BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

181 related articles for article (PubMed ID: 9878382)

  • 1. Mutations of Gly to Ala in human glutathione transferase P1-1 affect helix 2 (G-site) and induce positive cooperativity in the binding of glutathione.
    Lo Bello M; Nuccetelli M; Chiessi E; Lahm A; Mazzetti AP; Battistoni A; Caccuri AM; Oakley AJ; Parker MW; Tramontano A; Federici G; Ricci G
    J Mol Biol; 1998 Dec; 284(5):1717-25. PubMed ID: 9878382
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Engineering a new C-terminal tail in the H-site of human glutathione transferase P1-1: structural and functional consequences.
    Micaloni C; Kong GK; Mazzetti AP; Nuccetelli M; Antonini G; Stella L; McKinstry WJ; Polekhina G; Rossjohn J; Federici G; Ricci G; Parker MW; Lo Bello M
    J Mol Biol; 2003 Jan; 325(1):111-22. PubMed ID: 12473455
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Site-directed mutagenesis of amino acid residues involved in the glutathione binding of human glutathione S-transferase P1-1.
    Kong KH; Inoue H; Takahashi K
    J Biochem; 1992 Dec; 112(6):725-8. PubMed ID: 1295879
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Rat glutathione S-transferase M4-4: an isoenzyme with unique structural features including a redox-reactive cysteine-115 residue that forms mixed disulphides with glutathione.
    Cheng H; Tchaikovskaya T; Tu YS; Chapman J; Qian B; Ching WM; Tien M; Rowe JD; Patskovsky YV; Listowsky I; Tu CP
    Biochem J; 2001 Jun; 356(Pt 2):403-14. PubMed ID: 11368767
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Valine 10 may act as a driver for product release from the active site of human glutathione transferase P1-1.
    Micaloni C; Mazzetti AP; Nuccetelli M; Rossjohn J; McKinstry WJ; Antonini G; Caccuri AM; Oakley AJ; Federici G; Ricci G; Parker MW; Lo Bello M
    Biochemistry; 2000 Dec; 39(51):15961-70. PubMed ID: 11123923
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structural flexibility modulates the activity of human glutathione transferase P1-1. Role of helix 2 flexibility in the catalytic mechanism.
    Ricci G; Caccuri AM; Lo Bello M; Rosato N; Mei G; Nicotra M; Chiessi E; Mazzetti AP; Federici G
    J Biol Chem; 1996 Jul; 271(27):16187-92. PubMed ID: 8663072
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Effects of directed mutagenesis on conserved arginine residues in a human Class Alpha glutathione transferase.
    Stenberg G; Board PG; Carlberg I; Mannervik B
    Biochem J; 1991 Mar; 274 ( Pt 2)(Pt 2):549-55. PubMed ID: 2006917
    [TBL] [Abstract][Full Text] [Related]  

  • 8. A conserved N-capping motif contributes significantly to the stabilization and dynamics of the C-terminal region of class Alpha glutathione S-transferases.
    Dirr HW; Little T; Kuhnert DC; Sayed Y
    J Biol Chem; 2005 May; 280(20):19480-7. PubMed ID: 15757902
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Site-directed mutagenesis of human glutathione transferase P1-1. Mutation of Cys-47 induces a positive cooperativity in glutathione transferase P1-1.
    Ricci G; Lo Bello M; Caccurri AM; Pastore A; Nuccetelli M; Parker MW; Federici G
    J Biol Chem; 1995 Jan; 270(3):1243-8. PubMed ID: 7836386
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structural flexibility modulates the activity of human glutathione transferase P1-1. Influence of a poor co-substrate on dynamics and kinetics of human glutathione transferase.
    Caccuri AM; Ascenzi P; Antonini G; Parker MW; Oakley AJ; Chiessi E; Nuccetelli M; Battistoni A; Bellizia A; Ricci G
    J Biol Chem; 1996 Jul; 271(27):16193-8. PubMed ID: 8663073
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Characterization of chicken-liver glutathione S-transferase (GST) A1-1 and A2-2 isoenzymes and their site-directed mutants heterologously expressed in Escherichia coli: identification of Lys-15 and Ser-208 on cGSTA1-1 as residues interacting with ethacrynic acid.
    Liu LF; Liaw YC; Tam MF
    Biochem J; 1997 Oct; 327 ( Pt 2)(Pt 2):593-600. PubMed ID: 9359434
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Tyr115, gln165 and trp209 contribute to the 1, 2-epoxy-3-(p-nitrophenoxy)propane-conjugating activity of glutathione S-transferase cGSTM1-1.
    Chern MK; Wu TC; Hsieh CH; Chou CC; Liu LF; Kuan IC; Yeh YH; Hsiao CD; Tam MF
    J Mol Biol; 2000 Jul; 300(5):1257-69. PubMed ID: 10903867
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Multifunctional role of Tyr 108 in the catalytic mechanism of human glutathione transferase P1-1. Crystallographic and kinetic studies on the Y108F mutant enzyme.
    Lo Bello M; Oakley AJ; Battistoni A; Mazzetti AP; Nuccetelli M; Mazzarese G; Rossjohn J; Parker MW; Ricci G
    Biochemistry; 1997 May; 36(20):6207-17. PubMed ID: 9166793
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Design of a monomeric human glutathione transferase GSTP1, a structurally stable but catalytically inactive protein.
    Abdalla AM; Bruns CM; Tainer JA; Mannervik B; Stenberg G
    Protein Eng; 2002 Oct; 15(10):827-34. PubMed ID: 12468717
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Site-directed mutagenesis of human glutathione transferase P1-1. Spectral, kinetic, and structural properties of Cys-47 and Lys-54 mutants.
    Lo Bello M; Battistoni A; Mazzetti AP; Board PG; Muramatsu M; Federici G; Ricci G
    J Biol Chem; 1995 Jan; 270(3):1249-53. PubMed ID: 7836387
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Molecular dynamics simulations of human glutathione transferase P1-1: analysis of the induced-fit mechanism by GSH binding.
    Stella L; Nicotra M; Ricci G; Rosato N; Di Iorio EE
    Proteins; 1999 Oct; 37(1):1-9. PubMed ID: 10451545
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The C-terminal region of human glutathione transferase A1-1 affects the rate of glutathione binding and the ionization of the active-site Tyr9.
    Gustafsson A; Etahadieh M; Jemth P; Mannervik B
    Biochemistry; 1999 Dec; 38(49):16268-75. PubMed ID: 10587450
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Stability of the domain interface contributes towards the catalytic function at the H-site of class alpha glutathione transferase A1-1.
    Balchin D; Fanucchi S; Achilonu I; Adamson RJ; Burke J; Fernandes M; Gildenhuys S; Dirr HW
    Biochim Biophys Acta; 2010 Dec; 1804(12):2228-33. PubMed ID: 20833278
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Flexibility of helix 2 in the human glutathione transferase P1-1. time-resolved fluorescence spectroscopy.
    Stella L; Caccuri AM; Rosato N; Nicotra M; Lo Bello M; De Matteis F; Mazzetti AP; Federici G; Ricci G
    J Biol Chem; 1998 Sep; 273(36):23267-73. PubMed ID: 9722558
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Active site architecture of polymorphic forms of human glutathione S-transferase P1-1 accounts for their enantioselectivity and disparate activity in the glutathione conjugation of 7beta,8alpha-dihydroxy-9alpha,10alpha-ox y-7,8,9,10-tetrahydrobenzo(a)pyrene.
    Hu X; O'Donnell R; Srivastava SK; Xia H; Zimniak P; Nanduri B; Bleicher RJ; Awasthi S; Awasthi YC; Ji X; Singh SV
    Biochem Biophys Res Commun; 1997 Jun; 235(2):424-8. PubMed ID: 9199210
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.