Terms: = Colorectal cancer AND CDK12, KIAA0904, CRKRS, 51755, ENSG00000167258, CRK7, CRKR, Q9NYV4
16 results:
1. cdk12 is a potential biomarker for diagnosis, prognosis and immunomodulation in pan-cancer.
Lu KQ; Li ZL; Zhang Q; Yin Q; Zhang YL; Ni WJ; Jiang LZ; He W; Wang B
Sci Rep; 2024 Mar; 14(1):6574. PubMed ID: 38503865
[TBL] [Abstract] [Full Text] [Related]
2. cdk12 inhibition upregulates ATG7 triggering autophagy via AKT/FOXO3 pathway and enhances anti-PD-1 efficacy in colorectal cancer.
Wu Z; Zhang W; Chen L; Wang T; Wang X; Shi H; Zhang L; Zhong M; Shi X; Mao X; Chen H; Li Q
Pharmacol Res; 2024 Mar; 201():107097. PubMed ID: 38354870
[TBL] [Abstract] [Full Text] [Related]
3. NELF and PAF1C complexes are core transcriptional machineries controlling colon cancer stemness.
Aoki K; Nitta A; Igarashi A
Oncogene; 2024 Feb; 43(8):566-577. PubMed ID: 38182897
[TBL] [Abstract] [Full Text] [Related]
4. cdk12 orchestrates super-enhancer-associated CCDC137 transcription to direct hepatic metastasis in colorectal cancer.
Dai W; Wu J; Peng X; Hou W; Huang H; Cheng Q; Liu Z; Luyten W; Schoofs L; Zhou J; Liu S
Clin Transl Med; 2022 Oct; 12(10):e1087. PubMed ID: 36254394
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5. Current progress and novel strategies that target cdk12 for drug discovery.
Lei P; Zhang J; Liao P; Ren C; Wang J; Wang Y
Eur J Med Chem; 2022 Oct; 240():114603. PubMed ID: 35868123
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6. Concurrent BRAFV600E and BRCA Mutations in MSS Metastatic colorectal cancer: Prevalence and Case Series of mCRC patients with prolonged OS.
Cannon TL; Randall JN; Sokol ES; Alexander SM; Wadlow RC; Winer AA; Barnett DM; Rayes DL; Nimeiri HS; McGregor KA
Cancer Treat Res Commun; 2022; 32():100569. PubMed ID: 35567913
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7. An Integrated Proteomics and Bioinformatics Analysis of the Anticancer Properties of RT2 Antimicrobial Peptide on Human Colon cancer (Caco-2) Cells.
Maijaroen S; Klaynongsruang S; Roytrakul S; Konkchaiyaphum M; Taemaitree L; Jangpromma N
Molecules; 2022 Feb; 27(4):. PubMed ID: 35209215
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8. Analysis of cdk12 alterations in a pan-cancer database.
Pan E; Cabal A; Javier-DesLoges J; Patel D; Panian J; Lee S; Shaya J; Nonato T; Xu X; Stewart T; Rose B; Shabaik A; Cohen E; Kurzrock R; Tamayo P; McKay RR
Cancer Med; 2022 Feb; 11(3):753-763. PubMed ID: 34898046
[TBL] [Abstract] [Full Text] [Related]
9. Degradation of CCNK/cdk12 is a druggable vulnerability of colorectal cancer.
Dieter SM; Siegl C; Codó PL; Huerta M; Ostermann-Parucha AL; Schulz E; Zowada MK; Martin S; Laaber K; Nowrouzi A; Blatter M; Kreth S; Westermann F; Benner A; Uhrig U; Putzker K; Lewis J; Haegebarth A; Mumberg D; Holton SJ; Weiske J; Toepper LM; Scheib U; Siemeister G; Ball CR; Kuster B; Stoehr G; Hahne H; Johannes S; Lange M; Herbst F; Glimm H
Cell Rep; 2021 Jul; 36(3):109394. PubMed ID: 34289372
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10. Mutations in DNA Repair Genes and Clinical Outcomes of Patients With Metastatic colorectal cancer Receiving Oxaliplatin or Irinotecan-containing Regimens.
Marks EI; Matera R; Olszewski AJ; Yakirevich E; El-Deiry WS; Safran H; Carneiro BA
Am J Clin Oncol; 2021 Feb; 44(2):68-73. PubMed ID: 33298767
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11. The promise and current status of cdk12/13 inhibition for the treatment of cancer.
Tadesse S; Duckett DR; Monastyrskyi A
Future Med Chem; 2021 Jan; 13(2):117-141. PubMed ID: 33295810
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12. Analysis of DNA Damage Response Gene Alterations and Tumor Mutational Burden Across 17,486 Tubular Gastrointestinal Carcinomas: Implications for Therapy.
Parikh AR; He Y; Hong TS; Corcoran RB; Clark JW; Ryan DP; Zou L; Ting DT; Catenacci DV; Chao J; Fakih M; Klempner SJ; Ross JS; Frampton GM; Miller VA; Ali SM; Schrock AB
Oncologist; 2019 Oct; 24(10):1340-1347. PubMed ID: 31040255
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13. cdk12: an emerging therapeutic target for cancer.
Lui GYL; Grandori C; Kemp CJ
J Clin Pathol; 2018 Nov; 71(11):957-962. PubMed ID: 30104286
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14. Quinalizarin Induces Apoptosis through Reactive Oxygen Species (ROS)-Mediated Mitogen-Activated Protein Kinase (MAPK) and Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathways in colorectal cancer Cells.
Meng LQ; Wang Y; Luo YH; Piao XJ; Liu C; Wang Y; Zhang Y; Wang JR; Wang H; Xu WT; Liu Y; Wu YQ; Sun HN; Han YH; Jin MH; Shen GN; Fang NZ; Jin CH
Med Sci Monit; 2018 Jun; 24():3710-3719. PubMed ID: 29860266
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15. BRCA1 or cdk12 loss sensitizes cells to CHK1 inhibitors.
Paculová H; Kramara J; Šimečková Š; Fedr R; Souček K; Hylse O; Paruch K; Svoboda M; Mistrík M; Kohoutek J
Tumour Biol; 2017 Oct; 39(10):1010428317727479. PubMed ID: 29025359
[TBL] [Abstract] [Full Text] [Related]
16. Effect of RTKN on progression and metastasis of colon cancer in vitro.
Qu GQ; Lu YM; Liu YF; Liu Y; Chen WX; Liao XH; Kong WM
Biomed Pharmacother; 2015 Aug; 74():117-23. PubMed ID: 26349972
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