133 related articles for article (PubMed ID: 9973487)
1. Functional characterization of the somatic hypermutation process leading to antibody D1.3, a high affinity antibody directed against lysozyme.
England P; Nageotte R; Renard M; Page AL; Bedouelle H
J Immunol; 1999 Feb; 162(4):2129-36. PubMed ID: 9973487
[TBL] [Abstract][Full Text] [Related]
2. The contribution of contact and non-contact residues of antibody in the affinity of binding to antigen. The interaction of mutant D1.3 antibodies with lysozyme.
Hawkins RE; Russell SJ; Baier M; Winter G
J Mol Biol; 1993 Dec; 234(4):958-64. PubMed ID: 8263942
[TBL] [Abstract][Full Text] [Related]
3. A mutational analysis of binding interactions in an antigen-antibody protein-protein complex.
Dall'Acqua W; Goldman ER; Lin W; Teng C; Tsuchiya D; Li H; Ysern X; Braden BC; Li Y; Smith-Gill SJ; Mariuzza RA
Biochemistry; 1998 Jun; 37(22):7981-91. PubMed ID: 9609690
[TBL] [Abstract][Full Text] [Related]
4. X-ray snapshots of the maturation of an antibody response to a protein antigen.
Li Y; Li H; Yang F; Smith-Gill SJ; Mariuzza RA
Nat Struct Biol; 2003 Jun; 10(6):482-8. PubMed ID: 12740607
[TBL] [Abstract][Full Text] [Related]
5. Crystal structure of the complex of the variable domain of antibody D1.3 and turkey egg white lysozyme: a novel conformational change in antibody CDR-L3 selects for antigen.
Braden BC; Fields BA; Ysern X; Goldbaum FA; Dall'Acqua W; Schwarz FP; Poljak RJ; Mariuzza RA
J Mol Biol; 1996 Apr; 257(5):889-94. PubMed ID: 8632472
[TBL] [Abstract][Full Text] [Related]
6. Experimental analysis by site-directed mutagenesis of somatic mutation effects on affinity and fine specificity in antibodies specific for lysozyme.
Lavoie TB; Drohan WN; Smith-Gill SJ
J Immunol; 1992 Jan; 148(2):503-13. PubMed ID: 1729369
[TBL] [Abstract][Full Text] [Related]
7. A mutational analysis of the binding of two different proteins to the same antibody.
Dall'Acqua W; Goldman ER; Eisenstein E; Mariuzza RA
Biochemistry; 1996 Jul; 35(30):9667-76. PubMed ID: 8703938
[TBL] [Abstract][Full Text] [Related]
8. Thermodynamic characterization of affinity maturation: the D1.3 antibody and a higher-affinity mutant.
VanAntwerp JJ; Wittrup KD
J Mol Recognit; 1998; 11(1-6):10-3. PubMed ID: 10076798
[TBL] [Abstract][Full Text] [Related]
9. In vitro antibody maturation. Improvement of a high affinity, neutralizing antibody against IL-1 beta.
Jackson JR; Sathe G; Rosenberg M; Sweet R
J Immunol; 1995 Apr; 154(7):3310-9. PubMed ID: 7897213
[TBL] [Abstract][Full Text] [Related]
10. Contribution of heavy chain junctional amino acid diversity to antibody affinity among p-azophenylarsonate-specific antibodies.
Parhami-Seren B; Margolies MN
J Immunol; 1996 Sep; 157(5):2066-72. PubMed ID: 8757328
[TBL] [Abstract][Full Text] [Related]
11. Tolerance of single, but not multiple, amino acid replacements in antibody VH CDR 2: a means of minimizing B cell wastage from somatic hypermutation?
Brown M; Rittenburg MB; Chen C; Roberts VA
J Immunol; 1996 May; 156(9):3285-91. PubMed ID: 8617951
[TBL] [Abstract][Full Text] [Related]
12. Affinity maturation increases the stability and plasticity of the Fv domain of anti-protein antibodies.
Acierno JP; Braden BC; Klinke S; Goldbaum FA; Cauerhff A
J Mol Biol; 2007 Nov; 374(1):130-46. PubMed ID: 17916365
[TBL] [Abstract][Full Text] [Related]
13. Modulation of antibody affinity by an engineered amino acid substitution.
Wong YW; Kussie PH; Parhami-Seren B; Margolies MN
J Immunol; 1995 Apr; 154(7):3351-8. PubMed ID: 7897218
[TBL] [Abstract][Full Text] [Related]
14. Knowledge-based design of reagentless fluorescent biosensors from recombinant antibodies.
Renard M; Belkadi L; Hugo N; England P; Altschuh D; Bedouelle H
J Mol Biol; 2002 Apr; 318(2):429-42. PubMed ID: 12051849
[TBL] [Abstract][Full Text] [Related]
15. Somatic mutation in VH complementarity-determining region 2 and framework region 2: differential effects on antigen binding and Ig secretion.
Wiens GD; Heldwein KA; Stenzel-Poore MP; Rittenberg MB
J Immunol; 1997 Aug; 159(3):1293-302. PubMed ID: 9233625
[TBL] [Abstract][Full Text] [Related]
16. Dissection of the IgNAR V domain: molecular scanning and orthologue database mining define novel IgNAR hallmarks and affinity maturation mechanisms.
Fennell BJ; Darmanin-Sheehan A; Hufton SE; Calabro V; Wu L; Müller MR; Cao W; Gill D; Cunningham O; Finlay WJ
J Mol Biol; 2010 Jul; 400(2):155-70. PubMed ID: 20450918
[TBL] [Abstract][Full Text] [Related]
17. Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen.
Chen Y; Wiesmann C; Fuh G; Li B; Christinger HW; McKay P; de Vos AM; Lowman HB
J Mol Biol; 1999 Nov; 293(4):865-81. PubMed ID: 10543973
[TBL] [Abstract][Full Text] [Related]
18. Probing the interaction between a high-affinity single-chain Fv and a pyrimidine (6-4) pyrimidone photodimer by site-directed mutagenesis.
Kobayashi H; Morioka H; Tobisawa K; Torizawa T; Kato K; Shimada I; Nikaido O; Stewart JD; Ohtsuka E
Biochemistry; 1999 Jan; 38(2):532-9. PubMed ID: 9888792
[TBL] [Abstract][Full Text] [Related]
19. Improving the affinity and the fine specificity of an anti-cortisol antibody by parsimonious mutagenesis and phage display.
Chames P; Coulon S; Baty D
J Immunol; 1998 Nov; 161(10):5421-9. PubMed ID: 9820517
[TBL] [Abstract][Full Text] [Related]
20. Effects on interaction kinetics of mutations at the VH-VL interface of Fabs depend on the structural context.
Khalifa MB; Weidenhaupt M; Choulier L; Chatellier J; Rauffer-Bruyère N; Altschuh D; Vernet T
J Mol Recognit; 2000; 13(3):127-39. PubMed ID: 10867708
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]