Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

Terms: = Colorectal cancer AND AKT1, P31749, RAC-ALPHA, RAC, PRKBA, PKB-ALPHA, PKB, MGC99656, AKT, ENSG00000142208, 207 AND Treatment
1566 results:

  • 1. Discovery of a novel small-molecule activator of SIRT3 that inhibits cell proliferation and migration by apoptosis and autophagy-dependent cell death pathways in colorectal cancer.
    Mou Y; Chen Y; Fan Z; Ye L; Hu B; Han B; Wang G
    Bioorg Chem; 2024 May; 146():107327. PubMed ID: 38579616
    [TBL] [Abstract] [Full Text] [Related]  

  • 2. PI3K/akt/mTOR Signaling Pathway as a Target for colorectal cancer treatment.
    Leiphrakpam PD; Are C
    Int J Mol Sci; 2024 Mar; 25(6):. PubMed ID: 38542151
    [TBL] [Abstract] [Full Text] [Related]  

  • 3. Timing of Surgery and Social Determinants of Health Related to Pathologic Complete Response after Total Neoadjuvant Therapy for Rectal Adenocarcinoma: Retrospective Study of National cancer Database.
    Mai M; Goldman J; Appiah D; Abdulrahman R; Kidwell J; Shi Z
    Curr Oncol; 2024 Feb; 31(3):1291-1301. PubMed ID: 38534930
    [TBL] [Abstract] [Full Text] [Related]  

  • 4. Reduced chemokine C-C motif ligand 1 expression may negatively regulate colorectal cancer progression at liver metastatic sites.
    Iwata M; Haraguchi R; Kitazawa R; Ito C; Ogawa K; Takada Y; Kitazawa S
    J Cell Mol Med; 2024 Apr; 28(7):e18193. PubMed ID: 38506205
    [TBL] [Abstract] [Full Text] [Related]  

  • 5. Inhibition of PI3K/akt signaling using BKM120 reduced the proliferation and migration potentials of colorectal cancer cells and enhanced cisplatin-induced cytotoxicity.
    Khameneh SC; Sari S; Razi S; Yousefi AM; Bashash D
    Mol Biol Rep; 2024 Mar; 51(1):420. PubMed ID: 38483663
    [TBL] [Abstract] [Full Text] [Related]  

  • 6. Inhibition of Multifunctional Protein p32/C1QBP Promotes Cytostatic Effects in Colon cancer Cells by Altering Mitogenic Signaling Pathways and Promoting Mitochondrial Damage.
    Egusquiza-Alvarez CA; Moreno-Londoño AP; Alvarado-Ortiz E; Ramos-Godínez MDP; Sarabia-Sánchez MA; Castañeda-Patlán MC; Robles-Flores M
    Int J Mol Sci; 2024 Feb; 25(5):. PubMed ID: 38473963
    [TBL] [Abstract] [Full Text] [Related]  

  • 7. Role of deubiquitinase JOSD2 in the pathogenesis of esophageal squamous cell carcinoma.
    Wang WP; Shi D; Yun D; Hu J; Wang JF; Liu J; Yang YP; Li MR; Wang JF; Kong DL
    World J Gastroenterol; 2024 Feb; 30(6):565-578. PubMed ID: 38463028
    [TBL] [Abstract] [Full Text] [Related]  

  • 8. Regulation of metastatic potential by drug repurposing and mitochondrial targeting in colorectal cancer cells.
    Mathur S; Srivastava P; Srivastava A; Rai NK; Abbas S; Kumar A; Tiwari M; Sharma LK
    BMC Cancer; 2024 Mar; 24(1):323. PubMed ID: 38459456
    [TBL] [Abstract] [Full Text] [Related]  

  • 9. Understanding the molecular mechanism responsible for developing therapeutic radiation-induced radioresistance of rectal cancer and improving the clinical outcomes of radiotherapy - A review.
    Jain SM; Nagainallur Ravichandran S; Murali Kumar M; Banerjee A; Sun-Zhang A; Zhang H; Pathak R; Sun XF; Pathak S
    Cancer Biol Ther; 2024 Dec; 25(1):2317999. PubMed ID: 38445632
    [TBL] [Abstract] [Full Text] [Related]  

  • 10. Synergistic antitumor activity between HER2 antibody-drug conjugate and chemotherapy for treating advanced colorectal cancer.
    Liu H; Zhou D; Liu D; Xu X; Zhang K; Hu R; Xiong P; Wang C; Zeng X; Wang L; Zhang S
    Cell Death Dis; 2024 Mar; 15(3):187. PubMed ID: 38443386
    [TBL] [Abstract] [Full Text] [Related]  

  • 11. Broccoli extracellular vesicles enhance the therapeutic effects and restore the chemosensitivity of 5-fluorouracil on colon cancer.
    Cao Y; Hou L; Li M; Zhang J; Wang L; Liu C; Luo T; Yan L; Zheng L
    Food Chem Toxicol; 2024 Apr; 186():114563. PubMed ID: 38442787
    [TBL] [Abstract] [Full Text] [Related]  

  • 12. CSF1R inhibition reprograms tumor-associated macrophages to potentiate anti-PD-1 therapy efficacy against colorectal cancer.
    Lv Q; Zhang Y; Gao W; Wang J; Hu Y; Yang H; Xie Y; Lv Y; Zhang H; Wu D; Hu L; Wang J
    Pharmacol Res; 2024 Apr; 202():107126. PubMed ID: 38432446
    [TBL] [Abstract] [Full Text] [Related]  

  • 13. Andrographolide sensitizes KRAS-mutant colorectal cancer cells to cetuximab by inhibiting the EGFR/akt and PDGFRβ/akt signaling pathways.
    Liu YF; Feng ZQ; Chu TH; Yi B; Liu J; Yu H; Xue J; Wang YJ; Zhang CZ
    Phytomedicine; 2024 Apr; 126():155462. PubMed ID: 38394734
    [TBL] [Abstract] [Full Text] [Related]  

  • 14. Diallyl disulfide induces DNA damage and growth inhibition in colorectal cancer cells by promoting POU2F1 ubiquitination.
    Xia L; Lin J; Peng M; Jiang X; Peng Q; Cui S; Zhang W; Li S; Wang J; Oyang L; Tan S; Hu Z; Wu N; Tang Y; Luo X; Ren Z; Shi Y; Liao Q; Zhou Y
    Int J Biol Sci; 2024; 20(4):1125-1141. PubMed ID: 38385081
    [TBL] [Abstract] [Full Text] [Related]  

  • 15. A free fatty acid receptor agonist inducing autophagy in HT-29 cells by downregulating the akt/mTOR signaling pathway.
    Hoveizi E; Rafienia B; Shahriari A
    J Cancer Res Ther; 2023 Oct; 19(7):1931-1938. PubMed ID: 38376299
    [TBL] [Abstract] [Full Text] [Related]  

  • 16. Villosol reverses 5-FU resistance in colorectal cancer by inhibiting the CDKN2A gene regulated TP53-PI3K/akt signaling axis.
    Chen H; Deng J; Hou TW; Shan YQ
    J Ethnopharmacol; 2024 May; 325():117907. PubMed ID: 38342156
    [TBL] [Abstract] [Full Text] [Related]  

  • 17. Negative Hyperselection of Resistance Mutations for Panitumumab Maintenance in RAS Wild-Type Metastatic colorectal cancer (PanaMa Phase II Trial, AIO KRK 0212).
    Stahler A; Kind AJ; Sers C; Mamlouk S; Müller L; Karthaus M; Fruehauf S; Graeven U; Fischer von Weikersthal L; Sommerhäuser G; Kasper S; Hoppe B; Kurreck A; Held S; Heinemann V; Horst D; Jarosch A; Stintzing S; Trarbach T; Modest DP
    Clin Cancer Res; 2024 Apr; 30(7):1256-1263. PubMed ID: 38289994
    [TBL] [Abstract] [Full Text] [Related]  

  • 18. In vitro and in vivo anti-colorectal cancer effect of the newly synthesized sericin/propolis/fluorouracil nanoplatform through modulation of PI3K/akt/mTOR pathway.
    Diab SE; Tayea NA; Elwakil BH; Elshewemi SS; Gad AAEM; Abdulmalek SA; Ghareeb DA; Olama ZA
    Sci Rep; 2024 Jan; 14(1):2433. PubMed ID: 38286826
    [TBL] [Abstract] [Full Text] [Related]  

  • 19. The CSF-1R inhibitor pexidartinib affects FLT3-dependent DC differentiation and may antagonize durvalumab effect in patients with advanced cancers.
    Voissière A; Gomez-Roca C; Chabaud S; Rodriguez C; Nkodia A; Berthet J; Montane L; Bidaux AS; Treilleux I; Eberst L; Terret C; Korakis I; Garin G; Pérol D; Delord JP; Caux C; Dubois B; Ménétrier-Caux C; Bendriss-Vermare N; Cassier PA
    Sci Transl Med; 2024 Jan; 16(731):eadd1834. PubMed ID: 38266104
    [TBL] [Abstract] [Full Text] [Related]  

  • 20. Developing a prognosis and chemotherapy evaluating model for colon adenocarcinoma based on mitotic catastrophe-related genes.
    Liu Y; Zhao Y; Zhang S; Rong S; He S; Hua L; Wang X; Chen H
    Sci Rep; 2024 Jan; 14(1):1655. PubMed ID: 38238555
    [TBL] [Abstract] [Full Text] [Related]  


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