Terms: = Brain cancer AND CRTC1, Q6UUV9, 23373, ENSG00000105662, KIAA0616, TORC1, MECT1, WAMTP1, FLJ14027
21 results:
1. Chronic but not acute nicotine treatment ameliorates acute inflammation-induced working memory impairment by increasing crtc1 and HCN2 in adult male mice.
Wang X; Wang Q; Song M; Wang Y; Shen X; Sun Y; Guo C; Geng P; Ma C; Jin X
CNS Neurosci Ther; 2024 Feb; 30(2):e14627. PubMed ID: 38353058
[TBL] [Abstract] [Full Text] [Related]
2. crtc1 is a potential target to delay aging-induced cognitive deficit by protecting the integrity of the blood-brain barrier via inhibiting inflammation.
Wang Y; Du W; Sun Y; Zhang J; Ma C; Jin X
J Cereb Blood Flow Metab; 2023 Jul; 43(7):1042-1059. PubMed ID: 37086081
[TBL] [Abstract] [Full Text] [Related]
3. Investigation of morpholine isosters for the development of a potent, selective and metabolically stable mTOR kinase inhibitor.
De Pascale M; Bissegger L; Tarantelli C; Beaufils F; Prescimone A; Mohamed Seid Hedad H; Kayali O; Orbegozo C; Raguž L; Schaefer T; Hebeisen P; Bertoni F; Wymann MP; Borsari C
Eur J Med Chem; 2023 Feb; 248():115038. PubMed ID: 36634458
[TBL] [Abstract] [Full Text] [Related]
4. Regulation of torc1 by MAPK Signaling Determines Sensitivity and Acquired Resistance to Trametinib in Pediatric BRAFV600E brain Tumor Models.
Li F; Bondra KM; Ghilu S; Studebaker A; Liu Q; Michalek JE; Kogiso M; Li XN; Kalapurakal JA; James CD; Burma S; Kurmasheva RT; Houghton PJ
Clin Cancer Res; 2022 Sep; 28(17):3836-3849. PubMed ID: 35797217
[TBL] [Abstract] [Full Text] [Related]
5. Chemical and Structural Strategies to Selectively Target mTOR Kinase.
Borsari C; De Pascale M; Wymann MP
ChemMedChem; 2021 Sep; 16(18):2744-2759. PubMed ID: 34114360
[TBL] [Abstract] [Full Text] [Related]
6. torc1/2 kinase inhibition depletes glutathione and synergizes with carboplatin to suppress the growth of MYC-driven medulloblastoma.
Maynard RE; Poore B; Hanaford AR; Pham K; James M; Alt J; Park Y; Slusher BS; Tamayo P; Mesirov J; Archer TC; Pomeroy SL; Eberhart CG; Raabe EH
Cancer Lett; 2021 Apr; 504():137-145. PubMed ID: 33571541
[TBL] [Abstract] [Full Text] [Related]
7. Synergistic activity of mtorc1/2 kinase and MEK inhibitors suppresses pediatric low-grade glioma tumorigenicity and vascularity.
Arnold A; Yuan M; Price A; Harris L; Eberhart CG; Raabe EH
Neuro Oncol; 2020 Apr; 22(4):563-574. PubMed ID: 31841591
[TBL] [Abstract] [Full Text] [Related]
8. brain-penetrant PQR620 mTOR and PQR530 PI3K/mTOR inhibitor reduce huntingtin levels in cell models of HD.
Singer E; Walter C; Fabbro D; Rageot D; Beaufils F; Wymann MP; Rischert N; Riess O; Hillmann P; Nguyen HP
Neuropharmacology; 2020 Jan; 162():107812. PubMed ID: 31622602
[TBL] [Abstract] [Full Text] [Related]
9. Copy number alterations determined by single nucleotide polymorphism array testing in the clinical laboratory are indicative of gene fusions in pediatric cancer patients.
Busse TM; Roth JJ; Wilmoth D; Wainwright L; Tooke L; Biegel JA
Genes Chromosomes Cancer; 2017 Oct; 56(10):730-749. PubMed ID: 28597942
[TBL] [Abstract] [Full Text] [Related]
10. The torc1/2 inhibitor TAK228 sensitizes atypical teratoid rhabdoid tumors to cisplatin-induced cytotoxicity.
Rubens JA; Wang SZ; Price A; Weingart MF; Allen SJ; Orr BA; Eberhart CG; Raabe EH
Neuro Oncol; 2017 Oct; 19(10):1361-1371. PubMed ID: 28582547
[TBL] [Abstract] [Full Text] [Related]
11. Case of parotid mucoepidermoid carcinoma: Expanding the spectrum of von Hippel-Lindau-related neoplasms.
Berger MH; Kerr DA; Rangel Filho AE; Sargi ZB
Head Neck; 2017 Mar; 39(3):E51-E54. PubMed ID: 28006088
[TBL] [Abstract] [Full Text] [Related]
12. CREB-regulated transcription coactivator 1 enhances CREB-dependent gene expression in spinal cord to maintain the bone cancer pain in mice.
Liang Y; Liu Y; Hou B; Zhang W; Liu M; Sun YE; Ma Z; Gu X
Mol Pain; 2016; 12():. PubMed ID: 27060162
[TBL] [Abstract] [Full Text] [Related]
13. New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.
Lu Y; Day FR; Gustafsson S; Buchkovich ML; Na J; Bataille V; Cousminer DL; Dastani Z; Drong AW; Esko T; Evans DM; Falchi M; Feitosa MF; Ferreira T; Hedman ÅK; Haring R; Hysi PG; Iles MM; Justice AE; Kanoni S; Lagou V; Li R; Li X; Locke A; Lu C; Mägi R; Perry JR; Pers TH; Qi Q; Sanna M; Schmidt EM; Scott WR; Shungin D; Teumer A; Vinkhuyzen AA; Walker RW; Westra HJ; Zhang M; Zhang W; Zhao JH; Zhu Z; Afzal U; Ahluwalia TS; Bakker SJ; Bellis C; Bonnefond A; Borodulin K; Buchman AS; Cederholm T; Choh AC; Choi HJ; Curran JE; de Groot LC; De Jager PL; Dhonukshe-Rutten RA; Enneman AW; Eury E; Evans DS; Forsen T; Friedrich N; Fumeron F; Garcia ME; Gärtner S; Han BG; Havulinna AS; Hayward C; Hernandez D; Hillege H; Ittermann T; Kent JW; Kolcic I; Laatikainen T; Lahti J; Mateo Leach I; Lee CG; Lee JY; Liu T; Liu Y; Lobbens S; Loh M; Lyytikäinen LP; Medina-Gomez C; Michaëlsson K; Nalls MA; Nielson CM; Oozageer L; Pascoe L; Paternoster L; Polašek O; Ripatti S; Sarzynski MA; Shin CS; Narančić NS; Spira D; Srikanth P; Steinhagen-Thiessen E; Sung YJ; Swart KM; Taittonen L; Tanaka T; Tikkanen E; van der Velde N; van Schoor NM; Verweij N; Wright AF; Yu L; Zmuda JM; Eklund N; Forrester T; Grarup N; Jackson AU; Kristiansson K; Kuulasmaa T; Kuusisto J; Lichtner P; Luan J; Mahajan A; Männistö S; Palmer CD; Ried JS; Scott RA; Stancáková A; Wagner PJ; Demirkan A; Döring A; Gudnason V; Kiel DP; Kühnel B; Mangino M; Mcknight B; Menni C; O'Connell JR; Oostra BA; Shuldiner AR; Song K; Vandenput L; van Duijn CM; Vollenweider P; White CC; Boehnke M; Boettcher Y; Cooper RS; Forouhi NG; Gieger C; Grallert H; Hingorani A; Jørgensen T; Jousilahti P; Kivimaki M; Kumari M; Laakso M; Langenberg C; Linneberg A; Luke A; Mckenzie CA; Palotie A; Pedersen O; Peters A; Strauch K; Tayo BO; Wareham NJ; Bennett DA; Bertram L; Blangero J; Blüher M; Bouchard C; Campbell H; Cho NH; Cummings SR; Czerwinski SA; Demuth I; Eckardt R; Eriksson JG; Ferrucci L; Franco OH; Froguel P; Gansevoort RT; Hansen T; Harris TB; Hastie N; Heliövaara M; Hofman A; Jordan JM; Jula A; Kähönen M; Kajantie E; Knekt PB; Koskinen S; Kovacs P; Lehtimäki T; Lind L; Liu Y; Orwoll ES; Osmond C; Perola M; Pérusse L; Raitakari OT; Rankinen T; Rao DC; Rice TK; Rivadeneira F; Rudan I; Salomaa V; Sørensen TI; Stumvoll M; Tönjes A; Towne B; Tranah GJ; Tremblay A; Uitterlinden AG; van der Harst P; Vartiainen E; Viikari JS; Vitart V; Vohl MC; Völzke H; Walker M; Wallaschofski H; Wild S; Wilson JF; Yengo L; Bishop DT; Borecki IB; Chambers JC; Cupples LA; Dehghan A; Deloukas P; Fatemifar G; Fox C; Furey TS; Franke L; Han J; Hunter DJ; Karjalainen J; Karpe F; Kaplan RC; Kooner JS; McCarthy MI; Murabito JM; Morris AP; Bishop JA; North KE; Ohlsson C; Ong KK; Prokopenko I; Richards JB; Schadt EE; Spector TD; Widén E; Willer CJ; Yang J; Ingelsson E; Mohlke KL; Hirschhorn JN; Pospisilik JA; Zillikens MC; Lindgren C; Kilpeläinen TO; Loos RJ
Nat Commun; 2016 Feb; 7():10495. PubMed ID: 26833246
[TBL] [Abstract] [Full Text] [Related]
14. Supportive evidence for FOXP1, BARX1, and FOXF1 as genetic risk loci for the development of esophageal adenocarcinoma.
Becker J; May A; Gerges C; Anders M; Veits L; Weise K; Czamara D; Lyros O; Manner H; Terheggen G; Venerito M; Noder T; Mayershofer R; Hofer JH; Karch HW; Ahlbrand CJ; Arras M; Hofer S; Mangold E; Heilmann-Heimbach S; Heinrichs SK; Hess T; Kiesslich R; Izbicki JR; Hölscher AH; Bollschweiler E; Malfertheiner P; Lang H; Moehler M; Lorenz D; Müller-Myhsok B; Ott K; Schmidt T; Whiteman DC; Vaughan TL; Nöthen MM; Hackelsberger A; Schumacher B; Pech O; Vashist Y; Vieth M; Weismüller J; Neuhaus H; Rösch T; Ell C; Gockel I; Schumacher J
Cancer Med; 2015 Nov; 4(11):1700-4. PubMed ID: 26383589
[TBL] [Abstract] [Full Text] [Related]
15. Dysregulated crtc1 activity is a novel component of PGE2 signaling that contributes to colon cancer growth.
Schumacher Y; Aparicio T; Ourabah S; Baraille F; Martin A; Wind P; Dentin R; Postic C; Guilmeau S
Oncogene; 2016 May; 35(20):2602-14. PubMed ID: 26300003
[TBL] [Abstract] [Full Text] [Related]
16. Regulation of torc1 in response to amino acid starvation via lysosomal recruitment of TSC2.
Demetriades C; Doumpas N; Teleman AA
Cell; 2014 Feb; 156(4):786-99. PubMed ID: 24529380
[TBL] [Abstract] [Full Text] [Related]
17. STRIPAK complexes: structure, biological function, and involvement in human diseases.
Hwang J; Pallas DC
Int J Biochem Cell Biol; 2014 Feb; 47():118-48. PubMed ID: 24333164
[TBL] [Abstract] [Full Text] [Related]
18. Mucoepidermoid carcinoma: A yet unreported cancer associated with familial adenomatous polyposis.
Cazorla A; Viennet G; Uro-Coste E; Valmary-Degano S
J Craniomaxillofac Surg; 2014 Apr; 42(3):262-4. PubMed ID: 23830771
[TBL] [Abstract] [Full Text] [Related]
19. Proton-assisted amino acid transporter PAT1 complexes with Rag GTPases and activates torc1 on late endosomal and lysosomal membranes.
Ögmundsdóttir MH; Heublein S; Kazi S; Reynolds B; Visvalingam SM; Shaw MK; Goberdhan DC
PLoS One; 2012; 7(5):e36616. PubMed ID: 22574197
[TBL] [Abstract] [Full Text] [Related]
20. Enhanced activity of the CREB co-activator crtc1 in LKB1 null lung cancer.
Komiya T; Coxon A; Park Y; Chen WD; Zajac-Kaye M; Meltzer P; Karpova T; Kaye FJ
Oncogene; 2010 Mar; 29(11):1672-80. PubMed ID: 20010869
[TBL] [Abstract] [Full Text] [Related]
[Next]
