BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

226 related articles for article (PubMed ID: 9950274)

  • 21. Factors that restrict intestinal cell permeation of cyclic prodrugs of an opioid peptide (DADLE): Part II. Role of metabolic enzymes in the intestinal mucosa.
    Ouyang H; Chen W; Andersen TE; Steffansen B; Borchardt RT
    J Pharm Sci; 2009 Jan; 98(1):349-61. PubMed ID: 18537150
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Chemical and enzymatic stability as well as transport properties of a Leu-enkephalin analogue and ester prodrugs thereof.
    Fredholt K; Adrian C; Just L; Hoj Larsen D; Weng S; Moss B; Juel Friis G
    J Control Release; 2000 Feb; 63(3):261-73. PubMed ID: 10601722
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Factors that restrict the cell permeation of cyclic prodrugs of an opioid peptide, part 3: Synthesis of analogs designed to have improved stability to oxidative metabolism.
    Nofsinger R; Fuchs-Knotts T; Borchardt RT
    J Pharm Sci; 2012 Sep; 101(9):3486-99. PubMed ID: 22411763
    [TBL] [Abstract][Full Text] [Related]  

  • 24. The effect of conformation on the membrane permeation of coumarinic acid- and phenylpropionic acid-based cyclic prodrugs of opioid peptides.
    Gudmundsson OS; Jois SD; Vander Velde DG; Siahaan TJ; Wang B; Borchardt RT
    J Pept Res; 1999 Apr; 53(4):383-92. PubMed ID: 10406216
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Factors that restrict the cell permeation of cyclic prodrugs of an opioid peptide, part 4: Characterization of the biopharmaceutical and physicochemical properties of two new cyclic prodrugs designed to be stable to oxidative metabolism by cytochrome P-450 enzymes in the intestinal mucosa.
    Nofsinger R; Borchardt RT
    J Pharm Sci; 2012 Sep; 101(9):3500-10. PubMed ID: 22337204
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Synthesis and evaluation of novel coumarin-based esterase-sensitive cyclic prodrugs of peptidomimetic RGD analogs with improved membrane permeability.
    Wang B; Wang W; Camenisch GP; Elmo J; Zhang H; Borchardt RT
    Chem Pharm Bull (Tokyo); 1999 Jan; 47(1):90-5. PubMed ID: 9987829
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Transport characteristics of peptidomimetics. Effect of the pyrrolinone bioisostere on transport across Caco-2 cell monolayers.
    Sudoh M; Pauletti GM; Yao W; Moser W; Yokoyama A; Pasternak A; Sprengeler PA; Smith AB; Hirschmann R; Borchardt RT
    Pharm Res; 1998 May; 15(5):719-25. PubMed ID: 9619780
    [TBL] [Abstract][Full Text] [Related]  

  • 28. A comparison of the effects of p-glycoprotein inhibitors on the blood-brain barrier permeation of cyclic prodrugs of an opioid peptide (DADLE).
    Ouyang H; Andersen TE; Chen W; Nofsinger R; Steffansen B; Borchardt RT
    J Pharm Sci; 2009 Jun; 98(6):2227-36. PubMed ID: 18855917
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Increasing oral absorption of polar neuraminidase inhibitors: a prodrug transporter approach applied to oseltamivir analogue.
    Gupta D; Varghese Gupta S; Dahan A; Tsume Y; Hilfinger J; Lee KD; Amidon GL
    Mol Pharm; 2013 Feb; 10(2):512-22. PubMed ID: 23244438
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Prodrug approach for alphaIIbbeta3-peptidomimetic antagonists to enhance their transport in monolayers of a human intestinal cell line (Caco-2): comparison of in vitro and in vivo data.
    Kamm W; Raddatz P; Gante J; Kissel T
    Pharm Res; 1999 Oct; 16(10):1527-33. PubMed ID: 10554093
    [TBL] [Abstract][Full Text] [Related]  

  • 31. The effect of beta-turn structure on the passive diffusion of peptides across Caco-2 cell monolayers.
    Knipp GT; Vander Velde DG; Siahaan TJ; Borchardt RT
    Pharm Res; 1997 Oct; 14(10):1332-40. PubMed ID: 9358544
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Syntheses of cyclic prodrugs of RGD peptidomimetics with various macrocyclic ring sizes: evaluation of physicochemical, transport and antithrombic properties.
    He HT; Xu CR; Song X; Siahaan TJ
    J Pept Res; 2003 Jun; 61(6):331-42. PubMed ID: 12753380
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Synthesis of a novel cyclic prodrug of RGD peptidomimetic to improve its cell membrane permeation.
    Song X; Xu CR; He HT; Siahaan TJ
    Bioorg Chem; 2002 Aug; 30(4):285-301. PubMed ID: 12392707
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Enhancing Oral Bioavailability of Cyclic RGD Hexa-peptides by the Lipophilic Prodrug Charge Masking Approach: Redirection of Peptide Intestinal Permeability from a Paracellular to Transcellular Pathway.
    Schumacher-Klinger A; Fanous J; Merzbach S; Weinmüller M; Reichart F; Räder AFB; Gitlin-Domagalska A; Gilon C; Kessler H; Hoffman A
    Mol Pharm; 2018 Aug; 15(8):3468-3477. PubMed ID: 29976060
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Inhibition of intestinal metabolism of the antiviral ester prodrug bis(POC)-PMPA by nature-identical fruit extracts as a strategy to enhance its oral absorption: an in vitro study.
    Van Gelder J; Annaert P; Naesens L; De Clercq E; Van den Mooter G; Kinget R; Augustijns P
    Pharm Res; 1999 Jul; 16(7):1035-40. PubMed ID: 10450927
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Transport of levovirin prodrugs in the human intestinal Caco-2 cell line.
    Li F; Hong L; Mau CI; Chan R; Hendricks T; Dvorak C; Yee C; Harris J; Alfredson T
    J Pharm Sci; 2006 Jun; 95(6):1318-25. PubMed ID: 16634069
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Quantitative analysis of a model opioid peptide and its cyclic prodrugs in rat plasma using high-performance liquid chromatography with fluorescence and tandem mass spectrometric detection.
    Yang JZ; Bastian KC; Moore RD; Stobaugh JF; Borchardt RT
    J Chromatogr B Analyt Technol Biomed Life Sci; 2002 Nov; 780(2):269-81. PubMed ID: 12401352
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Transport, uptake, and metabolism of the bis(pivaloyloxymethyl)-ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine in an in vitro cell culture system of the intestinal mucosa (Caco-2).
    Annaert P; Kinget R; Naesens L; de Clercq E; Augustijns P
    Pharm Res; 1997 Apr; 14(4):492-6. PubMed ID: 9144737
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Bifunctional peptidomimetic prodrugs of didanosine for improved intestinal permeability and enhanced acidic stability: synthesis, transepithelial transport, chemical stability and pharmacokinetics.
    Yan Z; Sun J; Chang Y; Liu Y; Fu Q; Xu Y; Sun Y; Pu X; Zhang Y; Jing Y; Yin S; Zhu M; Wang Y; He Z
    Mol Pharm; 2011 Apr; 8(2):319-29. PubMed ID: 21280612
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Functional characterization of peptide transporters in MDCKII-MDR1 cell line as a model for oral absorption studies.
    Agarwal S; Jain R; Pal D; Mitra AK
    Int J Pharm; 2007 Mar; 332(1-2):147-52. PubMed ID: 17097248
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 12.