Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

Terms: = Colorectal cancer AND MAP2K2, MEK2, 5605, ENSG00000126934, P36507, MKK2, MAPKK2, PRKMK2
23 results:

  • 1. Binimetinib in combination with nivolumab or nivolumab and ipilimumab in patients with previously treated microsatellite-stable metastatic colorectal cancer with RAS mutations in an open-label phase 1b/2 study.
    Elez E; Cubillo A; Alfonso PG; Middleton MR; Chau I; Alkuzweny B; Alcasid A; Zhang X; Van Cutsem E
    BMC Cancer; 2024 Apr; 24(1):446. PubMed ID: 38600471
    [TBL] [Abstract] [Full Text] [Related]  

  • 2. Activation of CHPF by transcription factor NFIC promotes NLRP3 activation during the progression of colorectal cancer.
    Wu J; Wang M; Zhang Y; Liu G; Xing Y
    Funct Integr Genomics; 2024 Jan; 24(1):20. PubMed ID: 38267731
    [TBL] [Abstract] [Full Text] [Related]  

  • 3. Low dose dietary contamination with deoxynivalenol mycotoxin exacerbates enteritis and colorectal cancer in mice.
    Djouina M; Waxin C; Caboche S; Lecointe K; Steimle A; Beury D; Desai MS; Hot D; Dubuquoy L; Launay D; Vignal C; Body-Malapel M
    Sci Total Environ; 2023 Nov; 900():165722. PubMed ID: 37482350
    [TBL] [Abstract] [Full Text] [Related]  

  • 4. Proband-mediated interventions to increase disclosure of genetic risk in families with a BRCA or Lynch syndrome condition: a systematic review.
    Young AL; Imran A; Spoelma MJ; Williams R; Tucker KM; Halliday J; Forrest LE; Wakefield CE; Butow PN
    Eur J Hum Genet; 2023 Jan; 31(1):18-34. PubMed ID: 36253533
    [TBL] [Abstract] [Full Text] [Related]  

  • 5. IGF-1R inhibition induces MEK phosphorylation to promote survival in colon carcinomas.
    Wang Q; Zhang Y; Zhu J; Zheng H; Chen S; Chen L; Yang HS
    Signal Transduct Target Ther; 2020 Aug; 5(1):153. PubMed ID: 32843616
    [TBL] [Abstract] [Full Text] [Related]  

  • 6. Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader.
    Wei J; Hu J; Wang L; Xie L; Jin MS; Chen X; Liu J; Jin J
    J Med Chem; 2019 Dec; 62(23):10897-10911. PubMed ID: 31730343
    [TBL] [Abstract] [Full Text] [Related]  

  • 7. Up-regulation of microRNA-497 inhibits the proliferation, migration and invasion but increases the apoptosis of multiple myeloma cells through the MAPK/ERK signaling pathway by targeting Raf-1.
    Ye CY; Zheng CP; Ying WW; Weng SS
    Cell Cycle; 2018; 17(24):2666-2683. PubMed ID: 30382763
    [TBL] [Abstract] [Full Text] [Related]  

  • 8. Targeting oncogenic Raf protein-serine/threonine kinases in human cancers.
    Roskoski R
    Pharmacol Res; 2018 Sep; 135():239-258. PubMed ID: 30118796
    [TBL] [Abstract] [Full Text] [Related]  

  • 9. Identification of key genes in colorectal cancer using random walk with restart.
    Cui X; Shen K; Xie Z; Liu T; Zhang H
    Mol Med Rep; 2017 Feb; 15(2):867-872. PubMed ID: 28000901
    [TBL] [Abstract] [Full Text] [Related]  

  • 10. Comparison of anti-inflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis.
    Kim H; Banerjee N; Ivanov I; Pfent CM; Prudhomme KR; Bisson WH; Dashwood RH; Talcott ST; Mertens-Talcott SU
    Mol Nutr Food Res; 2016 Sep; 60(9):1912-23. PubMed ID: 27028006
    [TBL] [Abstract] [Full Text] [Related]  

  • 11. Trametinib.
    Zeiser R
    Recent Results Cancer Res; 2014; 201():241-8. PubMed ID: 24756797
    [TBL] [Abstract] [Full Text] [Related]  

  • 12. Small GTPase RBJ mediates nuclear entrapment of MEK1/mek2 in tumor progression.
    Chen T; Yang M; Yu Z; Tang S; Wang C; Zhu X; Guo J; Li N; Zhang W; Hou J; Liu H; Han C; Liu Q; Gu Y; Qian C; Wan T; Cui L; Zhu M; Zheng W; Cao X
    Cancer Cell; 2014 May; 25(5):682-96. PubMed ID: 24746703
    [TBL] [Abstract] [Full Text] [Related]  

  • 13. Trametinib: first global approval.
    Wright CJ; McCormack PL
    Drugs; 2013 Jul; 73(11):1245-54. PubMed ID: 23846731
    [TBL] [Abstract] [Full Text] [Related]  

  • 14. A correction to the research article titled: "Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells" by A. S. Little, K. Balmanno, M. J. Sale, S. Newman, J. R. Dry, M. Hampson, P. A. W. Edwards, P. D. Smith, S. J. Cook.
    Little AS; Balmanno K; Sale MJ; Newman S; Dry JR; Hampson M; Edwards PA; Smith PD; Cook SJ
    Sci Signal; 2011; 4(170):er2. PubMed ID: 21674991
    [TBL] [Abstract] [Full Text] [Related]  

  • 15. miR-143 and miR-145 are downregulated in ulcerative colitis: putative regulators of inflammation and protooncogenes.
    Pekow JR; Dougherty U; Mustafi R; Zhu H; Kocherginsky M; Rubin DT; Hanauer SB; Hart J; Chang EB; Fichera A; Joseph LJ; Bissonnette M
    Inflamm Bowel Dis; 2012 Jan; 18(1):94-100. PubMed ID: 21557394
    [TBL] [Abstract] [Full Text] [Related]  

  • 16. Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells.
    Little AS; Balmanno K; Sale MJ; Newman S; Dry JR; Hampson M; Edwards PA; Smith PD; Cook SJ
    Sci Signal; 2011 Mar; 4(166):ra17. PubMed ID: 21447798
    [TBL] [Abstract] [Full Text] [Related]  

  • 17. Activation of MEK1 or mek2 isoform is sufficient to fully transform intestinal epithelial cells and induce the formation of metastatic tumors.
    Voisin L; Julien C; Duhamel S; Gopalbhai K; Claveau I; Saba-El-Leil MK; Rodrigue-Gervais IG; Gaboury L; Lamarre D; Basik M; Meloche S
    BMC Cancer; 2008 Nov; 8():337. PubMed ID: 19014680
    [TBL] [Abstract] [Full Text] [Related]  

  • 18. Unbiased screening for transcriptional targets of ZKSCAN3 identifies integrin beta 4 and vascular endothelial growth factor as downstream targets.
    Yang L; Zhang L; Wu Q; Boyd DD
    J Biol Chem; 2008 Dec; 283(50):35295-304. PubMed ID: 18940803
    [TBL] [Abstract] [Full Text] [Related]  

  • 19. Major contribution of MEK1 to the activation of ERK1/ERK2 and to the growth of LS174T colon carcinoma cells.
    Shama J; Garcia-Medina R; Pouysségur J; Vial E
    Biochem Biophys Res Commun; 2008 Aug; 372(4):845-9. PubMed ID: 18533112
    [TBL] [Abstract] [Full Text] [Related]  

  • 20. Rapid identification of somatic mutations in colorectal and breast cancer tissues using mismatch repair detection (MRD).
    Bentivegna S; Zheng J; Namsaraev E; Carlton VE; Pavlicek A; Moorhead M; Siddiqui F; Wang Z; Lee L; Ireland JS; Suyenaga K; Willis TD; Faham M; Seymour AB
    Hum Mutat; 2008 Mar; 29(3):441-50. PubMed ID: 18186519
    [TBL] [Abstract] [Full Text] [Related]  


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