Terms: = Brain cancer AND PTCH1, RP11-435O5_3, Q13635, PTCH, 5727, HPE7, FLJ26746, NBCCS, BCNS, PTC1, ENSG00000185920, FLJ42602 AND Treatment
58 results:
1. Plasma ctDNA Monitoring of a ptch1-Mutant Metastatic Adult Medulloblastoma Showing a Durable Benefit With Vismodegib.
Cabezas-Camarero S; García-Barberán V; Pérez-Alfayate R; Gómez Del Pulgar ME; Cabrera-Martin MN; Casado-Fariñas I; Pérez-Segura P
Oncologist; 2024 May; 29(5):377-383. PubMed ID: 38438322
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2. Prevalence of pathogenic variants in cancer-predisposing genes in second cancer after childhood solid cancers.
Yoshida M; Nakabayashi K; Yang W; Sato-Otsubo A; Tsujimoto SI; Ogata-Kawata H; Kawai T; Ishiwata K; Sakamoto M; Okamura K; Yoshida K; Shirai R; Osumi T; Kiyotani C; Shioda Y; Terashima K; Ishimaru S; Yuza Y; Takagi M; Arakawa Y; Imamura T; Hasegawa D; Inoue A; Yoshioka T; Ito S; Tomizawa D; Koh K; Matsumoto K; Kiyokawa N; Ogawa S; Manabe A; Niwa A; Hata K; Yang JJ; Kato M
Cancer Med; 2023 May; 12(10):11264-11273. PubMed ID: 37021926
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3. METTL3 regulates m
Zhang ZW; Teng X; Zhao F; Ma C; Zhang J; Xiao LF; Wang Y; Chang M; Tian Y; Li C; Zhang Z; Song S; Tong WM; Liu P; Niu Y
Cell Rep; 2022 Oct; 41(4):111530. PubMed ID: 36288719
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4. Gene Expression Profiling Identifies Two Chordoma Subtypes Associated with Distinct Molecular Mechanisms and Clinical Outcomes.
Bai J; Shi J; Zhang Y; Li C; Xiong Y; Koka H; Wang D; Zhang T; Song L; Luo W; Zhu B; Hicks B; Hutchinson A; Kirk E; Troester MA; Li M; Shen Y; Ma T; Wang J; Liu X; Wang S; Gui S; McMaster ML; Chanock SJ; Parry DM; Goldstein AM; Yang XR
Clin Cancer Res; 2023 Jan; 29(1):261-270. PubMed ID: 36260525
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5. Reduced ptch2 expression is associated with glioma development through its regulation of the PTEN/AKT signaling pathway.
Han J; Deng H; Xiong Y; Xia X; Bao C; Chen L; Zhao Q; Zhong S; Peng L; Zhong C
Biochem Biophys Res Commun; 2022 Oct; 627():76-83. PubMed ID: 36027694
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6. Curcumin analogue BDDD-721 exhibits more potent anticancer effects than curcumin on medulloblastoma by targeting Shh/Gli1 signaling pathway.
Gong W; Zhao W; Liu G; Shi L; Zhao X
Aging (Albany NY); 2022 Jul; 14(13):5464-5477. PubMed ID: 35802536
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7. Complement C3a activates astrocytes to promote medulloblastoma progression through TNF-α.
Gong B; Guo D; Zheng C; Ma Z; Zhang J; Qu Y; Li X; Li G; Zhang L; Wang Y
J Neuroinflammation; 2022 Jun; 19(1):159. PubMed ID: 35725556
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8. Molecular Stratification of Medulloblastoma: Clinical Outcomes and Therapeutic Interventions.
Sursal T; Ronecker JS; Dicpinigaitis AJ; Mohan AL; Tobias ME; Gandhi CD; Jhanwar-Uniyal M
Anticancer Res; 2022 May; 42(5):2225-2239. PubMed ID: 35489737
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9. mTORC1 promotes malignant large cell/anaplastic histology and is a targetable vulnerability in SHH-TP53 mutant medulloblastoma.
Conti V; Cominelli M; Pieri V; Gallotti AL; Pagano I; Zanella M; Mazzoleni S; Pivetta F; Patanè M; Scotti GM; Piras IS; Pollo B; Falini A; Zippo A; Castellano A; Maestro R; Poliani PL; Galli R
JCI Insight; 2021 Dec; 6(23):. PubMed ID: 34673573
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10. SOX9 Defines Distinct Populations of Cells in SHH Medulloblastoma but Is Not Required for Math1-Driven Tumor Formation.
Adolphe C; Millar A; Kojic M; Barkauskas DS; Sundström A; Swartling FJ; Hediyeh-Zadeh S; Tan CW; Davis MJ; Genovesi LA; Wainwright BJ
Mol Cancer Res; 2021 Nov; 19(11):1831-1839. PubMed ID: 34330843
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11. Identification of pseudolaric acid B as a novel Hedgehog pathway inhibitor in medulloblastoma.
Wei SF; He DH; Zhang SB; Lu Y; Ye X; Fan XZ; Wang H; Wang Q; Liu YQ
Biochem Pharmacol; 2021 Aug; 190():114593. PubMed ID: 33964282
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12. Medulloblastoma recurrence and metastatic spread are independent of colony-stimulating factor 1 receptor signaling and macrophage survival.
Crotty EE; Smith SMC; Brasel K; Pakiam F; Girard EJ; Connor YD; Zindy F; Mhyre AJ; Roussel MF; Olson JM
J Neurooncol; 2021 Jun; 153(2):225-237. PubMed ID: 33963961
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13. Differences in RNA and microRNA Expression Between ptch1- and SUFU-mutated Medulloblastoma.
Gershanov S; Toledano H; Pernicone N; Fichman S; Michowiz S; Pinhasov A; Goldenberg-Cohen N; Listovsky T; Salmon-Divon M
Cancer Genomics Proteomics; 2021; 18(3):335-347. PubMed ID: 33893086
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14. GPR126 regulates colorectal cancer cell proliferation by mediating HDAC2 and GLI2 expression.
Cui H; Yu W; Yu M; Luo Y; Yang M; Cong R; Chu X; Gao G; Zhong M
Cancer Sci; 2021 May; 112(5):1798-1810. PubMed ID: 33629464
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15. Integrated molecular analysis of adult sonic hedgehog (SHH)-activated medulloblastomas reveals two clinically relevant tumor subsets with VEGFA as potent prognostic indicator.
Korshunov A; Okonechnikov K; Stichel D; Ryzhova M; Schrimpf D; Sahm F; Sievers P; Absalyamova O; Zheludkova O; Golanov A; Jones DTW; Pfister SM; von Deimling A; Kool M
Neuro Oncol; 2021 Sep; 23(9):1576-1585. PubMed ID: 33589929
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16. Outcomes by Clinical and Molecular Features in Children With Medulloblastoma Treated With Risk-Adapted Therapy: Results of an International Phase III Trial (SJMB03).
Gajjar A; Robinson GW; Smith KS; Lin T; Merchant TE; Chintagumpala M; Mahajan A; Su J; Bouffet E; Bartels U; Schechter T; Hassall T; Robertson T; Nicholls W; Gururangan S; Schroeder K; Sullivan M; Wheeler G; Hansford JR; Kellie SJ; McCowage G; Cohn R; Fisher MJ; Krasin MJ; Stewart CF; Broniscer A; Buchhalter I; Tatevossian RG; Orr BA; Neale G; Klimo P; Boop F; Srinivasan A; Pfister SM; Gilbertson RJ; Onar-Thomas A; Ellison DW; Northcott PA
J Clin Oncol; 2021 Mar; 39(7):822-835. PubMed ID: 33405951
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17. Clinical and mutational profiles of adult medulloblastoma groups.
Wong GC; Li KK; Wang WW; Liu AP; Huang QJ; Chan AK; Poon MF; Chung NY; Wong QH; Chen H; Chan DTM; Liu XZ; Mao Y; Zhang ZY; Shi ZF; Ng HK
Acta Neuropathol Commun; 2020 Nov; 8(1):191. PubMed ID: 33172502
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18. Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology.
Golebiewska A; Hau AC; Oudin A; Stieber D; Yabo YA; Baus V; Barthelemy V; Klein E; Bougnaud S; Keunen O; Wantz M; Michelucci A; Neirinckx V; Muller A; Kaoma T; Nazarov PV; Azuaje F; De Falco A; Flies B; Richart L; Poovathingal S; Arns T; Grzyb K; Mock A; Herold-Mende C; Steino A; Brown D; May P; Miletic H; Malta TM; Noushmehr H; Kwon YJ; Jahn W; Klink B; Tanner G; Stead LF; Mittelbronn M; Skupin A; Hertel F; Bjerkvig R; Niclou SP
Acta Neuropathol; 2020 Dec; 140(6):919-949. PubMed ID: 33009951
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19. Transcriptional profiling of medulloblastoma with extensive nodularity (MBEN) reveals two clinically relevant tumor subsets with VSNL1 as potent prognostic marker.
Korshunov A; Okonechnikov K; Sahm F; Ryzhova M; Stichel D; Schrimpf D; Ghasemi DR; Pajtler KW; Antonelli M; Donofrio V; Mastronuzzi A; Rossi S; Camassei FD; Buccoliero AM; Haberler C; Slavc I; Dahiya S; Casalini B; Sievers P; Meyer J; Kumirova E; Zheludkova O; Golanov A; Jones DTW; Pfister SM; Kool M; von Deimling A
Acta Neuropathol; 2020 Mar; 139(3):583-596. PubMed ID: 31781912
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20. Targeting cyclin-dependent kinase 9 sensitizes medulloblastoma cells to chemotherapy.
Song H; Bhakat R; Kling MJ; Coulter DW; Chaturvedi NK; Ray S; Joshi SS
Biochem Biophys Res Commun; 2019 Dec; 520(2):250-256. PubMed ID: 31594641
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