Terms: = Brain cancer AND CRTC1, Q6UUV9, 23373, ENSG00000105662, KIAA0616, TORC1, MECT1, WAMTP1, FLJ14027 AND Treatment
9 results:
1. Chronic but not acute nicotine treatment ameliorates acute inflammation-induced working memory impairment by increasing crtc1 and HCN2 in adult male mice.
Wang X; Wang Q; Song M; Wang Y; Shen X; Sun Y; Guo C; Geng P; Ma C; Jin X
CNS Neurosci Ther; 2024 Feb; 30(2):e14627. PubMed ID: 38353058
[TBL] [Abstract] [Full Text] [Related]
2. Investigation of morpholine isosters for the development of a potent, selective and metabolically stable mTOR kinase inhibitor.
De Pascale M; Bissegger L; Tarantelli C; Beaufils F; Prescimone A; Mohamed Seid Hedad H; Kayali O; Orbegozo C; Raguž L; Schaefer T; Hebeisen P; Bertoni F; Wymann MP; Borsari C
Eur J Med Chem; 2023 Feb; 248():115038. PubMed ID: 36634458
[TBL] [Abstract] [Full Text] [Related]
3. Regulation of torc1 by MAPK Signaling Determines Sensitivity and Acquired Resistance to Trametinib in Pediatric BRAFV600E brain Tumor Models.
Li F; Bondra KM; Ghilu S; Studebaker A; Liu Q; Michalek JE; Kogiso M; Li XN; Kalapurakal JA; James CD; Burma S; Kurmasheva RT; Houghton PJ
Clin Cancer Res; 2022 Sep; 28(17):3836-3849. PubMed ID: 35797217
[TBL] [Abstract] [Full Text] [Related]
4. Chemical and Structural Strategies to Selectively Target mTOR Kinase.
Borsari C; De Pascale M; Wymann MP
ChemMedChem; 2021 Sep; 16(18):2744-2759. PubMed ID: 34114360
[TBL] [Abstract] [Full Text] [Related]
5. Synergistic activity of mtorc1/2 kinase and MEK inhibitors suppresses pediatric low-grade glioma tumorigenicity and vascularity.
Arnold A; Yuan M; Price A; Harris L; Eberhart CG; Raabe EH
Neuro Oncol; 2020 Apr; 22(4):563-574. PubMed ID: 31841591
[TBL] [Abstract] [Full Text] [Related]
6. brain-penetrant PQR620 mTOR and PQR530 PI3K/mTOR inhibitor reduce huntingtin levels in cell models of HD.
Singer E; Walter C; Fabbro D; Rageot D; Beaufils F; Wymann MP; Rischert N; Riess O; Hillmann P; Nguyen HP
Neuropharmacology; 2020 Jan; 162():107812. PubMed ID: 31622602
[TBL] [Abstract] [Full Text] [Related]
7. The torc1/2 inhibitor TAK228 sensitizes atypical teratoid rhabdoid tumors to cisplatin-induced cytotoxicity.
Rubens JA; Wang SZ; Price A; Weingart MF; Allen SJ; Orr BA; Eberhart CG; Raabe EH
Neuro Oncol; 2017 Oct; 19(10):1361-1371. PubMed ID: 28582547
[TBL] [Abstract] [Full Text] [Related]
8. CREB-regulated transcription coactivator 1 enhances CREB-dependent gene expression in spinal cord to maintain the bone cancer pain in mice.
Liang Y; Liu Y; Hou B; Zhang W; Liu M; Sun YE; Ma Z; Gu X
Mol Pain; 2016; 12():. PubMed ID: 27060162
[TBL] [Abstract] [Full Text] [Related]
9. Dysregulated crtc1 activity is a novel component of PGE2 signaling that contributes to colon cancer growth.
Schumacher Y; Aparicio T; Ourabah S; Baraille F; Martin A; Wind P; Dentin R; Postic C; Guilmeau S
Oncogene; 2016 May; 35(20):2602-14. PubMed ID: 26300003
[TBL] [Abstract] [Full Text] [Related]
