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2. Crystal structure of a deletion mutant of human thymidylate synthase Delta (7-29) and its ternary complex with Tomudex and dUMP. Almog R; Waddling CA; Maley F; Maley GF; Van Roey P Protein Sci; 2001 May; 10(5):988-96. PubMed ID: 11316879 [TBL] [Abstract][Full Text] [Related]
3. Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug. Phan J; Koli S; Minor W; Dunlap RB; Berger SH; Lebioda L Biochemistry; 2001 Feb; 40(7):1897-902. PubMed ID: 11329255 [TBL] [Abstract][Full Text] [Related]
4. Partitioning roles of side chains in affinity, orientation, and catalysis with structures for mutant complexes: asparagine-229 in thymidylate synthase. Finer-Moore JS; Liu L; Schafmeister CE; Birdsall DL; Mau T; Santi DV; Stroud RM Biochemistry; 1996 Apr; 35(16):5125-36. PubMed ID: 8611496 [TBL] [Abstract][Full Text] [Related]
5. Structure-based design of lipophilic quinazoline inhibitors of thymidylate synthase. Jones TR; Varney MD; Webber SE; Lewis KK; Marzoni GP; Palmer CL; Kathardekar V; Welsh KM; Webber S; Matthews DA; Appelt K; Smith WW; Janson CA; Villafranca JE; Bacquet RJ; Howland EF; Booth CL; Herrmann SM; Ward RW; White J; Moomaw EW; Bartlett CA; Morse CA J Med Chem; 1996 Feb; 39(4):904-17. PubMed ID: 8632414 [TBL] [Abstract][Full Text] [Related]
6. Binding of the anticancer drug ZD1694 to E. coli thymidylate synthase: assessing specificity and affinity. Rutenber EE; Stroud RM Structure; 1996 Nov; 4(11):1317-24. PubMed ID: 8939755 [TBL] [Abstract][Full Text] [Related]
7. Use of strain in a stereospecific catalytic mechanism: crystal structures of Escherichia coli thymidylate synthase bound to FdUMP and methylenetetrahydrofolate. Hyatt DC; Maley F; Montfort WR Biochemistry; 1997 Apr; 36(15):4585-94. PubMed ID: 9109668 [TBL] [Abstract][Full Text] [Related]
8. Crystal structures of thymidylate synthase mutant R166Q: structural basis for the nearly complete loss of catalytic activity. Sotelo-Mundo RR; Changchien L; Maley F; Montfort WR J Biochem Mol Toxicol; 2006; 20(2):88-92. PubMed ID: 16615077 [TBL] [Abstract][Full Text] [Related]
9. Multi-targeted antifolates aimed at avoiding drug resistance form covalent closed inhibitory complexes with human and Escherichia coli thymidylate synthases. Sayre PH; Finer-Moore JS; Fritz TA; Biermann D; Gates SB; MacKellar WC; Patel VF; Stroud RM J Mol Biol; 2001 Nov; 313(4):813-29. PubMed ID: 11697906 [TBL] [Abstract][Full Text] [Related]
10. Drug-resistant variants of Escherichia coli thymidylate synthase: effects of substitutions at Pro-254. Fantz C; Shaw D; Jennings W; Forsthoefel A; Kitchens M; Phan J; Minor W; Lebioda L; Berger FG; Spencer HT Mol Pharmacol; 2000 Feb; 57(2):359-66. PubMed ID: 10648646 [TBL] [Abstract][Full Text] [Related]
11. D221 in thymidylate synthase controls conformation change, and thereby opening of the imidazolidine. Sage CR; Michelitsch MD; Stout TJ; Biermann D; Nissen R; Finer-Moore J; Stroud RM Biochemistry; 1998 Sep; 37(39):13893-901. PubMed ID: 9753479 [TBL] [Abstract][Full Text] [Related]
12. The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition. Finer-Moore JS; Anderson AC; O'Neil RH; Costi MP; Ferrari S; Krucinski J; Stroud RM Acta Crystallogr D Biol Crystallogr; 2005 Oct; 61(Pt 10):1320-34. PubMed ID: 16204883 [TBL] [Abstract][Full Text] [Related]
13. An essential role for water in an enzyme reaction mechanism: the crystal structure of the thymidylate synthase mutant E58Q. Sage CR; Rutenber EE; Stout TJ; Stroud RM Biochemistry; 1996 Dec; 35(50):16270-81. PubMed ID: 8973201 [TBL] [Abstract][Full Text] [Related]
14. The crystal structure of thymidylate synthase from Pneumocystis carinii reveals a fungal insert important for drug design. Anderson AC; Perry KM; Freymann DM; Stroud RM J Mol Biol; 2000 Mar; 297(3):645-57. PubMed ID: 10731418 [TBL] [Abstract][Full Text] [Related]
15. Immunoreactive dUMP and TTP pools as an index of thymidylate synthase inhibition; effect of tomudex (ZD1694) and a nonpolyglutamated quinazoline antifolate (CB30900) in L1210 mouse leukaemia cells. Aherne GW; Hardcastle A; Raynaud F; Jackman AL Biochem Pharmacol; 1996 May; 51(10):1293-301. PubMed ID: 8787544 [TBL] [Abstract][Full Text] [Related]
16. The effect of 5-substitution in the pyrimidine ring of dUMP on the interaction with thymidylate synthase: molecular modeling and QSAR. Jarmuła A; Cieplak P; Krygowski TM; Rode W Bioorg Med Chem; 2007 Mar; 15(6):2346-58. PubMed ID: 17275316 [TBL] [Abstract][Full Text] [Related]
17. Thermodynamic stabilization of nucleotide binding to thymidylate synthase by a potent benzoquinazoline folate analogue inhibitor. Chen CH; Davis RA; Maley F Biochemistry; 1996 Jul; 35(26):8786-93. PubMed ID: 8679643 [TBL] [Abstract][Full Text] [Related]
18. Kinetic scheme for thymidylate synthase from Escherichia coli: determination from measurements of ligand binding, primary and secondary isotope effects, and pre-steady-state catalysis. Spencer HT; Villafranca JE; Appleman JR Biochemistry; 1997 Apr; 36(14):4212-22. PubMed ID: 9100016 [TBL] [Abstract][Full Text] [Related]
19. Structure-based design of substituted diphenyl sulfones and sulfoxides as lipophilic inhibitors of thymidylate synthase. Jones TR; Webber SE; Varney MD; Reddy MR; Lewis KK; Kathardekar V; Mazdiyasni H; Deal J; Nguyen D; Welsh KM; Webber S; Johnston A; Matthews DA; Smith WW; Janson CA; Bacquet RJ; Howland EF; Booth CL; Herrmann SM; Ward RW; White J; Bartlett CA; Morse CA J Med Chem; 1997 Feb; 40(5):677-83. PubMed ID: 9057854 [TBL] [Abstract][Full Text] [Related]
20. Structural aspects of the inhibition and catalytic mechanism of thymidylate synthase. Hardy LW Acta Biochim Pol; 1995; 42(4):367-80. PubMed ID: 8852328 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]