BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

142 related articles for article (PubMed ID: 9988711)

  • 1. Inhibition of DNA synthesis by a farnesyltransferase inhibitor involves inhibition of the p70(s6k) pathway.
    Law BK; Nørgaard P; Gnudi L; Kahn BB; Poulson HS; Moses HL
    J Biol Chem; 1999 Feb; 274(8):4743-8. PubMed ID: 9988711
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Farnesyltransferase inhibitor induces rapid growth arrest and blocks p70s6k activation by multiple stimuli.
    Law BK; Norgaard P; Moses HL
    J Biol Chem; 2000 Apr; 275(15):10796-801. PubMed ID: 10753872
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Growth inhibition by the farnesyltransferase inhibitor FTI-277 involves Bcl-2 expression and defective association with Raf-1 in liver cancer cell lines.
    Mazzocca A; Giusti S; Hamilton AD; Sebti SM; Pantaleo P; Carloni V
    Mol Pharmacol; 2003 Jan; 63(1):159-66. PubMed ID: 12488548
    [TBL] [Abstract][Full Text] [Related]  

  • 4. p70 S6 kinase-mediated protein synthesis is a critical step for vascular endothelial cell proliferation.
    Viñals F; Chambard JC; Pouysségur J
    J Biol Chem; 1999 Sep; 274(38):26776-82. PubMed ID: 10480882
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Transformation-selective apoptotic program triggered by farnesyltransferase inhibitors requires Bin1.
    DuHadaway JB; Du W; Donover S; Baker J; Liu AX; Sharp DM; Muller AJ; Prendergast GC
    Oncogene; 2003 Jun; 22(23):3578-88. PubMed ID: 12789266
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Signal pathways involved in activation of p70S6K and phosphorylation of 4E-BP1 following exposure of multiple myeloma tumor cells to interleukin-6.
    Shi Y; Hsu JH; Hu L; Gera J; Lichtenstein A
    J Biol Chem; 2002 May; 277(18):15712-20. PubMed ID: 11872747
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Farnesyltransferase inhibitors reverse altered growth and distribution of actin filaments in Tsc-deficient cells via inhibition of both rapamycin-sensitive and -insensitive pathways.
    Gau CL; Kato-Stankiewicz J; Jiang C; Miyamoto S; Guo L; Tamanoi F
    Mol Cancer Ther; 2005 Jun; 4(6):918-26. PubMed ID: 15956249
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The role of c-Myc on granulocyte colony-stimulating factor-dependent neutrophilic proliferation and differentiation of HL-60 cells.
    Kanayasu-Toyoda T; Yamaguchi T; Oshizawa T; Uchida E; Hayakawa T
    Biochem Pharmacol; 2003 Jul; 66(1):133-40. PubMed ID: 12818373
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines.
    Lerner EC; Zhang TT; Knowles DB; Qian Y; Hamilton AD; Sebti SM
    Oncogene; 1997 Sep; 15(11):1283-8. PubMed ID: 9315095
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Osmotic stress inhibits p70/85 S6 kinase through activation of a protein phosphatase.
    Parrott LA; Templeton DJ
    J Biol Chem; 1999 Aug; 274(35):24731-6. PubMed ID: 10455142
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Regulation of protein synthesis by cholecystokinin in rat pancreatic acini involves PHAS-I and the p70 S6 kinase pathway.
    Bragado MJ; Groblewski GE; Williams JA
    Gastroenterology; 1998 Sep; 115(3):733-42. PubMed ID: 9721171
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Rapamycin dissociates p70(S6K) activation from DNA synthesis stimulated by bombesin and insulin in Swiss 3T3 cells.
    Withers DJ; Seufferlein T; Mann D; Garcia B; Jones N; Rozengurt E
    J Biol Chem; 1997 Jan; 272(4):2509-14. PubMed ID: 8999966
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts.
    Sun J; Qian Y; Hamilton AD; Sebti SM
    Oncogene; 1998 Mar; 16(11):1467-73. PubMed ID: 9525745
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Salicylate-induced growth arrest is associated with inhibition of p70s6k and down-regulation of c-myc, cyclin D1, cyclin A, and proliferating cell nuclear antigen.
    Law BK; Waltner-Law ME; Entingh AJ; Chytil A; Aakre ME; Nørgaard P; Moses HL
    J Biol Chem; 2000 Dec; 275(49):38261-7. PubMed ID: 10993886
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Farnesyltransferase inhibitor FTI-277 prevents autocrine growth stimulation of neuroblastoma by BDNF.
    Girgert R; Wittrock J; Pfister S; Schweizer P
    J Cancer Res Clin Oncol; 2003 Apr; 129(4):227-33. PubMed ID: 12700894
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) inhibitors restore anoikis sensitivity in human breast cancer cell lines with a constitutively activated extracellular-regulated kinase (ERK) pathway.
    Fukazawa H; Noguchi K; Murakami Y; Uehara Y
    Mol Cancer Ther; 2002 Mar; 1(5):303-9. PubMed ID: 12489846
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Activation of mRNA translation in rat cardiac myocytes by insulin involves multiple rapamycin-sensitive steps.
    Wang L; Wang X; Proud CG
    Am J Physiol Heart Circ Physiol; 2000 Apr; 278(4):H1056-68. PubMed ID: 10749698
    [TBL] [Abstract][Full Text] [Related]  

  • 18. HGF- and KGF-induced activation of PI-3K/p70 s6 kinase pathway in corneal epithelial cells: its relevance in wound healing.
    Chandrasekher G; Kakazu AH; Bazan HE
    Exp Eye Res; 2001 Aug; 73(2):191-202. PubMed ID: 11446769
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Mitogenic signalling by delta opioid receptors expressed in rat-1 fibroblasts involves activation of the p70s6k/p85s6k S6 kinase.
    Wilson MA; Burt AR; Milligan G; Anderson NG
    Biochem J; 1997 Jul; 325 ( Pt 1)(Pt 1):217-22. PubMed ID: 9224649
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons.
    Lekmine F; Uddin S; Sassano A; Parmar S; Brachmann SM; Majchrzak B; Sonenberg N; Hay N; Fish EN; Platanias LC
    J Biol Chem; 2003 Jul; 278(30):27772-80. PubMed ID: 12759354
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.