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.
Katz BA; Mackman R; Luong C; Radika K; Martelli A; Sprengeler PA; Wang J; Chan H; Wong L
Chem Biol; 2000 Apr; 7(4):299-312. PubMed ID: 10779411
[TBL] [Abstract][Full Text] [Related]
15. Comparative molecular modeling analysis of-5-amidinoindole and benzamidine binding to thrombin and trypsin: specific H-bond formation contributes to high 5-amidinoindole potency and selectivity for thrombin and factor Xa.
Zhou Y; Johnson ME
J Mol Recognit; 1999; 12(4):235-41. PubMed ID: 10440994
[TBL] [Abstract][Full Text] [Related]
16. Lysine 156 promotes the anomalous proenzyme activity of tPA: X-ray crystal structure of single-chain human tPA.
Renatus M; Engh RA; Stubbs MT; Huber R; Fischer S; Kohnert U; Bode W
EMBO J; 1997 Aug; 16(16):4797-805. PubMed ID: 9305622
[TBL] [Abstract][Full Text] [Related]
17. The crystal structures of 3-TAPAP in complexes with the urokinase-type plasminogen activator and picrate.
Zesławska E; Jacob U; Stürzebecher J; Oleksyn BJ
Bioorg Med Chem Lett; 2006 Jan; 16(1):228-34. PubMed ID: 16202591
[TBL] [Abstract][Full Text] [Related]
18. Three-dimensional quantitative structure-activity relationship analyses using comparative molecular field analysis and comparative molecular similarity indices analysis to elucidate selectivity differences of inhibitors binding to trypsin, thrombin, and factor Xa.
Böhm M; St rzebecher J; Klebe G
J Med Chem; 1999 Feb; 42(3):458-77. PubMed ID: 9986717
[TBL] [Abstract][Full Text] [Related]
19. Engineering bidentate macromolecular inhibitors for trypsin and urokinase-type plasminogen activator.
Yang SQ; Craik CS
J Mol Biol; 1998 Jun; 279(4):1001-11. PubMed ID: 9642077
[TBL] [Abstract][Full Text] [Related]
20. Structural binding evidence of the trypanocidal drugs berenil and pentacarinate active principles to a serine protease model.
Perilo CS; Pereira MT; Santoro MM; Nagem RA
Int J Biol Macromol; 2010 Jun; 46(5):502-11. PubMed ID: 20356563
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
