Terms: = Breast cancer AND WHSC1L1, ENSG00000147548, 54904
13 results:
1. Identification of novel class inhibitors of NSD3 methyltransferase showing a unique, bivalent binding mode in the SET domain.
Kim S; Hwang I; Kim SH; Chung HW; Ji MJ; Moon S; Park HM; Kong G; Hur W
Chem Biol Drug Des; 2023 Sep; 102(3):500-513. PubMed ID: 37072259
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2. Genetic characterisation of adult primary pleomorphic uterine rhabdomyosarcoma and comparison with uterine carcinosarcoma.
Ashley CW; Da Cruz Paula A; Ferrando L; Gularte-Mérida R; Sebastiao APM; Brown DN; Gazzo AM; Pareja F; Stylianou A; Abu-Rustum NR; Reis-Filho JS; Buehler D; Weisman P; Chiang S; Weigelt B
Histopathology; 2021 Aug; 79(2):176-186. PubMed ID: 33527450
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3. Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3.
Böttcher J; Dilworth D; Reiser U; Neumüller RA; Schleicher M; Petronczki M; Zeeb M; Mischerikow N; Allali-Hassani A; Szewczyk MM; Li F; Kennedy S; Vedadi M; Barsyte-Lovejoy D; Brown PJ; Huber KVM; Rogers CM; Wells CI; Fedorov O; Rumpel K; Zoephel A; Mayer M; Wunberg T; Böse D; Zahn S; Arnhof H; Berger H; Reiser C; Hörmann A; Krammer T; Corcokovic M; Sharps B; Winkler S; Häring D; Cockcroft XL; Fuchs JE; Müllauer B; Weiss-Puxbaum A; Gerstberger T; Boehmelt G; Vakoc CR; Arrowsmith CH; Pearson M; McConnell DB
Nat Chem Biol; 2019 Aug; 15(8):822-829. PubMed ID: 31285596
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4. Development of mammary hyperplasia, dysplasia, and invasive ductal carcinoma in transgenic mice expressing the 8p11 amplicon oncogene NSD3.
Turner-Ivey B; Smith EL; Rutkovsky AC; Spruill LS; Mills JN; Ethier SP
Breast Cancer Res Treat; 2017 Jul; 164(2):349-358. PubMed ID: 28484924
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5. An mRNA Gene Expression-Based Signature to Identify FGFR1-Amplified Estrogen Receptor-Positive breast Tumors.
Luo J; Liu S; Leung S; Gru AA; Tao Y; Hoog J; Ho J; Davies SR; Allred DC; Salavaggione AL; Snider J; Mardis ER; Nielsen TO; Ellis MJ
J Mol Diagn; 2017 Jan; 19(1):147-161. PubMed ID: 27993329
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6. Amplification of whsc1l1 regulates expression and estrogen-independent activation of ERα in SUM-44 breast cancer cells and is associated with ERα over-expression in breast cancer.
Irish JC; Mills JN; Turner-Ivey B; Wilson RC; Guest ST; Rutkovsky A; Dombkowski A; Kappler CS; Hardiman G; Ethier SP
Mol Oncol; 2016 Jun; 10(6):850-65. PubMed ID: 27005559
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7. Mutation spectra of histone methyltransferases with canonical SET domains and EZH2-targeted therapy.
Katoh M
Epigenomics; 2016 Feb; 8(2):285-305. PubMed ID: 26411517
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8. Genetic alterations of histone lysine methyltransferases and their significance in breast cancer.
Liu L; Kimball S; Liu H; Holowatyj A; Yang ZQ
Oncotarget; 2015 Feb; 6(4):2466-82. PubMed ID: 25537518
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9. PPAPDC1B and whsc1l1 are common drivers of the 8p11-12 amplicon, not only in breast tumors but also in pancreatic adenocarcinomas and lung tumors.
Mahmood SF; Gruel N; Nicolle R; Chapeaublanc E; Delattre O; Radvanyi F; Bernard-Pierrot I
Am J Pathol; 2013 Nov; 183(5):1634-1644. PubMed ID: 24051013
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10. Transforming properties of 8p11-12 amplified genes in human breast cancer.
Yang ZQ; Liu G; Bollig-Fischer A; Giroux CN; Ethier SP
Cancer Res; 2010 Nov; 70(21):8487-97. PubMed ID: 20940404
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11. The NSD3L histone methyltransferase regulates cell cycle and cell invasion in breast cancer cells.
Zhou Z; Thomsen R; Kahns S; Nielsen AL
Biochem Biophys Res Commun; 2010 Jul; 398(3):565-70. PubMed ID: 20599755
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12. Characterization of the recurrent 8p11-12 amplicon identifies PPAPDC1B, a phosphatase protein, as a new therapeutic target in breast cancer.
Bernard-Pierrot I; Gruel N; Stransky N; Vincent-Salomon A; Reyal F; Raynal V; Vallot C; Pierron G; Radvanyi F; Delattre O
Cancer Res; 2008 Sep; 68(17):7165-75. PubMed ID: 18757432
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13. whsc1l1, on human chromosome 8p11.2, closely resembles WHSC1 and maps to a duplicated region shared with 4p16.3.
Stec I; van Ommen GJ; den Dunnen JT
Genomics; 2001 Aug; 76(1-3):5-8. PubMed ID: 11549311
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