Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

Terms: = Colorectal cancer AND KEAP1, INrf2, ENSG00000079999, 9817, Q14145, MGC9454, MGC4407, MGC20887, MGC1114, MGC10630, KLHL19, KIAA0132 AND Treatment
20 results:

  • 1. Nuclear Factor Erythroid 2-Related Factor 2/Kelch-Like ECH-Associated Protein 1 as a Predictor of Prognosis and Radiotherapy Resistance in Patients With Locally Advanced Rectal cancer: A Prospective Analysis.
    Park JM; Kim S; Bae SU; Byun SJ; Seo I; Lee HW
    J Korean Med Sci; 2023 Jul; 38(26):e200. PubMed ID: 37401495
    [TBL] [Abstract] [Full Text] [Related]  

  • 2. Mutational analysis of microsatellite-stable gastrointestinal cancer with high tumour mutational burden: a retrospective cohort study.
    Wang J; Xiu J; Farrell A; Baca Y; Arai H; Battaglin F; Kawanishi N; Soni S; Zhang W; Millstein J; Shields AF; Grothey A; Weinberg BA; Marshall JL; Lou E; Khushman M; Sohal DPS; Hall MJ; Liu T; Oberley M; Spetzler D; Korn WM; Shen L; Lenz HJ
    Lancet Oncol; 2023 Feb; 24(2):151-161. PubMed ID: 36681091
    [TBL] [Abstract] [Full Text] [Related]  

  • 3. Gurgem-7 toxicity assessment: Regulation of cell survival or death by traditional Mongolian prescription.
    Batjargal A; Solek P; Kukula-Koch W; Urjin B; Koch W; Koman D; Dudzinska E
    Ecotoxicol Environ Saf; 2022 Jul; 239():113660. PubMed ID: 35605329
    [TBL] [Abstract] [Full Text] [Related]  

  • 4. Improvement of resistance to oxaliplatin by vorinostat in human colorectal cancer cells through inhibition of Nrf2 nuclear translocation.
    Tanaka S; Hosokawa M; Tatsumi A; Asaumi S; Imai R; Ogawara KI
    Biochem Biophys Res Commun; 2022 Jun; 607():9-14. PubMed ID: 35358872
    [TBL] [Abstract] [Full Text] [Related]  

  • 5. EBV infection-induced GPX4 promotes chemoresistance and tumor progression in nasopharyngeal carcinoma.
    Yuan L; Li S; Chen Q; Xia T; Luo D; Li L; Liu S; Guo S; Liu L; Du C; Jia G; Li X; Lu Z; Yang Z; Liu H; Mai H; Tang L
    Cell Death Differ; 2022 Aug; 29(8):1513-1527. PubMed ID: 35105963
    [TBL] [Abstract] [Full Text] [Related]  

  • 6. Auriculasin enhances ROS generation to regulate colorectal cancer cell apoptosis, ferroptosis, oxeiptosis, invasion and colony formation.
    Wang CX; Chen LH; Zhuang HB; Shi ZS; Chen ZC; Pan JP; Hong ZS
    Biochem Biophys Res Commun; 2022 Jan; 587():99-106. PubMed ID: 34872005
    [TBL] [Abstract] [Full Text] [Related]  

  • 7. Activation of anti-oxidant keap1/Nrf2 pathway modulates efficacy of dihydroartemisinin-based monotherapy and combinatory therapy with ionizing radiation.
    Bader S; Wilmers J; Pelzer M; Jendrossek V; Rudner J
    Free Radic Biol Med; 2021 May; 168():44-54. PubMed ID: 33775773
    [TBL] [Abstract] [Full Text] [Related]  

  • 8. The Nrf2 in the pathophysiology of the intestine: Molecular mechanisms and therapeutic implications for inflammatory bowel diseases.
    Piotrowska M; Swierczynski M; Fichna J; Piechota-Polanczyk A
    Pharmacol Res; 2021 Jan; 163():105243. PubMed ID: 33080322
    [TBL] [Abstract] [Full Text] [Related]  

  • 9. FoxO3 reverses 5-fluorouracil resistance in human colorectal cancer cells by inhibiting the Nrf2/TR1 signaling pathway.
    Liu C; Zhao Y; Wang J; Yang Y; Zhang Y; Qu X; Peng S; Yao Z; Zhao S; He B; Mi Q; Zhu Y; Liu X; Zou J; Zhang X; Du Q
    Cancer Lett; 2020 Feb; 470():29-42. PubMed ID: 31811910
    [TBL] [Abstract] [Full Text] [Related]  

  • 10. Epigenetic modifications but not genetic polymorphisms regulate keap1 expression in colorectal cancer.
    Gao L; Yuan F; Che G; Xiao X; Nie X; Wang Y; Jia J; Kong AN; Zhang L
    J Cell Biochem; 2019 Aug; 120(8):12311-12320. PubMed ID: 30825237
    [TBL] [Abstract] [Full Text] [Related]  

  • 11. Traditional Chinese medicine Gegen Qinlian decoction ameliorates irinotecan chemotherapy-induced gut toxicity in mice.
    Wu Y; Wang D; Yang X; Fu C; Zou L; Zhang J
    Biomed Pharmacother; 2019 Jan; 109():2252-2261. PubMed ID: 30551482
    [TBL] [Abstract] [Full Text] [Related]  

  • 12. The role of Nrf2-keap1 axis in colorectal cancer, progression, and chemoresistance.
    Sadeghi MR; Jeddi F; Soozangar N; Somi MH; Samadi N
    Tumour Biol; 2017 Jun; 39(6):1010428317705510. PubMed ID: 28621229
    [TBL] [Abstract] [Full Text] [Related]  

  • 13. Oxidized 5-aminosalicylic acid activates Nrf2-HO-1 pathway by covalently binding to keap1: Implication in anti-inflammatory actions of 5-aminosalicylic acid.
    Kang S; Kim W; Jeong S; Lee Y; Nam J; Lee S; Jung Y
    Free Radic Biol Med; 2017 Jul; 108():715-724. PubMed ID: 28473247
    [TBL] [Abstract] [Full Text] [Related]  

  • 14. An inhibitor of the keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis.
    Lu MC; Ji JA; Jiang YL; Chen ZY; Yuan ZW; You QD; Jiang ZY
    Sci Rep; 2016 May; 6():26585. PubMed ID: 27215610
    [TBL] [Abstract] [Full Text] [Related]  

  • 15. 2-(Pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl) thiophene induces apoptosis through reactive oxygen species-mediated JNK activation in human colon cancer SW620 cells.
    Xu DG; Lv W; Dai CY; Zhu FF; Xu GH; Ma ZJ; Chen Z
    Anat Rec (Hoboken); 2015 Feb; 298(2):376-85. PubMed ID: 25178491
    [TBL] [Abstract] [Full Text] [Related]  

  • 16. Evaluation of ∆2-pioglitazone, an analogue of pioglitazone, on colon cancer cell survival: Evidence of drug treatment association with autophagy and activation of the Nrf2/keap1 pathway.
    Huber S; Valente S; Chaimbault P; Schohn H
    Int J Oncol; 2014 Jul; 45(1):426-38. PubMed ID: 24788124
    [TBL] [Abstract] [Full Text] [Related]  

  • 17. Oxaliplatin activates the keap1/Nrf2 antioxidant system conferring protection against the cytotoxicity of anticancer drugs.
    Wang XJ; Li Y; Luo L; Wang H; Chi Z; Xin A; Li X; Wu J; Tang X
    Free Radic Biol Med; 2014 May; 70():68-77. PubMed ID: 24556415
    [TBL] [Abstract] [Full Text] [Related]  

  • 18. Enhanced 4-hydroxynonenal resistance in keap1 silenced human colon cancer cells.
    Jung KA; Kwak MK
    Oxid Med Cell Longev; 2013; 2013():423965. PubMed ID: 23766854
    [TBL] [Abstract] [Full Text] [Related]  

  • 19. Methylation of the keap1 gene promoter region in human colorectal cancer.
    Hanada N; Takahata T; Zhou Q; Ye X; Sun R; Itoh J; Ishiguro A; Kijima H; Mimura J; Itoh K; Fukuda S; Saijo Y
    BMC Cancer; 2012 Feb; 12():66. PubMed ID: 22325485
    [TBL] [Abstract] [Full Text] [Related]  

  • 20. The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells.
    Wondrak GT; Villeneuve NF; Lamore SD; Bause AS; Jiang T; Zhang DD
    Molecules; 2010 May; 15(5):3338-55. PubMed ID: 20657484
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