BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

212 related articles for article (PubMed ID: 9934863)

  • 1. Alpha-hydroxytamoxifen, a genotoxic metabolite of tamoxifen in the rat: identification and quantification in vivo and in vitro.
    Boocock DJ; Maggs JL; White IN; Park BK
    Carcinogenesis; 1999 Jan; 20(1):153-60. PubMed ID: 9934863
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Major inter-species differences in the rates of O-sulphonation and O-glucuronylation of alpha-hydroxytamoxifen in vitro: a metabolic disparity protecting human liver from the formation of tamoxifen-DNA adducts.
    Boocock DJ; Maggs JL; Brown K; White IN; Park BK
    Carcinogenesis; 2000 Oct; 21(10):1851-8. PubMed ID: 11023543
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Characterization of the human cytochrome P450 forms involved in metabolism of tamoxifen to its alpha-hydroxy and alpha,4-dihydroxy derivatives.
    Notley LM; Crewe KH; Taylor PJ; Lennard MS; Gillam EM
    Chem Res Toxicol; 2005 Oct; 18(10):1611-8. PubMed ID: 16533026
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Induction of CYP2B1 and 3A1, and associated monoxygenase activities by tamoxifen and certain analogues in the livers of female rats and mice.
    White IN; Davies A; Smith LL; Dawson S; De Matteis F
    Biochem Pharmacol; 1993 Jan; 45(1):21-30. PubMed ID: 8424814
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Potential beneficial metabolic interactions between tamoxifen and isoflavones via cytochrome P450-mediated pathways in female rat liver microsomes.
    Chen J; Halls SC; Alfaro JF; Zhou Z; Hu M
    Pharm Res; 2004 Nov; 21(11):2095-104. PubMed ID: 15587933
    [TBL] [Abstract][Full Text] [Related]  

  • 6. 4-Hydroxylated metabolites of the antiestrogens tamoxifen and toremifene are metabolized to unusually stable quinone methides.
    Fan PW; Zhang F; Bolton JL
    Chem Res Toxicol; 2000 Jan; 13(1):45-52. PubMed ID: 10649966
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Bioactivation of the cancer chemopreventive agent tamoxifen to quinone methides by cytochrome P4502B6 and identification of the modified residue on the apoprotein.
    Sridar C; D'Agostino J; Hollenberg PF
    Drug Metab Dispos; 2012 Dec; 40(12):2280-8. PubMed ID: 22942317
    [TBL] [Abstract][Full Text] [Related]  

  • 8. In vitro metabolism of tirilazad mesylate in male and female rats. Contribution of cytochrome P4502C11 and delta 4-5 alpha-reductase.
    Wienkers LC; Steenwyk RC; Mizsak SA; Pearson PG
    Drug Metab Dispos; 1995 Mar; 23(3):383-92. PubMed ID: 7628305
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Cytochrome P-450 3A and 2D6 catalyze ortho hydroxylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: involvement of catechols in covalent binding to hepatic proteins.
    Dehal SS; Kupfer D
    Drug Metab Dispos; 1999 Jun; 27(6):681-8. PubMed ID: 10348797
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Rat and human liver cytochrome P-450 isoform metabolism of ecteinascidin 743 does not predict gender-dependent toxicity in humans.
    Reid JM; Kuffel MJ; Ruben SL; Morales JJ; Rinehart KL; Squillace DP; Ames MM
    Clin Cancer Res; 2002 Sep; 8(9):2952-62. PubMed ID: 12231541
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Effect of N,N-didesmethyltamoxifen upon DNA adduct formation by tamoxifen and alpha-hydroxytamoxifen.
    Gamboa da Costa G; Marques MM; Fu X; Churchwell MI; Wang YP; Doerge DR; Beland FA
    Cancer Lett; 2007 Nov; 257(2):191-8. PubMed ID: 17765393
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Induction of tamoxifen-4-hydroxylation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), beta-naphthoflavone (beta NF), and phenobarbital (PB) in avian liver: identification of P450 TCDDAA as catalyst of 4-hydroxylation induced by TCDD and beta NF.
    Kupfer D; Mani C; Lee CA; Rifkind AB
    Cancer Res; 1994 Jun; 54(12):3140-4. PubMed ID: 8205532
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Inhibition and kinetics of cytochrome P4503A activity in microsomes from rat, human, and cdna-expressed human cytochrome P450.
    Ghosal A; Satoh H; Thomas PE; Bush E; Moore D
    Drug Metab Dispos; 1996 Sep; 24(9):940-7. PubMed ID: 8886602
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Reversible and irreversible inhibition of CYP3A enzymes by tamoxifen and metabolites.
    Zhao XJ; Jones DR; Wang YH; Grimm SW; Hall SD
    Xenobiotica; 2002 Oct; 32(10):863-78. PubMed ID: 12419016
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Evidence for involvement of human CYP3A in the 3-hydroxylation of quinine.
    Zhang H; Coville PF; Walker RJ; Miners JO; Birkett DJ; Wanwimolruk S
    Br J Clin Pharmacol; 1997 Mar; 43(3):245-52. PubMed ID: 9088578
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Comparison of the DNA adducts formed by tamoxifen and 4-hydroxytamoxifen in vivo.
    Beland FA; McDaniel LP; Marques MM
    Carcinogenesis; 1999 Mar; 20(3):471-7. PubMed ID: 10190564
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Species differences in stereoselective metabolism of mephenytoin by cytochrome P450 (CYP2C and CYP3A).
    Yasumori T; Chen L; Nagata K; Yamazoe Y; Kato R
    J Pharmacol Exp Ther; 1993 Jan; 264(1):89-94. PubMed ID: 8423554
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Interindividual variation in the isomerization of 4-hydroxytamoxifen by human liver microsomes: involvement of cytochromes P450.
    Williams ML; Lennard MS; Martin IJ; Tucker GT
    Carcinogenesis; 1994 Dec; 15(12):2733-8. PubMed ID: 8001229
    [TBL] [Abstract][Full Text] [Related]  

  • 19. DNA adduct formation and mutant induction in Sprague-Dawley rats treated with tamoxifen and its derivatives.
    Gamboa da Costa G; McDaniel-Hamilton LP; Heflich RH; Marques MM; Beland FA
    Carcinogenesis; 2001 Aug; 22(8):1307-15. PubMed ID: 11470763
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The effect of dose and cytochrome P450 induction on the metabolism and disposition of the food-borne carcinogen 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline (MeIQx) in the rat.
    Turesky RJ; Markovic J; Bracco-Hammer I; Fay LB
    Carcinogenesis; 1991 Oct; 12(10):1847-55. PubMed ID: 1934266
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.